The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 859 - 859
Опубликована: Фев. 28, 2025
Ultra-processed
foods
(UPFs)
have
become
a
widely
consumed
food
category
in
modern
diets.
However,
their
impact
on
gut
health
is
raising
increasing
concerns.
This
review
investigates
how
UPFs
the
microbiome
and
barrier,
emphasizing
dysbiosis
increased
permeability.
UPFs,
characterized
by
high
content
of
synthetic
additives
emulsifiers,
low
fiber
content,
are
associated
with
decrease
microbial
diversity,
lower
levels
beneficial
bacteria
like
Akkermansia
muciniphila
Faecalibacterium
prausnitzii,
an
increase
pro-inflammatory
microorganisms.
These
alterations
community
contribute
to
persistent
inflammation,
which
various
chronic
disorders
including
metabolic
syndrome,
irritable
bowel
type
2
diabetes,
colorectal
cancer.
In
addition,
may
alter
gut-brain
axis,
potentially
affecting
cognitive
function
mental
health.
Dietary
modifications
incorporating
fiber,
fermented
foods,
probiotics
can
help
mitigate
effects
UPFs.
Furthermore,
public
needs
stricter
regulations
for
banning
along
well-defined
labels.
Further
studies
necessary
elucidate
mechanisms
connecting
systemic
illnesses,
thereby
informing
evidence-based
dietary
guidelines.
Язык: Английский
Impact of gender and reproductive states on diets and intestinal microbiota in Pratt's leaf-nosed bats (Hipposideros pratti)
Comparative Biochemistry and Physiology Part D Genomics and Proteomics,
Год журнала:
2025,
Номер
54, С. 101459 - 101459
Опубликована: Фев. 27, 2025
Язык: Английский
The Oral–Gut Microbiome–Brain Axis in Cognition
Noorul Ain Adil,
Christabel Omo-Erigbe,
Hariom Yadav
и другие.
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 814 - 814
Опубликована: Апрель 3, 2025
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
cognitive
decline
and
neuronal
loss,
affecting
millions
worldwide.
Emerging
evidence
highlights
the
oral
microbiome—a
complex
ecosystem
of
bacteria,
fungi,
viruses,
protozoa
as
significant
factor
in
health.
Dysbiosis
microbiome
contributes
to
systemic
inflammation,
disrupts
blood–brain
barrier,
promotes
neuroinflammation,
processes
increasingly
implicated
pathogenesis
AD.
This
review
examines
mechanisms
linking
dysbiosis
through
oral–brain
oral–gut–brain
axis.
These
interconnected
pathways
enable
bidirectional
communication
between
cavity,
gut,
brain
via
neural,
immune,
endocrine
signaling.
Oral
pathogens,
such
Porphyromonas
gingivalis,
along
with
virulence
factors,
including
lipopolysaccharides
(LPS)
gingipains,
contribute
while
metabolic
byproducts,
short-chain
fatty
acids
(SCFAs)
peptidoglycans,
further
exacerbate
immune
activation.
Additionally,
this
explores
influence
external
diet,
pH
balance,
medication
use,
smoking,
alcohol
consumption,
hygiene,
on
microbial
diversity
stability,
highlighting
their
role
shaping
outcomes.
The
dynamic
interplay
gut
microbiomes
reinforces
importance
homeostasis
preserving
neurological
interventions,
probiotics,
prebiotics,
dietary
modifications,
offer
promising
strategies
support
function
reduce
risk
diseases,
AD,
maintaining
diverse
microbiome.
Future
longitudinal
research
needed
identify
long-term
impact
cognition.
Язык: Английский
Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies
Pharmacological Research,
Год журнала:
2025,
Номер
215, С. 107726 - 107726
Опубликована: Апрель 4, 2025
Triple-negative
breast
cancer
(TNBC)
is
an
aggressive
subtype
of
with
limited
treatment
options
and
poor
prognosis.
The
gut
microbiota,
a
diverse
community
microorganisms
in
the
gastrointestinal
tract,
plays
crucial
role
regulating
immune
responses
through
gut-immune
axis.
Recent
studies
have
highlighted
its
significant
impact
on
TNBC
progression
efficacy
immunotherapies.
This
review
examines
interactions
between
microbiota
system
TNBC,
focusing
key
cells
pathways
involved
tumor
immunity.
It
also
explores
modulation
strategies,
including
probiotics,
prebiotics,
dietary
interventions,
fecal
transplantation,
as
potential
methods
to
enhance
immunotherapeutic
outcomes.
Understanding
these
mechanisms
offers
promising
avenues
for
improving
patient
prognosis
TNBC.
Язык: Английский
Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 963 - 963
Опубликована: Апрель 15, 2025
Background/Objectives:
This
review
has
been
prepared
to
promote
interest
in
the
interdisciplinary
study
of
mitochondrial
dysfunction
(MD)
and
atherosclerosis.
aims
describe
state
this
problem
indicate
direction
for
further
implementation
knowledge
clinical
medicine.
Methods:
Extensive
research
literature
was
implemented
elucidate
role
molecular
mechanisms
MD
pathogenesis
Results:
A
view
on
atherosclerosis
through
prism
about
is
presented.
cause
primary
mechanism
onset
progression
It
proposed
that
be
considered
context
a
continuum.
Conclusions:
are
united
by
common
pathogenesis.
Knowledge
should
used
argue
healthy
lifestyle
as
way
prevent
The
development
new
approaches
diagnosing
treating
an
urgent
task
challenge
modern
science.
Язык: Английский