Mycosynthesis of zinc oxide nanoparticles using Mucor racemosus with their antimicrobial, antibiofilm, anticancer and antioxidant activities DOI Creative Commons
Fathy M. Elkady, Bahaa Mohammed Badr, Ebrahim Saied

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 28, 2025

The unregulated administration of currently available antimicrobial agents resulted in overspreading resistant microbial phenotypes. In this study, Mucor racemosus was used for biosynthesis zinc oxide nanoparticles (ZnO NPs) through fungi-based ecofriendly approach. biosynthesized ZnO NPs initially considered based on analytical practices including UV-vis spectroscopy and transmission electron microscopy (TEM). Additionally, their cytotoxicity anticancer activity were analyzed using suitable cell lines antioxidant effect also assessed. Microbiologically, inhibitory comparatively evaluated against various methicillinresistant Staphylococcus aureus (MRSA) methicillinsensitive (MSSA). Characterization displayed a distinct maximum absorption peak at 320 nm appeared the UV-vis. Also, TEM revealed predominantly spherical with particle size distribution ranging from 15 to 55 (mean ≃ 40 nm). normal line (Wi-38) illustrated biosafety NPs, where results showed IC50 197.2 µg/mL. Furthermore, exhibited promising suppressive Hep-G2 cancerous 51.4 Besides, 69.2 As well, minimum concentrations tested MRSA MSSA isolates ranged 32 512 bactericidal lower range, 32-1024 µg/mL, than recorded 128-1024 MSSA. crystal violet (CV) assay an eradication potential biofilm range 23.24-73.96% 6.63-74.1%, respectively. conclusion, synthesized activities demonstrated planktonic growth form clinical capability eradicate preformed biofilm. To achieve full potential, future research needs enhance synthesis process make more uniform scalable, as well investigate action mechanisms molecular level.

Язык: Английский

Novel Erodium glaucophyllum (L.) Aiton growing in arid environment: Phytochemical characterization, antimicrobial, antioxidant, and anticancer potential DOI Creative Commons
Amr H. Hashem, Bahaa Mohammed Badr, Fathy M. Elkady

и другие.

Electronic Journal of Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Schefflera eliptica Leaf Extract as Antibiofilm Agent Against the Clinical Isolates of Staphylococcus aureus in Wound, Blood, and Sputum DOI Open Access
Marta Setiabudy, Anak Agung Gede Indraningrat,

Kadek Suryawan

и другие.

Biomedical & Pharmacology Journal, Год журнала: 2025, Номер 18(1), С. 813 - 822

Опубликована: Март 31, 2025

Schefflera elliptica leaves contain secondary metabolites such as flavonoids, tannins, and saponins that have the potential antibiofilm agents. Biofilms produced by Staphylococcus aureus are often cause of chronic infections, especially on wounds medical devices catheters. Antibiofilm activity plant extracts is promising an adjuvant or alternative therapy. The purpose this study was to determine ethyl acetate extract S. leaf against clinical isolates aureus. This analytical with a laboratory experimental design activity. research samples were 18 obtained from patients undergoing examination at hospital June 2022 December 2022. carried out using stages sample preparation, biofilm assay microtiter plate, antimicrobial test disc diffusion method. results showed able reduce average formation significantly (p<0.001), both doses 10 µL (reduced 12%) 20 56.7%). Despite having activity, dose ul no minimal Overall, indicate has agent expected be basis further for development natural materials.

Язык: Английский

Процитировано

0
Mycosynthesis of zinc oxide nanoparticles using Mucor racemosus with their antimicrobial, antibiofilm, anticancer and antioxidant activities DOI Creative Commons
Fathy M. Elkady, Bahaa Mohammed Badr, Ebrahim Saied

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 28, 2025

The unregulated administration of currently available antimicrobial agents resulted in overspreading resistant microbial phenotypes. In this study, Mucor racemosus was used for biosynthesis zinc oxide nanoparticles (ZnO NPs) through fungi-based ecofriendly approach. biosynthesized ZnO NPs initially considered based on analytical practices including UV-vis spectroscopy and transmission electron microscopy (TEM). Additionally, their cytotoxicity anticancer activity were analyzed using suitable cell lines antioxidant effect also assessed. Microbiologically, inhibitory comparatively evaluated against various methicillinresistant Staphylococcus aureus (MRSA) methicillinsensitive (MSSA). Characterization displayed a distinct maximum absorption peak at 320 nm appeared the UV-vis. Also, TEM revealed predominantly spherical with particle size distribution ranging from 15 to 55 (mean ≃ 40 nm). normal line (Wi-38) illustrated biosafety NPs, where results showed IC50 197.2 µg/mL. Furthermore, exhibited promising suppressive Hep-G2 cancerous 51.4 Besides, 69.2 As well, minimum concentrations tested MRSA MSSA isolates ranged 32 512 bactericidal lower range, 32-1024 µg/mL, than recorded 128-1024 MSSA. crystal violet (CV) assay an eradication potential biofilm range 23.24-73.96% 6.63-74.1%, respectively. conclusion, synthesized activities demonstrated planktonic growth form clinical capability eradicate preformed biofilm. To achieve full potential, future research needs enhance synthesis process make more uniform scalable, as well investigate action mechanisms molecular level.

Язык: Английский

Процитировано

0