Journal of Biomaterials Applications,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
The
Diels-Alder
reaction,
a
classical
(4+2)
cycloaddition
process,
holds
significant
standing
within
the
realms
of
organic
synthesis
and
polymer
chemistry,
frequently
employed
in
areas
such
as
pharmaceutical
production
material
science.
Recently,
hydrogels
constructed
via
reactions
have
garnered
considerable
attention
from
researchers.
This
review
aims
to
summarize
advancements
utilizing
reaction
for
hydrogel
synthesis,
exploring
its
impact
on
structural
design,
functionalization,
application
domains.
Initially,
fundamental
principles
are
introduced
alongside
an
examination
benefits
characteristics
fabrication.
Subsequently,
applications
Diels-Alder-generated
biomedicine,
smart
responsive
materials,
drug
delivery
systems,
among
other
fields,
comprehensively
reviewed.
Challenges
limitations
encountered
during
using
this
also
discussed.
Finally,
prospective
research
directions
future
prospects
contemplated.
Antibiotics,
Год журнала:
2024,
Номер
13(7), С. 623 - 623
Опубликована: Июль 4, 2024
Hospital-acquired
infections,
also
known
as
nosocomial
include
bloodstream
surgical
site
skin
and
soft
tissue
respiratory
tract
urinary
infections.
According
to
reports,
Gram-positive
Gram-negative
pathogenic
bacteria
account
for
up
70%
of
infections
in
intensive
care
unit
(ICU)
patients.
Biofilm
production
is
a
main
virulence
mechanism
distinguishing
feature
bacterial
pathogens.
Most
pathogens
develop
biofilms
at
the
solid-liquid
air-liquid
interfaces.
An
essential
requirement
biofilm
presence
conditioning
film.
A
film
provides
first
surface
on
which
can
adhere
fosters
growth
by
creating
favorable
environment.
The
improves
microbial
adherence
delivering
chemical
signals
or
generating
microenvironments.
Microorganisms
use
this
coating
nutrient
source.
gathers
both
inorganic
organic
substances
from
its
surroundings,
these
are
generated
microbes
These
nutrients
boost
initial
adhering
facilitate
formation
acting
food
Coatings
with
combined
antibacterial
efficacy
antifouling
properties
provide
further
benefits
preventing
dead
cells
debris
surfaces.
In
present
review,
we
address
numerous
that
form
surfaces
biomedical
devices.
addition,
explore
several
efficient
smart
antiadhesive
coatings
device-relevant
materials
manage
caused
biofilm-forming
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1172 - 1172
Опубликована: Март 6, 2024
Implant-associated
infections
(IAIs)
represent
a
major
health
burden
due
to
the
complex
structural
features
of
biofilms
and
their
inherent
tolerance
antimicrobial
agents
immune
system.
Thus,
viable
options
eradicate
embedded
on
medical
implants
are
surgical
operations
long-term
repeated
antibiotic
courses.
Recent
years
have
witnessed
growing
interest
in
development
robust
reliable
strategies
for
prevention
treatment
IAIs.
In
particular,
it
seems
promising
develop
materials
with
anti-biofouling
antibacterial
properties
combating
IAIs
implants.
this
contribution,
we
exclusively
focus
recent
advances
modified
functionalized
implant
surfaces
inhibiting
bacterial
attachment
eventually
biofilm
formation
orthopedic
Further,
highlight
progress
coatings
(including
self-assembled
nanocoatings)
preventing
Among
recently
introduced
approaches
efficient
durable
coatings,
use
safe
biocompatible
excellent
activities
local
delivery
combinatorial
treating
overcoming
resistance.
Microorganisms,
Год журнала:
2024,
Номер
12(6), С. 1198 - 1198
Опубликована: Июнь 14, 2024
Biofilm
formation
is
a
serious
problem
that
relatively
often
causes
complications
in
orthopedic
surgery.
Biofilm-forming
pathogens
invade
implanted
foreign
bodies
and
surrounding
tissues.
Such
condition,
if
not
limited
at
the
appropriate
time,
requires
reoperation.
This
can
be
partially
prevented
by
selecting
an
prosthesis
material
prevents
development
of
biofilm.
There
are
many
modern
techniques
available
to
detect
formed
By
applying
them
we
identify
visualize
biofilm-forming
microorganisms.
The
most
common
etiological
factors
associated
with
biofilms
orthopedics
are:
Staphylococcus
aureus,
coagulase-negative
Staphylococci
(CoNS),
Enterococcus
spp.,
whereas
Gram-negative
bacilli
Candida
spp.
also
deserve
attention.
It
seems
crucial,
for
therapeutic
success,
eradicate
microorganisms
able
form
biofilm
after
implantation
endoprostheses.
Planning
effective
targeted
antimicrobial
treatment
postoperative
infections
accurate
identification
microorganism
responsible
procedure.
microbiological
testing
described
this
article
show
diagnostic
options
followed
enable
implementation
treatment.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1646 - 1646
Опубликована: Фев. 14, 2025
Implant-associated
infections
are
a
frequent
complication
of
surgeries
involving
biomaterial
implants.
Staphylococcus
and
Enterococcus
species
the
leading
causes
linked
to
bone-anchored
joint
To
address
this
challenge,
developing
antibacterial
coatings
prevent
bacterial
attachment
biofilm
formation
on
biomaterials
is
critical.
This
study
aimed
evaluate
antibiofilm
properties
two
coatings:
titanium
nitride
(TiN)
with
silver
nanoparticles
(TiN/Ag).
Antibacterial
activity
was
tested
against
common
biofilm-forming
pathogens,
including
Escherichia
coli,
aureus,
faecalis,
faecium.
The
results
demonstrated
that
both
significantly
reduced
cell
counts,
TiN/Ag
coating
showing
superior
performance
due
addition
nanoparticles.
enhancement
particularly
effective
in
reducing
across
all
strains,
most
pronounced
effects
observed
for
E.
faecium
faecalis.
synergistically
improved
TiN
coating,
efficiently
disrupting
integrity
adhesion.
By
surfaces,
offer
promising
strategy
minimize
complications
associated
These
findings
highlight
potential
medical
applications.
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
The
current
antibacterial
strategies
focus
on
antibiotic
therapy
and
extensive
hygienic
measures
during
orthopedic
surgery.
However,
potential
development
of
implant-associated
infections
remains
a
persistent
clinical
challenge.
There
is,
therefore,
growing
interest
in
introducing
innovative
safe
for
preventing
combating
biofilm
implants.
Antibacterial
coatings,
particularly,
are
attractive
local
delivery
agents.
We
aim
this
proof-of-concept
study
at
novel
translatable
implant
coating
approach,
focusing
directed
assembly
inverse
non-lamellar
lyotropic
liquid
crystalline
(LLC)
nanostructures
implants
prevention
initial
bacterial
attachment
formation
through
the
widely
used
cationic
colistin
(COL).
On
exposure
dry
lipid
films
deposited
model
to
aqueous
solutions
COL
prepared
different
concentrations,
set
LLC
coatings
based
commercial
distilled
monoglyceride
product
(or
glycerol
monooleate)
were
produced.
In
addition
small-angle
X-ray
scattering
(SAXS)
characterization
investigations,
vitro
studies
conducted
evaluating
antibiofilm
properties
against
Gram-negative
bacteria
Pseudomonas
aeruginosa.
SAXS
analysis
indicated
that
all
samples
bicontinuous
cubic
Pn3m
phases.
Significant
COL's
activity
efficient
protection
adhesion
demonstrated
with
surface
produced
by
using
containing
concentrations
50
500
µg/mL.
serum,
detected
structural
alterations
changes
also
discussed.
This
highlights
implications
self-assemblies
designing
nanostructural
implants,
which
can
prevent
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
Infected
bone
defects,
caused
by
bacterial
contamination
following
disease
or
injury,
result
in
the
partial
loss
destruction
of
tissue.
Traditional
transplantation
and
other
clinical
approaches
often
fail
to
address
therapeutic
complexities
these
conditions
effectively.
In
recent
years,
advanced
biomaterials
have
attracted
significant
attention
for
their
potential
enhance
treatment
outcomes.
This
review
explores
pathogenic
mechanisms
underlying
infected
including
biofilm
formation
internalization
into
cells,
which
allow
bacteria
evade
host
immune
system.
To
control
infection
facilitate
repair,
we
focus
on
antibacterial
materials
regeneration.
A
detailed
introduction
is
given
intrinsically
(e.g.,
metal
alloys,
oxide
materials,
carbon-based
hydroxyapatite,
chitosan,
Sericin).
The
functionality
repair
can
be
enhanced
through
strategies
such
as
incorporation
antimicrobial
ions,
surface
modification,
combined
use
multiple
treat
defects.
Key
innovations
discussed
include
that
release
agents,
functional
contact
biomaterials,
bioresponsive
collectively
efficacy.
Research
translation
has
also
facilitated
practical
application
prevention
healing.
conclusion,
advancements
provide
promising
pathways
developing
more
biocompatible,
effective,
personalized
therapies
reconstruct
MedComm – Biomaterials and Applications,
Год журнала:
2024,
Номер
3(3)
Опубликована: Сен. 1, 2024
Abstract
The
rapid
evolution
of
clinical
medicine,
materials
science,
and
regenerative
medicine
has
rendered
traditional
implantable
scaffolds
inadequate
for
addressing
the
complex
therapeutic
demands
various
diseases.
Currently,
in
practice
are
mainly
made
metal,
with
disadvantages
high
stiffness,
poor
toughness,
low
deformation.
This
paper
offers
a
thorough
review
shape
memory
(SMSs),
emphasizing
their
distinctive
self‐recovery
adaptive
functionalities
that
enhance
compatibility
injured
tissues,
surpassing
capabilities
conventional
metallic
biomaterials.
It
delves
into
limitations
current
requisite
performance
metrics
effective
implants
outlines
essential
fabrication
methods
SMSs.
Moreover,
we
enumerate
biomedical
applications
SMMs
different
response
types,
including
thermology‐responsive,
water‐responsive,
light‐responsive.
discussion
extends
to
burgeoning
SMSs
engineering,
utility
bone
tissue
cardiovascular
stenting,
tubular
structures,
cardiac
patches,
which
underscore
potential
minimally
invasive
procedures
dynamic
interactions.
concludes
an
analysis
challenges
prospects,
providing
valuable
insights
developing
applying
sector.
