Ferroptosis-Related Gene Signatures: Prognostic Role in HPV-Positive Oropharyngeal Squamous Cell Carcinoma

Cancers, Год журнала: 2025, Номер 17(3), С. 530 - 530

Опубликована: Фев. 5, 2025

Background: Despite advances in the management of head and neck squamous cell carcinoma (HNSCC), prognostic models treatment strategies remain inadequate, particularly for HPV-positive oropharyngeal (OPSCC). The rising incidence OPSCC highlights an urgent need innovative therapeutic approaches. Ferroptosis, a regulated form non-apoptotic death, has gained attention its role cancer progression, but potential as target remains largely unexplored. This study investigates ferroptosis OPSCC, aiming to identify markers provide insights into that could improve patient outcomes. Methods: Thirteen gene expression signatures were retrieved from literature, their performance association immune microenvironment validated on meta-analysis 267 cases (Metanalysis-HPV267) 286 samples BD2Decide project (BD2-HPV286). Results: Our analysis revealed specific ferroptosis-related signatures, FER3, FER4, FER6, FER12, are significantly associated (p-value < 0.05) with high-risk groups adverse tumor features, including suppressed activity enhanced stromal involvement. Elevated CAV1, suppressor, further delineates profiles. Conclusions: These findings highlight significance stratifying patients identifying those poorer clinical Targeting pathways represents novel promising approach addressing unmet effective OPSCC. Future research should focus translating these applications advance precision oncology outcomes this growing population.

Язык: Английский

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COVID-19 and our understanding of vitamin D and immune function

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер 249, С. 106710 - 106710

Опубликована: Фев. 20, 2025

The interaction between vitamin D and the immune system is perhaps most well recognised extraskeletal facet of D, encompassing early studies therapy for TB leprosy through to more recent links with autoimmune disease. However, spotlight on function has been particularly intense in last five years following COVID-19 pandemic. This was due, part, many association status infection disease prognosis, as smaller number clinical trials supplementation. a potential role also stemmed from basic biology that provides plausible mechanistic rationale beneficial effects improved health setting respiratory infection. aim this review summarise different strands evidence supporting effect COVID-19, how modified during pandemic itself, new aspects are likely arise near future. Key topics feature are: antibacterial versus antiviral innate responses 1,25-dihydroxyvitamin (1,25(OH)2D); 1α-hydroxylase (CYP27B1) activity metabolism 25-hydroxyvitamin (25(OH)D) beyond antigen-presenting cells; advances cell target gene (notably changes metabolic profile). Whilst much interest era focused public health, continued evolution our understanding interacts components continues support health.

Язык: Английский

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Autophagy and Programmed Cell Death Modalities Interplay in HIV Pathogenesis

Cells, Год журнала: 2025, Номер 14(5), С. 351 - 351

Опубликована: Фев. 28, 2025

Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according the Joint United Nations Program on HIV/AIDS (UNAIDS) at end of 2021 with 1.5 new infections. New HIV infections increased during 2 years after COVID-19 pandemic. Understanding intricate cellular processes underlying pathogenesis is crucial for developing effective therapeutic strategies. Among these processes, autophagy and programmed cell death modalities, including apoptosis, necroptosis, pyroptosis, ferroptosis, play pivotal roles in host-virus interaction dynamics. Autophagy, highly conserved mechanism, acts as double-edged sword infection, influencing viral replication, immune response modulation, fate infected cells. Conversely, critical defense mechanism against spread contributes depletion CD4+ T cells, hallmark progression. This review aims dissect complex interplay between modalities HIV-induced pathogenesis. It highlights molecular mechanisms involved, their persistence dysfunction, challenges posed by reservoir drug resistance, which continue impede management pathology. Targeting pathways holds promise novel strategies mitigate chronic inflammation, ultimately improving outcomes individuals living HIV.

Язык: Английский

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Activation of nicotinic acetylcholine receptor α7 subunit limits Zika viral infection via promoting autophagy and ferroptosis

Molecular Therapy, Год журнала: 2024, Номер 32(8), С. 2641 - 2661

Опубликована: Май 31, 2024

Язык: Английский

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Magnolol against enterovirus 71 by targeting Nrf2-SLC7A11-GSH pathway

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116866 - 116866

Опубликована: Июнь 14, 2024

Enterovirus 71 (EV71), a prominent pathogen associated with hand, foot, and mouth disease (HFMD), has been reported worldwide. To date, the advancement of effective drugs targeting EV71 remains in preliminary experimental stage. In this study, magnolol demonstrated significant dose-dependent inhibition replication vitro. It upregulated overall expression level nuclear factor erythroid 2 - related (Nrf2) facilitated its nucleus translocation, resulting increased various ferroptosis inhibitory genes. This process led to reduction reactive oxygen species (ROS) accumulation induced by viral infection. Additionally, exhibited broad-spectrum antiviral effect against enteroviruses. Notably, treatment substantially enhanced survival rate EV71-infected mice, attenuated load heart, liver, brain, limb tissues, mitigated tissue inflammation. Taken together, emerges as promising candidate for development anti-EV71 drugs.

Язык: Английский

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Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations

Military Medical Research, Год журнала: 2024, Номер 11(1)

Опубликована: Дек. 16, 2024

Abstract Sepsis, characterized as life-threatening organ dysfunction resulting from dysregulated host responses to infection, remains a significant challenge in clinical practice. Despite advancements understanding host-bacterial interactions, molecular responses, and therapeutic approaches, the mortality rate associated with sepsis has consistently ranged between 10 16%. This elevated highlights critical gaps our comprehension of etiology. Traditionally linked bacterial fungal pathogens, recent outbreaks acute viral infections, including Middle East respiratory syndrome coronavirus (MERS-CoV), influenza virus, severe 2 (SARS-CoV-2), among other regional epidemics, have underscored role pathogenesis sepsis, particularly when critically ill patients exhibit classic symptoms indicative sepsis. However, many cases viral-induced are frequently underdiagnosed because standard evaluations typically exclude panels. Moreover, these viruses not only activate conventional pattern recognition receptors (PRRs) retinoic acid-inducible gene-I (RIG-I)-like (RLRs) but also initiate primary antiviral pathways such cyclic guanosine monophosphate adenosine (GMP-AMP) synthase (cGAS)-stimulator interferon genes (STING) signaling response mechanisms. Such activations lead cellular stress, metabolic disturbances, extensive cell damage that exacerbate tissue injury while leading spectrum manifestations. complexity poses substantial challenges for management affected cases. In this review, we elucidate definition diagnosis criteria synthesizing current knowledge regarding its etiology, epidemiology, pathophysiology, mechanisms involved therein well their impact on immune-mediated damage. Additionally, discuss considerations related both existing therapies advanced treatment interventions, aiming enhance comprehensive surrounding

Язык: Английский

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Peste des petits ruminants virus (PPRV) induces ferroptosis via LONP1-mediated mitochondrial GPX4 degradation in cell culture

Journal of Virology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

ABSTRACT Peste des petits ruminants virus (PPRV) is an important pathogen that seriously affects the productivity of small worldwide. Ferroptosis a programmed cell death characterized by iron-dependent lipid peroxidation and accumulation reactive oxygen species (ROS). Emerging evidence has demonstrated mitochondria play diverse roles in process ferroptosis, but interaction between ferroptosis during infection remains largely unknown. Here, we demonstrate PPRV induces including Fe 2+ overload, peroxidation, shrinkage mitochondria. Importantly, crucial role PPRV-induced decreased mitochondrial GPX4 Mechanistically, downregulates Lon protease-1 (LONP1) expression, multifaceted enzyme essential for maintaining homeostasis function, which leads to degradation through Nrf2/Keap pathway ROS More importantly, tightly associated with inflammatory responses enhanced replication. Overall, this study first show LONP1-mediated involved infection. IMPORTANCE transient severe immunosuppression host, threatens both livestock endangered susceptible wildlife populations many countries. Despite extensive research, it unknown whether causes what mechanism regulation is. Our data provide direct relationship (LONP1)-mediated dysfunctional consequent induction pathogenesis. via mitochondria, replication levels. Taken together, our research provided new insight into understanding effect on pathogenesis revealed potential therapeutic target antiviral intervention.

Язык: Английский

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Scale drop disease virus (SDDV) triggers ferroptosis both in mandarin fish (Siniperca chuatsi) and MFF-1 cells to facilitate virus infection via linking to transferrin receptor 1 (Tfr1)

Fish & Shellfish Immunology, Год журнала: 2025, Номер unknown, С. 110416 - 110416

Опубликована: Май 1, 2025

Язык: Английский

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Roles of programmed cell death in paramyxovirus infection

Journal of Zhejiang University (Medical Sciences), Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Paramyxoviruses are significant respiratory pathogens with substantial clinical relevance in pediatric infectious diseases. During infection, they induce multiple forms of programmed cell death (PCD), which play pivotal roles viral replication, dissemination, and host immune responses, thereby profoundly influencing the life cycle disease progression. On one hand, PCD facilitates clearance infected cells, restricts spread, activates defenses, enhancing antiviral immunity. other excessive or dysregulated may lead to tissue damage imbalance, creating a microenvironment conducive replication exacerbating severity. For instance, apoptosis-mediated by both intrinsic extrinsic pathways-contributes infection control but also be hijacked viruses promote dissemination. Pyroptosis, driven inflammasome activation, triggers lytic release pro-inflammatory cytokines. Necroptosis, mediated RIPK1-RIPK3-MLKL signaling axis, pyroptosis amplify innate responses concurrently inflammatory dysregulation. Immunogenic (ICD), characterized damage-associated molecular patterns (DAMPs) neoantigens, antigen-specific holds therapeutic potential for antitumor interventions. Emerging evidence suggests that ferroptosis, through modulation iron metabolism associated transporters, participate clearance. This review comprehensively summarizes apoptosis, pyroptosis, necroptosis, ICD, ferroptosis paramyxovirus aiming deepen understanding pathogenesis provide insights developing novel strategies, particularly populations.

Язык: Английский

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Hypoxia-inducible factor-1 as targets for neuroprotection : from ferroptosis to Parkinson’s disease

Neurological Sciences, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

Язык: Английский

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