Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Май 19, 2025
Comprehensive Summary RNA modifications greatly expand the functional diversity of molecules, impacting RNA's stability, folding, and interactions with other biomolecules. These play critical roles in cellular processes are increasingly linked to disease states. Developments mass spectrometry (MS), nuclear magnetic resonance (NMR), chemical probing techniques have provided insights into mechanisms functions modifications. Combining these experimental approaches allows researchers explore complexities their effects on structure dynamics. This review highlights recent progresses field examines how integration MS, NMR, complementary is advancing our understanding biological significance. Key Scientists The landscape biology has undergone a dramatic transformation due development powerful methodologies that specifically target identification, characterization, analysis pioneered advancements (MS) (NMR) spectroscopy, enabling detailed study impact structure, dynamics, function. been instrumental revealing vast complexity modifications, demonstrating alterations molecules can profoundly influence processes. timeline contributions key figures who developed applied investigate significance potential disease.
Язык: Английский