Gut Microbiota’s role in lipoma development: evidence from mendelian randomization DOI Creative Commons
Yuxin Li, Jiahao Chen, Hang Yao

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Ноя. 15, 2024

Background Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients’ physical and psychological wellbeing. Increasing evidence points to strong link between the gut microbiome (GM) lipoma incidence. This study utilizes Mendelian Randomization (MR) assess potential causal relationships GM development. Methods We conducted two-sample MR analysis using genome-wide association (GWAS) data MiBioGen FinnGen explore relationship lipoma. The dataset included 18,340 participants with 14,587 single nucleotide polymorphisms (SNPs), while comprised 412,181 21,306,349 SNPs. employed 5 methods: Inverse Variance Weighted (IVW), Median, Simple Mode, MR-Egger, Mode. Additional assessments Cochran’s Q test for result heterogeneity, PRESSO horizontal pleiotropy, sensitivity analyses through scatter plots, leave-one-out analyses, funnel forest plots. Results IVW method identified 18 gene predictors trans-genus associated risk. Protective effects against (BL) were observed in Eubacterium rectale group, Desulfovibrio, Ruminococcus1, Clostridium sensu stricto1, Lachnospiraceae UCG001; conversely, UCG008 was linked increased BL Desulfovibrio provided protection TS-BL; however, Family XIII AD3011 coprostanoligenes NK4A136 Parasutterella an TS-BL innocuum Anaerotruncus, Ruminiclostridium6, UCG001 offered LS-BL, LS-BL brachy Odoribacter, Butyricimonas, Subdoligranulum, stricto1 protective HFNS-BL; Ruminococcaceae UCG005 HFNS-BL Conclusion Compared malignant tumors, research on lipomas has been relatively limited. study, analysis, new of specific development lipomas. Certain bacterial species may act as or harmful factors formation, offering avenues future treatment strategies. However, additional is required unravel complexity how influences pathogenesis

Язык: Английский

Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Jiahao Chen,

Yu Wang,

Hang Yao

и другие.

Biology, Год журнала: 2024, Номер 13(9), С. 714 - 714

Опубликована: Сен. 11, 2024

Recent studies have established associations between the gut microbiota (GM) and thyroid diseases (TDs). However, their causal relationships remain elusive.

Язык: Английский

Процитировано

0
Gut Microbiota’s role in lipoma development: evidence from mendelian randomization DOI Creative Commons
Yuxin Li, Jiahao Chen, Hang Yao

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Ноя. 15, 2024

Background Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients’ physical and psychological wellbeing. Increasing evidence points to strong link between the gut microbiome (GM) lipoma incidence. This study utilizes Mendelian Randomization (MR) assess potential causal relationships GM development. Methods We conducted two-sample MR analysis using genome-wide association (GWAS) data MiBioGen FinnGen explore relationship lipoma. The dataset included 18,340 participants with 14,587 single nucleotide polymorphisms (SNPs), while comprised 412,181 21,306,349 SNPs. employed 5 methods: Inverse Variance Weighted (IVW), Median, Simple Mode, MR-Egger, Mode. Additional assessments Cochran’s Q test for result heterogeneity, PRESSO horizontal pleiotropy, sensitivity analyses through scatter plots, leave-one-out analyses, funnel forest plots. Results IVW method identified 18 gene predictors trans-genus associated risk. Protective effects against (BL) were observed in Eubacterium rectale group, Desulfovibrio, Ruminococcus1, Clostridium sensu stricto1, Lachnospiraceae UCG001; conversely, UCG008 was linked increased BL Desulfovibrio provided protection TS-BL; however, Family XIII AD3011 coprostanoligenes NK4A136 Parasutterella an TS-BL innocuum Anaerotruncus, Ruminiclostridium6, UCG001 offered LS-BL, LS-BL brachy Odoribacter, Butyricimonas, Subdoligranulum, stricto1 protective HFNS-BL; Ruminococcaceae UCG005 HFNS-BL Conclusion Compared malignant tumors, research on lipomas has been relatively limited. study, analysis, new of specific development lipomas. Certain bacterial species may act as or harmful factors formation, offering avenues future treatment strategies. However, additional is required unravel complexity how influences pathogenesis

Язык: Английский

Процитировано

0