Опубликована: Янв. 1, 2024
Язык: Английский
Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142044 - 142044
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(7), С. 1632 - 1632
Опубликована: Апрель 6, 2025
One pair of novel enantiomers, gigantdioxin A (+)-1 and B (−)-1, with a skeleton benzo[d][1,3]dioxin; new acetophenone gigantone (3); known 3-chlorogentisyl alcohol (2), which is the bioprecursor 1; (4); chromone derivative (5) were obtained from sponge-associated fungus Aspergillus giganteus MA46-5. Their structures established by extensive in-depth spectral analysis, such as UV, 1D 2D NMR, HRESIMS. The absolute configurations (±)-1 deduced ORD, chiral separation, experimental computational ECD. Meanwhile, we proposed possible biosynthetic pathway (±)-1. Fortunately, was proved biomimetic synthesis through 2, bioprecursor, reacted n-butyraldehyde. Myocardial protection assays showed that 3 4 possessed stronger protective effects than positive control against myocardial cell H9c2 ischemia–reperfusion injury in low concentrations, effect (−)-1 almost equal to control. Further, explored mechanism network pharmacology. Adenosine A2a receptor (ADORA2A) serum albumin (ALB) represent potential targets for associated 4, respectively. Based on pharmacology, docked predicted proteins bioactive compounds using Autodock Vina.
Язык: Английский
Процитировано
0
Marine Drugs, Год журнала: 2025, Номер 23(5), С. 197 - 197
Опубликована: Апрель 30, 2025
Marine-derived Penicillium spp., including citrinum, chrysogenum, and sclerotiorum, have emerged as prolific producers of structurally diverse secondary metabolites with cytotoxic activity. This review systematically categorizes 177 bioactive compounds isolated from marine spp. between 2018 2024, derived environments such sediments, animals, plants, mangroves. These compounds, classified into polyketides, alkaloids, terpenoids, steroids, exhibit a wide range activities. Their potency is categorized potent (<1 μM or <0.5 μg/mL), notable (1-10 0.5-5 moderate (10-30 5-15 mild (30-50 15-25 negligible (>50 >25 μg/mL). The current highlights the promising role rich repository for discovery anticancer agents advancement marine-inspired drug development.
Язык: Английский
Процитировано
0
Natural Product Research, Год журнала: 2025, Номер unknown, С. 1 - 6
Опубликована: Май 14, 2025
Certain mangrove endophytic fungi have unique physiological mechanisms, such as anti-inflammatory properties. A new polyketone, namely N-acetoxyethyl-3-(3,5-dimethyl-1,3-heptadienyl)-5-chloro-7-methyl-7-acetoxy-6,8-(2H,7H)-isoquinolinedione (1), and 17 known compounds (2-18) were isolated from the fungus Diaporthe pseudooculi HHUF 30617. The structure of compound was elucidated using nuclear magnetic resonance (NMR) spectroscopy high-resolution electrospray ionisation mass (HRESI-MS). activities evaluated zebrafish migratory fluorescent cell count assay. results suggest potential above for treating inflammation. These findings aid development natural marine products based on fungal metabolites to counter conditions copper toxicity.
Язык: Английский
Процитировано
0
The Microbe, Год журнала: 2025, Номер unknown, С. 100383 - 100383
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Current Research in Biotechnology, Год журнала: 2025, Номер unknown, С. 100300 - 100300
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Marine Drugs, Год журнала: 2025, Номер 23(6), С. 222 - 222
Опубликована: Май 22, 2025
Microalgae offer a sustainable and versatile source of bioactive compounds. Their rapid growth, efficient CO2 utilization, adaptability make them promising alternative to traditional production methods. Key compounds, such as proteins, polyunsaturated fatty acids (PUFAs), polyphenols, phytosterols, pigments, mycosporine-like amino (MAAs), hold significant commercial value are widely utilized in food, nutraceuticals, cosmetics, pharmaceuticals, driving innovation across multiple industries. antiviral enzyme-producing capabilities further enhance industrial medical applications. Additionally, microalgae-based biostimulants plant elicitor peptides (PEPs) contribute agriculture by enhancing growth resilience environmental stressors. The GRAS status several species facilitates market integration, but challenges scaling cost reduction remain. Advances biotechnology metabolic engineering will optimize production, the global microalgae industry. With increasing consumer demand for natural, eco-friendly products, play vital role health, food security, sustainability.
Язык: Английский
Процитировано
0
Journal of Genetic Engineering and Biotechnology, Год журнала: 2025, Номер 23(3), С. 100507 - 100507
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0
Marine Drugs, Год журнала: 2024, Номер 22(9), С. 424 - 424
Опубликована: Сен. 18, 2024
Marine microbial secondary metabolites with diversified structures have been found as promising sources of anti-inflammatory lead compounds. This review summarizes the sources, chemical structures, and pharmacological properties natural products reported from marine microorganisms in past three years (2021–2023). Approximately 252 compounds, including 129 new ones, were predominantly obtained fungi they are structurally divided into polyketides (51.2%), terpenoids (21.0%), alkaloids (18.7%), amides or peptides (4.8%), steroids (4.3%). will shed light on development potential compounds clinical applications human health.
Язык: Английский
Процитировано
1
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Сен. 30, 2024
Thermophilic microorganisms possess several adaptations to thrive in high temperature, which is reflected as biosynthesis of proteins and thermostable molecules, isolation culture represent a great methodological challenge, therefore High throughput sequencing enables screening the whole bacterial genome for functional potential, providing rapid cost-effective information guide targeted cultures identification characterization novel natural products. In this study, we isolated two thermophilic strains corresponding Bacillus LB7 Streptomyces LB8, from microbial mats Atacama Desert. By combining mining, biochemical characterization, aimed identify their capacity synthesize bioactive compounds with antimicrobial properties. Additionally, determined capability produce under controlled vitro assays detected by determining masses Thin-Layer Chromatography/Mass Spectrometry (TLC/MS). Overall, both isolates can (e.g., Myxalamide C by-product) antioxidants (e.g. Dihydroxymandelic Acid, Amide biotine Flavone by-products) compounds. strain possesses more diverse repertoire 51.95% total metabolites unmatched, while LB8 favors mainly antioxidants, but has over 70% unclassified compounds, highlighting necessity study elucidate structure Based on these results, postulate that uncultured or rare cultured thermophiles inhabiting high-altitude hydrothermal ecosystems Desert offer promising opportunity
Язык: Английский
Процитировано
1