Biomedical Journal, Год журнала: 2025, Номер unknown, С. 100867 - 100867

Опубликована: Апрель 1, 2025

Cardiac macrophages (CMs) are the most abundant immune cell type in heart. They critical for maintaining cardiac homeostasis and orchestration of responses to ischemic non-ischemic cardiomyopathies. Their functions highly heterogeneous regulated by their tissue microenvironment. CMs have high plasticity, which allows them perform various myocardium bring about within cardiovascular system (CVS). also play roles coronary development angiogenesis, repair remodeling, conduction clearance necrotic apoptotic cells. However, there is a paucity studies on biology both steady state disease, especially, humans. In this review, we discuss multifaceted heart, focusing ontogeny, homeostatic immunological during inflammation reparative processes post-injury. We highlight heterogeneity phenotypes as well pathogenesis pathological conditions such myocarditis, myocardial fibrosis heart failure. Understanding unique characteristics milieu macrophage-specific therapeutic interventions alleviate global burden disease (CVD). Therefore, future should focus further improving understanding harness potential targets disorders.

Язык: Английский