Опубликована: Янв. 1, 2024
Язык: Английский
Biomedical & Pharmacology Journal, Год журнала: 2024, Номер 17(4), С. 2341 - 2354
Опубликована: Дек. 30, 2024
Eucheuma cottonii is a type of seaweed that are commonly found in Indonesia. As many other marine organisms, E. builds strong bonding with its endophytic bacteria. These bacteria well known to synthesize various bioactive compounds including antibacterial protect host from bacterial infections and pathogenic Previous study has successfully isolated encoded ISP1RL4 potential against nonresistant Gram-positive Gram-negative target. This research aimed identify the isolate based on DNA sequencing, evaluate activity crude extract multidrug-resistant target analysis chemical profiling extracts. Briefly, cell mass was fermented for 2 weeks 100 mL sterile liquid ISP-2 medium then filtered. Extraction carried out using ethyl acetate an extraction ratio 1:1 twice. Ethyl extracts were tested Methicilin-resistant Staphylococcus aureus (MRSA), Escherichia coli ESBL, Klebsiella pneumoniae Acinetobacter baumanii. Our findings revealed phylogenetically related Pseudomonas aeruginosa strain M4 100% sequence similarity. The P. showed diameter zone inhibition 9.0±1.0 mm, 10.3±2.0 mm 9.4±0.1 MRSA, K. ESBL respectively. No observed A. chromatography-high resolution spectrometry (LC-HRMS) detected 381 2-Amino-1,3,4-octadecanetriol (11.2%) identified as major compound present ISP1RL4. In addition, gas chromatography/mass (GC/MS) 39 11 them have been associated molecules. Among these molecules, four prominent (> 8%) 2-hexanol, 3-hexanol, 3-Pentanol, 2-methyl- 2-hexanone. Overall, ability inhibit selected presence provided promising result could potentially be producer.
Язык: Английский
Процитировано
1
Advances in medical technologies and clinical practice book series, Год журнала: 2024, Номер unknown, С. 117 - 146
Опубликована: Сен. 25, 2024
Cancer is a pathological condition characterized by the uncontrolled growth and dissemination of certain cells inside body. Currently, cancer poses significant global challenge. The marine ecosystem bountiful reservoir biologically potent compounds that carry enormous promise for treatment various ailments, particularly cancer. anticancer properties natural have been previously demonstrated in both laboratory animal investigations. field marine-based pharmaceuticals has begun to an influence on current pharmacology. Various anti-cancer therapies are developed from components officially approved clinical usage. This book chapter specifically examines bioactive obtained habitats properties. It also explores therapeutic applications these molecules wide range innovative sources species purposes.
Язык: Английский
Процитировано
0
Advances in medical technologies and clinical practice book series, Год журнала: 2024, Номер unknown, С. 91 - 116
Опубликована: Сен. 25, 2024
Marine environments are a reservoir of diverse array organisms that generate bioactive compounds with notable anticancer potential. The exploration these marine molecules as potential weapons against cancer cells has gained considerable attention in recent years. These metabolites modulate different biological activities various cancers, including cell proliferation, viability, apoptosis, etc. More than 80% all known species live ecosystems, and many those species' distinctive adaptations allow them to thrive harsh varied habitats. Recently, several from were approved by global regulatory agencies. In this chapter, we have discussed microorganism-derived secondary metabolites, their history, mechanisms action, strategies for the discovery drugs limitations, prospects therapy. Moreover, also demonstrated some which used clinical trials
Язык: Английский
Процитировано
0
Advances in medical technologies and clinical practice book series, Год журнала: 2024, Номер unknown, С. 201 - 234
Опубликована: Авг. 30, 2024
Neurodegenerative diseases like Alzheimer's and Parkinson's pose significant challenges due to their progressive nature limited treatment options. This chapter explores the potential of marine metabolites as therapeutic agents against these debilitating conditions. First, we delve into diverse array organisms known produce compounds with neuroprotective properties. Highlighting specific compounds, such Gracilins, Manzamines, Fucoidan, elucidate mechanisms action, including inhibition key enzymes, reduction neuroinflammation, promotion neurogenesis. Marine Phlorotannins, Bryostatins, Meridianins show promise in mitigating hallmark pathologies tau aggregation beta-amyloid formation. Additionally, discuss marine-derived carotenoids, exemplified by Fucoxanthin, disease management through antioxidant anti-inflammatory effects. offer a rich source novel for neurodegenerative diseases.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0