Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101384 - 101384
Опубликована: Окт. 1, 2024
Язык: Английский
Coatings, Год журнала: 2023, Номер 13(10), С. 1772 - 1772
Опубликована: Окт. 15, 2023
In recent years, significant progress has been made in the surface functionalization of magnetic nanoparticles (MNPs), revolutionizing their utility multimodal imaging, drug delivery, and catalysis. This progression, spanning over last decade, unfolded discernible phases, each marked by distinct advancements paradigm shifts. nascent stage, emphasis was placed on foundational techniques, such as ligand exchange organic coatings, establishing groundwork for subsequent innovations. review navigates through cutting-edge developments tailoring MNP surfaces, illuminating pivotal role advancing these diverse applications. The exploration encompasses an array innovative strategies inorganic encapsulation, engineering, self-assembly, bioconjugation, elucidating how approach impacts or augments performance. Notably, surface-functionalized MNPs exhibit increased efficacy demonstrating improved MRI contrast targeted imaging. current underscores transformative impact modifications delivery systems, enabling controlled release, therapy, enhanced biocompatibility. With a comprehensive analysis characterization techniques future prospects, this surveys dynamic landscape past three years (2021–2023). By dissecting underlying principles applications, provides not only retrospective but also forward-looking perspective potential surface-engineered shaping science, technology, medicine.
Язык: Английский
Процитировано
32
Frontiers in Pharmacology, Год журнала: 2023, Номер 13
Опубликована: Янв. 9, 2023
Background: Ultrasound-triggered sonodynamic therapy (SDT), as a non-invasive approach, has attracted considerable attention in wide variety of malignant tumors and other diseases. Over the past 2 decades, number scientific publications on SDT increased rapidly. However, there is still lack one comprehensive report that summarizes global research trends knowledge landscapes field detail. Thus, we performed bibliometric analysis from 2000 to 2021 track current hotspots highlight future directions. Methods: We collected Web Science Core Collection database. The annual citations, major contributors, popular journals, international collaborations, co-cited references co-occurrence keywords were analyzed visualized with CiteSpace, VOSviewer, R-bibliometrix. Results: A total 701 included. publication output 5 175 2021, average growth rate was 18.4%. China most productive country 463 documents (66.05%), Harbin Medical University prolific institution (N = 73). Ultrasound Medicine Biology published papers related SDT. Materials , Chemistry areas receiving interest. All divided into four different clusters including studies mechanisms, drug delivery nanoparticles, cancer therapy, well ultrasound sonosensitizers. In addition nanomaterials-related mesoporous silica nanosheets, liposomes, microbubble TiO nanoparticle, following directions such immunogenic cell death, metal-organic framework, photothermal hypoxia, tumor microenvironment, chemodynamic combination resistance, intensity focused ultrasound, delivery, Staphylococcus aureus also deserve further may continue explode future. Conclusion: bright treatment, nanomaterials have increasingly influenced development nano-technology. Overall, this study first attempt analyze SDT, which could provide valuable for later researchers better understand trends, frontiers domain.
Язык: Английский
Процитировано
29
Advanced Science, Год журнала: 2023, Номер 10(36)
Опубликована: Ноя. 1, 2023
Abstract Ribonucleic acid (RNA) drugs have shown promising therapeutic effects for various diseases in clinical and preclinical studies, owing to their capability regulate the expression of genes interest or control protein synthesis. Different strategies, such as chemical modification, ligand conjugation, nanotechnology, contributed successful translation RNA medicine, including small interfering (siRNA) gene silencing messenger (mRNA) vaccine development. Among these, nanotechnology can protect RNAs from enzymatic degradation, increase cellular uptake cytosolic transportation, prolong systemic circulation, improve tissue/cell targeting. Here, a focused overview stimuli‐responsive nanotechnologies delivery, which unique benefits promoting bioactivity cell/organ selectivity, is provided. Many tissue/cell‐specific microenvironmental features, pH, enzyme, hypoxia, redox, are utilized designing internal nanoparticles (NPs). In addition, external stimuli, light, magnetic field, ultrasound, also been used controlling release transportation. This review summarizes wide range NP systems may facilitate development next‐generation medicines.
Язык: Английский
Процитировано
25
Nano TransMed, Год журнала: 2024, Номер 3, С. 100042 - 100042
Опубликована: Июль 11, 2024
Novel drug delivery systems comprise sophisticated technology merged into systems. These are created with the aim of addressing limitations conventional For instance, inefficient in tackling challenging human diseases such as cancer. thus formed materials to enhance permeation target cells. They improve patients' compliance and efficacy. include self-powered microelectromechanical Nanotechnology is a rapidly growing promising field, especially system development disease therapy. often utilise nanocarriers due their numerous advantages. One benefits ability manipulate size surface functionalisation achieve site-specific targeting. Many researchers have reported controlled targeted release profiles. Nanocarriers propelled tissues, where entrapped drugs released, prolonging therapeutic efficacy decreasing undesired side effects. Hence, these offer delivery, low toxicity, high bioavailability improved efficiency. It essential understand mechanisms toxicity order develop efficient safe This review describes utilisation novel also dwells on loading, targeting from nanocarriers. The primary concerns clinical applications potential presented. expected that this will be helpful formulation seeking solutions cancer cardiovascular diseases.
Язык: Английский
Процитировано
11
European Polymer Journal, Год журнала: 2024, Номер 207, С. 112835 - 112835
Опубликована: Фев. 9, 2024
Язык: Английский
Процитировано
10
Drug Discovery Today, Год журнала: 2025, Номер unknown, С. 104292 - 104292
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106622 - 106622
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2022, Номер 14(1), С. 110 - 110
Опубликована: Янв. 4, 2022
The administration of cytotoxic drugs in classical chemotherapy is frequently limited by water solubility, low plasmatic stability, and a myriad secondary effects associated with their diffusion to healthy tissue. In this sense, novel pharmaceutical forms able deliver selectively these the malign cells, imposing space-time precise control discharge, are needed. last two decades, silica nanoparticles have been proposed as safe vehicles for antitumor molecules due stability physiological medium, high surface area easy functionalization, good biocompatibility. review, we focus on silica-based nanomedicines provided specific mechanisms intracellular drug release. According nature (amorphous, mesostructured, hybrids) nanocarriers responding variety stimuli endogenously (e.g., pH, redox potential, enzyme activity) or exogenously magnetic field, light, temperature, ultrasound) proposed. Furthermore, incorporation targeting monoclonal antibodies) that interact cell membrane receptors allows selective delivery cancer cells be carried out. Eventually, present some remarks most important formulations pipeline clinical approval, discuss difficult tasks tackle near future, order extend use real patients.
Язык: Английский
Процитировано
32
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 751 - 751
Опубликована: Фев. 23, 2023
Cancer is one of the major public health problems worldwide. Despite advances in cancer therapy, it remains a challenge due to low specificity treatment and development multidrug resistance mechanisms. To overcome these drawbacks, several drug delivery nanosystems have been investigated, among them, magnetic nanoparticles (MNP), especially superparamagnetic iron oxide (SPION), which applied for treating cancer. MNPs ability be guided tumor microenvironment through an external field. Furthermore, presence alternating field (AMF) this nanocarrier can transform electromagnetic energy heat (above 42 °C) Néel Brown relaxation, makes applicable hyperthermia treatment. However, chemical physical stability their coating necessary. Thus, lipid-based nanoparticles, liposomes, used encapsulate improve enable use as This review addresses main features that make most recent research nanomedicine using hybrid purpose.
Язык: Английский
Процитировано
18
Nano Research, Год журнала: 2023, Номер 16(5), С. 6974 - 6990
Опубликована: Янв. 14, 2023
Язык: Английский
Процитировано
17