Age-Related Oral and Para-Oral Tissue Disorders: The Evolving Therapeutic and Diagnostic Potential of Exosomes
Dentistry Journal,
Год журнала:
2025,
Номер
13(3), С. 106 - 106
Опубликована: Фев. 27, 2025
This
review
highlights
the
key
molecular
and
cellular
mechanisms
contributing
to
aging,
such
as
DNA
damage,
mitochondrial
dysfunction,
telomere
shortening,
protein
defective
autophagy.
These
biological
are
involved
in
various
oral
health
conditions
prevalent
elderly,
including
periodontal
disease,
cancer,
xerostomia,
dental
caries,
temporomandibular
joint
disorders.
Exosomes
generated
by
mesenchymal
stem
cells
possess
substantial
therapeutic
potential.
exosomes
nanosized
extracellular
vesicles
derived
from
essential
intercellular
communication
tissue
homeostasis.
The
exosome-based
therapies
proved
superior
traditional
cell-based
approaches,
due
lower
immunogenicity,
ease
of
storage,
avoidance
complications
associated
with
cell
transplantation.
Furthermore,
diagnostic
potential
non-invasive
biomarkers
for
aging
processes
age-related
diseases
offers
insights
into
disease
diagnosis,
staging,
monitoring.
Among
challenges
future
perspectives
translating
exosome
research
preclinical
studies
clinical
applications
is
need
standardized
procedures
fully
harness
capabilities
exosomes.
Язык: Английский
Regenerative Medicine in Plastic Surgery: The Role of Stem Cells and Bioprinting
Regenesis repair rehabilitation.,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Crosstalk Between Wnt/β-Catenin and Hedgehog Supports Gli1+ Lineage Osteogenesis in Cranial Sutures
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3508 - 3508
Опубликована: Апрель 9, 2025
Sutures
such
as
fibrous
joints
in
craniofacial
bones
provide
a
niche
for
Gli1+
mesenchymal
stem
cells
(MSCs)
promoting
calvarial
bone
development
and
growth.
However,
the
underlying
molecular
mechanism
behind
fate
of
Wnt/β-catenin
regulation
MSCs
during
formation
remains
unclear.
Here,
we
showed
that
β-catenin
was
colocalized
with
lineage
near
osteogenic
front
within
suture,
postnatal
skull
delayed
via
conditional
knockout
Ctnnb1
MSCs.
Calcein–Alizarin
Red
dual
staining
revealed
signal
inhibition
impaired
rate
formation.
Furthermore,
immunofluorescent
indicated
signaling
crucial
facilitating
proliferative
capacity
their
commitment
to
lineage.
Notably,
activating
hedgehog
(Hh)
partially
restored
suture
morphology
mice.
Collectively,
our
findings
crosstalk
between
Wnt
Hh
modulates
Язык: Английский
Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair
Bioengineering,
Год журнала:
2024,
Номер
11(11), С. 1100 - 1100
Опубликована: Окт. 31, 2024
Adipose-derived
stem
cells
(ADSCs)
have
emerged
as
a
promising
resource
for
craniofacial
bone
regeneration
due
to
their
high
abundance
and
easy
accessibility,
significant
osteogenic
potential,
versatile
applications,
potential
personalized
medicine,
which
underscore
importance
in
this
field.
This
article
reviews
the
current
progress
of
preclinical
studies
that
describe
careful
selection
specific
ADSC
subpopulations,
key
signaling
pathways
involved,
usage
various
strategies
enhance
ADSCs.
Additionally,
clinical
case
reports
regarding
application
ADSCs
repair
calvarial
defects,
cranio-maxillofacial
alveolar
defects
are
also
discussed.
Язык: Английский