Antibiotics,
Год журнала:
2024,
Номер
13(5), С. 469 - 469
Опубликована: Май 20, 2024
One
way
that
bacteria
develop
antibiotic
resistance
is
by
reducing
intracellular
concentrations
through
efflux
pumps.
Therefore,
enhancing
the
efficacy
of
antibiotics
using
pump
inhibitors
provides
a
to
overcome
this
type
resistance.
Notably,
an
increasing
number
pathogenic
Staphylococcus
aureus
strains
have
genes.
In
study,
extract
from
Corydalis
ternata
Nakai
tuber
(Corydalis
Tuber)
at
512
mg/L
was
demonstrated
synergistic
effect
with
ciprofloxacin
2
and
tobramycin
1024
against
methicillin-resistant
S.
(MRSA).
Berberine,
isoquinoline
alkaloid
identified
in
Tuber,
as
contributing
effect.
Ethidium
bromide
activity
assays
showed
Tuber
berberine
inhibited
efflux,
suggesting
they
are
inhibitors.
Molecular
docking
simulations
suggested
binds
proteins
MepA,
NorA,
NorB,
SdrM.
Additionally,
inhibit
biofilm
formation,
which
can
confer
This
study’s
findings
suggest
traditional
herbal
medicine,
berberine,
medicinal
supplement,
act
inhibitors,
synergistically
showing
promise
treatment
for
antibiotic-resistant
infections,
including
MRSA.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3529 - 3529
Опубликована: Апрель 9, 2025
Silver
nanoparticles
(AgNPs)
are
used
in
a
variety
of
different
fields
due
to
their
excellent
antimicrobial
potential.
Despite
clear
advantages,
concerns
about
toxicity
have
arisen,
also
concerning
biogenic
nanoparticles.
Simultaneously,
global
healthcare
is
facing
problem
spreading
resistance
towards
existing
antibiotics.
Using
combined
therapies
involving
AgNPs
and
antibiotics
seems
be
promising
solution
the
above
problems.
The
aim
this
study
was
evaluate
enhancement
effectiveness
AgNPs,
ciprofloxacin,
gentamicin
against
Staphylococcus
aureus
Pseudomonas
aeruginosa.
research
involved
assessment
antibiofilm-forming
activities
analysis
phospholipid
fatty
acid
profiles.
Our
results
showed
that
combining
tested
antimicrobials
can
enhance
activity
bacterial
strains.
However,
no
effect
observed
while
mixing
with
ciprofloxacin
P.
most
significant
obtained
by
3.125
µg/mL
0.125
S.
aureus.
It
shown
applied
combination
exhibited
an
increased
inhibitory
biofilm
formation
Lipidomic
revealed
under
influence
antimicrobials,
properties
cell
membrane
were
altered
ways
depending
on
strain.
Frontiers in Veterinary Science,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 30, 2025
Introduction
Staphylococcus
aureus
is
a
zoonotic
pathogen
that
difficult
to
control.
Resveratrol
(RES)
has
been
shown
have
significant
antibacterial
effects.
The
present
study
aimed
investigate
the
inhibitory
effect
of
RES
on
formation
biofilms
and
their
molecular
mechanism.
Methods
First,
minimum
concentration
action
curve
against
were
obtained
through
testing.
Second,
we
found
can
inhibit
biofilm
by
reducing
release
polysaccharide
intercellular
adhesion
(PIA)
extracellular
DNA
(eDNA)
from
.
Results
treatment
significantly
reduced
production
reactive
oxygen
species
(ROS)
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
in
,
indicating
ROS
NADPH
are
closely
related
formation.
Conclusion
This
demonstrates
inhibits
PIA,
eDNA
release,
production,
these
results
provide
new
ideas
for
clinical
application
infection.
