Non-starch polysaccharides from Castanea mollissima Bl. ameliorate metabolic syndrome by remodeling barrier function, microbial community, and metabolites in high-fat-diet/streptozotocin-induced diabetic mice
Food Research International,
Год журнала:
2025,
Номер
202, С. 115638 - 115638
Опубликована: Янв. 6, 2025
Язык: Английский
Organ-Specific Effects of Polystyrene Nanoplastics on Deltamethrin-Induced Toxicity in Mice: Mitigated Hepatorenal Oxidative Damage But Increased Enteric Toxicity
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
73(9), С. 5092 - 5101
Опубликована: Фев. 24, 2025
This
study
investigates
the
combined
effects
of
polystyrene
nanoplastics
(PS-NPs)
and
deltamethrin
(DEL)
on
mice,
focusing
their
different
impacts
among
organs.
Mice
were
exposed
to
PS-NPs
and/or
DEL
for
30
days.
Results
showed
that
alleviated
DEL-induced
oxidative
damage
in
liver
kidney
by
reducing
its
accumulation
due
decreased
bioaccessibility.
Conversely,
increased
intestine,
leading
enhanced
susceptibility
enteric
infections
caused
bacteria,
viruses,
parasites,
as
indicated
transcriptomic
analysis.
delayed
excretion
gastrointestinal
motility,
evidenced
altered
neurotransmitter
levels,
thereby
contributing
greater
intestinal
DEL.
Moreover,
16S
rDNA
sequencing
revealed
tended
decrease
beneficial
bacteria
increase
pathogenic
gut
microbiota,
further
heightening
upon
coexposure.
The
findings
this
shed
new
light
complex
health
risks
associated
with
coexposure
pesticides.
Язык: Английский
Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly improve multiple IBD parameters compared to bone marrow MSCs: implications for anti-TNFα-refractory patients
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107716 - 107716
Опубликована: Март 1, 2025
Язык: Английский
Metataxonomics and Metabolomics Profiles in Metabolic Dysfunction-Associated Fatty Liver Disease Patients on a “Navelina” Orange-Enriched Diet
Nutrients,
Год журнала:
2024,
Номер
16(20), С. 3543 - 3543
Опубликована: Окт. 18, 2024
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
is
currently
the
most
common
cause
of
chronic
disease.
Systemic
inflammatory
status
and
peripheral
metabolic
symptoms
in
clinical
picture
have
an
impact
on
gut
commensal
bacteria.
Язык: Английский
Causal relationship between gut microbiota and thyroid nodules: a bidirectional two-sample Mendelian randomization study
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 8, 2024
Objective
Emerging
evidence
suggests
alterations
in
gut
microbiota
(GM)
composition
following
thyroid
nodules
(TNs)
development,
yet
the
causal
relationship
remains
unclear.
Utilizing
Mendelian
Randomization
(MR),
this
study
aims
to
elucidate
dynamics
between
GM
and
TNs.
Methods
Employing
summary
statistics
from
MiBioGen
consortium
(
n
=18,340)
FinnGen
(1,634
TNs
cases,
263,704
controls),
we
conducted
univariable
multivariable
MR
analyses
explore
GM-TNs
association.
Techniques
including
inverse
variance
weighted,
MR-Egger
regression,
weighted
median,
MR-PRESSO
were
utilized
for
inference.
Instrumental
variable
heterogeneity
was
assessed
through
Cochran’s
Q
statistic
leave-one-out
analysis.
Reverse
applied
taxa
showing
significant
forward
associations,
with
multivariate
adjustments
confounders.
Results
Our
findings
suggest
that
certain
microbiota,
identified
as
Ruminococcaceae_NK4A214_group
(OR,
1.89;
95%CI,
0.47-7.64;
p
=
0.040),
Senegalimassilia
1.72;
1.03-2.87;
=0.037),
Lachnospiraceae
(OR,0.64;
95%CI,0.41-0.99;
=0.045),
exhibit
a
protective
influence
against
TNs’
indicated
by
negative
associations.
In
contrast,
categorized
Desulfovibrionales
0.63;
0.41-0.95;
=0.028),
Prevotella_7
0.79;
0.63-1.00;
=0.049),
Faecalibacterium
0.66;
0.44-1.00;
=0.050),
Desulfovibrionaceae
0.55;
0.35-0.86;
=0.008),
Deltaproteobacteria
0.65;
0.43-0.97;
=0.036)
are
have
positive
correlation
TNs,
suggesting
they
may
serve
risk
factors.
did
not
establish
links.
After
comprehensive
adjustment
confounders,
(Order),
(Family),
(Class)
remain
implicated
potential
contributors
risk.
Discussion
This
substantiates
link
underscoring
thyroid-gut
axis’s
relevance.
The
advocate
integration
of
profiles
prevention
management,
offering
foundation
future
research
domain.
Язык: Английский
Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization Study
Biology,
Год журнала:
2024,
Номер
13(9), С. 714 - 714
Опубликована: Сен. 11, 2024
Recent
studies
have
established
associations
between
the
gut
microbiota
(GM)
and
thyroid
diseases
(TDs).
However,
their
causal
relationships
remain
elusive.
Язык: Английский
Bacillus coagulans MF-06 alleviates intestinal mucosal barrier from damage in chicks infected with Salmonella pullorum via activating the Wnt/β-catenin pathway
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 29, 2024
This
study
aimed
to
assess
the
protective
efficacy
of
Язык: Английский