Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101384 - 101384
Опубликована: Окт. 1, 2024
Язык: Английский
ACS symposium series, Год журнала: 2023, Номер unknown, С. 1 - 30
Опубликована: Март 17, 2023
Reaction to specific stimuli accurately is a fundamental procedure within living structures. Centered on this, stimuli-sensitive materials gained noticeable implications in the field of biomedicine owing flexible besides intriguing designs along diverse functioning. These have ability irreversible or reversible variations physical chemical characteristics reaction minor alterations inner external environment. Over last few years, are extensively engaged diagnosis, treatment, and sensors. responsive form basis construct smart systems, which perform required biomedicinal roles after getting particular stimuli. Subject type internal stimuli, could be categorized into numerous groups. This chapter outlines several with their recent progress biomedical applications. In foremost obstructions clinical future translation regarding such also been summarized.
Язык: Английский
Процитировано
17
Journal of Nanotheranostics, Год журнала: 2023, Номер 4(1), С. 55 - 85
Опубликована: Фев. 8, 2023
Currently, intelligent, responsive biomaterials have been widely explored, considering the fact that provide controlled and predictable results in various biomedical systems. Responsive nanostructures undergo reversible or irreversible changes presence of a stimulus, stimuli can be temperature, magnetic field, ultrasound, pH, humidity, pressure, light, electric etc. Different types being used drug delivery shall explained here. Recent research progress design, development applications comprising is also described More emphasis will given on explored for smart at target site such as wound healing, cancer therapy, inflammation, pain management order to achieve improved efficacy sustainability with lowest side effects. However, it still big challenge develop well-defined ordered output; thus, challenges faced during design these included this article. Clinical perspectives applicability targeted discussed
Язык: Английский
Процитировано
16
Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(4)
Опубликована: Янв. 26, 2024
This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables synergistic integration multiple treatment strategies. In particular, has enabled combination immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. each regimen, nanocarriers play multifaceted roles by achieving targeted codelivery different therapeutics individual modality. offers new paradigms guide precision medicine treatment. Immunotherapy alone unlikely achieve personalized cancer, are needed future. To overcome technical bottlenecks realize precise regulation tumor microenvironment treatment, it crucial develop novel nanosystems integrated sensing, targeting, functionalities.
Язык: Английский
Процитировано
6
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)
Опубликована: Фев. 27, 2024
Abstract Combinatorial immuno‐cancer therapy is recognized as a promising approach for efficiently treating malignant tumors. Yet, the development of multifunctional nanomedicine capable precise tumor targeting, remote activation, and immune‐regulating drug delivery remains significant challenge. In this study, nanoparticles loaded with an immune checkpoint inhibitor (JQ‐1) using polypyrrole/hyaluronic acid (PPyHA/JQ‐1) are developed. These offer active photothermal ablation near‐infrared light, laser‐controlled JQ‐1 release efficient breast cancer treatment. When molecular weight HA varies (from 6.8 kDa to 3 MDa) in PPyHA nanoparticles, it found that synthesized 1 MDa HA, referred (1 m ), show most suitable properties, including small hydrodynamic size, high surface contents, colloidal stability. Upon 808 nm laser irradiation, PPyHA/JQ‐1 elevates temperature above 55 °C, which sufficient thermal microenvironment (TME). Notably, controlled substantially inhibits expression cancer‐promoting genes. Furthermore, effectively suppresses programmed cell death ligand (PD‐L1) prolongs dendritic maturation CD8+ T activation against both vitro vivo. treatment simultaneously provides regression through blockade, leading durable antitumor‐immune response. Overall, “Three‐in‐one” immunotherapeutic photo‐activable have potential be beneficial targeted combinatorial TNBC.
Язык: Английский
Процитировано
6
Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101384 - 101384
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
6