Recent Advances in the Application of Engineered Exosomes from Mesenchymal Stem Cells for Regenerative Medicine

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177236 - 177236

Опубликована: Янв. 1, 2025

Язык: Английский

Exosomes in nanomedicine: a promising cell-free therapeutic intervention in burn wounds

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 9, 2024

Burn injuries are serious that have a big impact on person's health and can even cause death. Incurring severe burns incite an immune response inflammation within the body, alongside metabolic changes. It is of utmost importance to grasp fact effects burn injury extend beyond affecting mind overall well-being. long-lasting changes need be taken care in order improve their quality life. The intricate process skin regeneration at site wound involves complex dynamic interplay among diverse cells, growth factors, nerves, blood vessels. Exciting opportunities arisen field stem cells regenerative medicine, allowing us explore development cell-free-based alternatives aid treatment injuries. These therapies emerged as promising facet medicine. Exosomes, also referred naturally occurring nanoparticles, small endosome-derived vesicles facilitate delivery molecular cargo between thus intercellular communication. knowledge gained this has continued support therapeutic potential, particularly domains healing tissue regeneration. Notably, exosomes derived from mesenchymal (MSCs) safely administered system, which then adeptly uptaken internalized by fibroblasts/epithelial subsequently accelerating essential processes such migration, proliferation, collagen synthesis. Furthermore, released specifically macrophages, possess capability modulate effectively diminish it adjacent cells. Exosomes act carriers when integrated with scaffold, leading scarless cutaneous wounds. This comprehensive review examines role potential utility repair.

Язык: Английский

Application of mesenchymal stem cells in liver fibrosis and regeneration

Liver Research, Год журнала: 2024, Номер 8(4), С. 246 - 258

Опубликована: Ноя. 26, 2024

Язык: Английский