Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder DOI Creative Commons

Feiyun Huang,

Nan Yang, Qingqing Zhang

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1181 - 1181

Опубликована: Март 28, 2025

Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health suppress pathogens. We introduced a novel edible probiotic, Enterococcus faecalis HY0110, isolated from marine Thunnus thynnus. Through comprehensive in vitro, vivo, metabolomic analyses, we demonstrated its superior antibacterial effects compared Lactobacillus rhamnosus GG, along with significantly enhanced antioxidant free-radical scavenging capacities. Notably, elevated acetic acid production strongly correlated efficacy (R ≥ 0.999). HY0110 also exerted antiproliferative on HT-29 colorectal cancer cells by attenuating β-catenin BCL-2 expression while upregulating pro-apoptotic markers P62 c-PARP. In DSS-induced colitis model, alleviated inflammation, restored microbial homeostasis, deterministic processes community assembly dynamics. Furthermore, fermenting Periplaneta americana powder triggered extensive metabolic remodeling, notably 668.73-fold rise astragaloside A, plus increases L-Leucyl-L-Alanine, S-lactoylglutathione, 16,16-dimethyl prostaglandin A1. These shifts diminished harmful components amplified essential amino acids peptides bolster immune modulation, redox balance, anti-inflammatory responses. This work established transformative paradigm for utilizing probiotics entomological substrates functional foods, presenting strategic pathways precision nutrition management.

Язык: Английский

Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder DOI Creative Commons

Feiyun Huang,

Nan Yang, Qingqing Zhang

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1181 - 1181

Опубликована: Март 28, 2025

Addressing the escalating global burdens of inflammatory bowel disease and antimicrobial resistance demanded innovative food-based approaches to fortify gut health suppress pathogens. We introduced a novel edible probiotic, Enterococcus faecalis HY0110, isolated from marine Thunnus thynnus. Through comprehensive in vitro, vivo, metabolomic analyses, we demonstrated its superior antibacterial effects compared Lactobacillus rhamnosus GG, along with significantly enhanced antioxidant free-radical scavenging capacities. Notably, elevated acetic acid production strongly correlated efficacy (R ≥ 0.999). HY0110 also exerted antiproliferative on HT-29 colorectal cancer cells by attenuating β-catenin BCL-2 expression while upregulating pro-apoptotic markers P62 c-PARP. In DSS-induced colitis model, alleviated inflammation, restored microbial homeostasis, deterministic processes community assembly dynamics. Furthermore, fermenting Periplaneta americana powder triggered extensive metabolic remodeling, notably 668.73-fold rise astragaloside A, plus increases L-Leucyl-L-Alanine, S-lactoylglutathione, 16,16-dimethyl prostaglandin A1. These shifts diminished harmful components amplified essential amino acids peptides bolster immune modulation, redox balance, anti-inflammatory responses. This work established transformative paradigm for utilizing probiotics entomological substrates functional foods, presenting strategic pathways precision nutrition management.

Язык: Английский

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