Targeting the Gut Microbiota for Prevention and Management of Type 2 Diabetes
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3951 - 3951
Опубликована: Ноя. 19, 2024
Type
2
diabetes
(T2D)
is
a
chronic
metabolic
disorder
with
heterogeneous
etiology
encompassing
societal
and
behavioral
risk
factors
in
addition
to
genetic
environmental
susceptibility.
The
cardiovascular
consequences
of
account
for
more
than
two-thirds
mortality
among
people
T2D.
Not
only
does
T2D
shorten
life
expectancy,
but
it
also
lowers
quality
associated
extremely
high
health
expenditures
since
diabetic
complications
raise
both
direct
indirect
healthcare
costs.
An
increasing
body
research
indicates
connection
between
gut
microbial
traits,
as
numerous
alterations
the
intestinal
microorganisms
have
been
noted
pre-diabetic
individuals.
These
include
pro-inflammatory
bacterial
patterns,
increased
permeability,
endotoxemia,
hyperglycemia-favoring
conditions,
such
alteration
glucagon-like
peptide-1
(GLP-1)
secretion.
Restoring
homeostasis
can
be
very
beneficial
preventing
co-treating
improving
antidiabetic
therapy
outcomes.
This
review
summarizes
characteristics
"diabetic"
microbiota
metabolites
produced
by
species
that
worsen
or
ameliorate
progression,
suggesting
microbiota-targeted
strategies
restore
eubiosis
regulate
blood
glucose.
Nutritional
supplementation,
diet,
physical
exercise
are
known
play
important
roles
T2D,
here
their
effects
on
discussed,
non-pharmacological
approaches
greatly
help
management
highlighting
importance
tailoring
treatments
individual
needs.
Язык: Английский
Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies
Cells,
Год журнала:
2025,
Номер
14(2), С. 84 - 84
Опубликована: Янв. 9, 2025
Hepatocellular
carcinoma
(HCC)
is
a
heterogeneous
tumor
associated
with
several
risk
factors,
non-alcoholic
fatty
liver
disease
(NAFLD)
emerging
as
an
important
cause
of
tumorigenesis.
Due
to
the
obesity
epidemics,
occurrence
NAFLD
has
significantly
increased
nearly
30%
prevalence
worldwide.
HCC
often
arises
in
background
chronic
(CLD),
such
nonalcoholic
steatohepatitis
(NASH)
and
cirrhosis.
Gut
microbiome
(GM)
alterations
have
been
linked
progression
development,
investigations
reporting
crucial
role
for
gut-liver
axis
microbial
metabolites
promoting
CLD.
Moreover,
GM
affects
homeostasis,
energy
status,
immune
microenvironment,
influencing
response
immunotherapy
interesting
therapeutic
implications.
In
this
review,
we
summarize
main
changes
derived
(e.g.,
short-chain
acids
bile
acids)
occurring
patients
progression,
emphasizing
their
potential
early
diagnostic
biomarkers
prognostic
tools.
We
discuss
weight
loss
effects
diet-based
interventions
healthy
lifestyles
treatment
patients,
highlighting
impact
on
restoration
intestinal
barrier
structure.
also
describe
encouraging
preclinical
findings
modulation
improve
functions
CLD,
boost
antitumor
probiotic
supplementations
or
anti-hypercholesterolemic
drug
treatment),
ultimately
delay
HCC.
The
development
safe
effective
strategies
that
target
holds
promise
cancer
prevention
treatment,
especially
if
personalized
options
will
be
considered.
Язык: Английский
Research Progress of Non-Alcoholic Fatty Liver Disease from the Perspective of Intestinal Flora
Advances in Clinical Medicine,
Год журнала:
2025,
Номер
15(03), С. 477 - 490
Опубликована: Янв. 1, 2025
Язык: Английский
Effect of Oral Microbiota Composition on Metabolic Dysfunction-Associated Steatotic Liver Disease in the General Population
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2013 - 2013
Опубликована: Март 16, 2025
Background/Objective:
This
study
investigated
the
relationship
between
composition
of
oral
microbiota
and
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
in
general
population.
Methods:
In
total,
712
participants
a
health
check-up
project
were
divided
into
four
patterns
by
principal
component
analysis
cluster
analysis;
they
included
Neisseria,
Streptococcus,
Fusobacterium,
Veillonella
groups.
The
Neisseria
group
had
largest
number
patients
was
used
as
reference
to
compare
incidence
MASLD
cardiometabolic
criteria
with
other
Results:
multivariate
analysis,
risk
factor
for
independent
compared
group.
correlation
bacterial
species
MASLD-related
items
showed
that
negatively
correlated
controlled
attenuation
parameters,
body
mass
index,
waist
circumference,
hemoglobin
A1c,
alanine
aminotransferase,
fatty
index.
positive
blood
pressure,
triglycerides,
aspartate
gamma-glutamyl
transpeptidase,
negative
high-density
lipoprotein
cholesterol.
contrast,
Streptococcus
Fusobacterium
groups
not
clearly
associated
MASLD.
Conclusions:
Maintaining
hygiene
preventing
periodontitis
may
contribute
extending
healthy
lifespan.
Язык: Английский
Impact of gut microbiota on metabolic dysfunction-associated steatohepatitis and hepatocellular carcinoma: pathways, diagnostic opportunities and therapeutic advances
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Окт. 5, 2024
Язык: Английский
Associations of dietary sources of antioxidant intake and NAFLD: NHANES 2017–2020 and Mendelian randomization
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 30, 2024
To
determine
the
association
between
dietary
antioxidant
sources
and
non-alcoholic
fatty
liver
disease
(NAFLD).
Язык: Английский