Functional Yogurt: Types and Health Benefits
Applied Sciences,
Год журнала:
2024,
Номер
14(24), С. 11798 - 11798
Опубликована: Дек. 17, 2024
In
the
past
decade,
increasing
interest
in
healthy
consumption
has
encouraged
development
of
functional
products
yogurt
sector.
Dairy
are
extensively
used
production
foods
because
their
excellent
and
versatile
technological
properties.
Among
dairy
products,
is
one
that
been
most
widely
to
deliver
bioactive
compounds
consumers.
The
market
features
various
types
yogurt,
including
probiotic,
prebiotic,
synbiotic,
high
protein,
lactose
free,
novel
known
as
easy-to-digest
yogurt.
added
ingredients
these
influence
structural,
nutritional,
properties
These
effects
vary
depending
on
chemical
biological
characteristics
each
ingredient.
Additionally,
during
fermentation,
substances
can
impact
number
viability
bacteria
involved,
affecting
quality
storage.
Furthermore,
associated
with
health
benefits.
benefits
linked
not
only
supporting
but
also
altering
course
a
disease
or
alleviating
symptoms.
This
review
article
discusses
its
effects,
incorporating
recent
studies.
Язык: Английский
Fucosidosis: A Review of a Rare Disease
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 353 - 353
Опубликована: Янв. 3, 2025
Fucosidosis
is
a
rare
lysosomal
storage
disease
caused
by
α-L-fucosidase
deficiency
following
mutation
in
the
FUCA1
gene.
This
enzyme
responsible
for
breaking
down
fucose-containing
glycoproteins,
glycolipids,
and
oligosaccharides
within
lysosome.
Mutations
result
either
reduced
activity
or
complete
loss
of
function,
leading
to
accumulation
fucose-rich
substrates
lysosomes.
Lysosomes
become
engorged
with
undigested
substrates,
which
leads
secondary
defects
affecting
other
metabolic
pathways.
The
central
nervous
system
particularly
vulnerable,
dysfunction
causing
microglial
activation,
inflammation,
neuronal
loss,
neurodegenerative
symptoms
fucosidosis.
Neuroinflammation
contributes
damage,
including
apoptosis,
axonal
degeneration,
synaptic
dysfunction,
exacerbating
process.
Chronic
neuroinflammation
impairs
plasticity
survival,
progressive
intellectual
disability,
learning
difficulties,
previously
acquired
skills.
Inflammatory
cytokines
burden
motor
neurons
associated
pathways
contribute
ataxia,
spasticity,
hypotonia,
are
common
Elevated
neuroinflammatory
markers
can
increase
excitability,
frequent
occurrence
epilepsy
affected
individuals.
So,
fucosidosis
characterized
rapid
mental
along
growth
retardation,
coarse
facial
features,
hepatosplenomegaly,
telangiectasis
angiokeratomas,
epilepsy,
inguinal
hernia,
dysostosis
multiplex.
Patients
usually
die
at
an
early
age.
Treatment
great
challenge,
there
currently
no
definitive
effective
treatment.
Hematopoietic
cell
transplantation
studies
ongoing
treatment
However,
diagnosis
this
be
effective.
In
addition,
body’s
immune
decreases
due
chemotherapy
applied
after
transplantation,
leaving
body
vulnerable
microbes
infections,
risk
death
high
another
method,
gene
therapy,
use
retroviral
vectors,
promising
their
easy
integration,
efficiency,
safety.
approach,
replacement
preclinical
fucosidosis,
but
blood–brain
barrier
major
obstacle
diseases
system.
Early
important
disease,
delay
patients
identified
so
far
progression
disease.
carries
fewer
risks,
promising.
Язык: Английский
Advanced profiling and structural analysis of anencephaly gangliosides by ion mobility tandem mass spectrometry
Biochimie,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism
Biology Direct,
Год журнала:
2025,
Номер
20(1)
Опубликована: Март 19, 2025
Abstract
Background
N-glycosylation
is
a
complex,
post-translational
modification
which
influences
protein
function
and
sensitive
to
physiological
changes.
Obesity
associated
with
alterations
in
function;
however,
little
known
about
the
glycoproteome
obesity
beyond
observations
of
association
types
structures
selected
glycopeptides.
Most
often,
due
technical
challenges,
glycan
composition
structure
information
are
missing.
Here,
we
combined
label-free
data-independent
proteomics
targeted
quantitative
glycoproteomics
study
plasma
proteins
obesity.
Using
monozygotic
twin
design,
controlled
for
genetic
variation
focused
only
on
acquired
effects
Methods
samples
48
pairs
discordant
BMI
(intrapair
difference
>
2.5
kg/m
2
),
identified
using
mass
spectrometry,
differential
glycopeptide
levels
between
heavier
leaner
co-twins.
We
used
within-twin
paired
analysis
model
considered
p
<
0.05
as
significant.
Results
33
expression
differences
(
0.05)
These
occurred
either
both
glycoprotein
(sometimes
opposing
directions)
or
independently
from
each
other.
Haptoglobin
was
upregulated
(Fold
Change
=
1.10,
0.001)
co-twins
along
seven
compositions
at
site
Asn241.
The
complement
C3
1.08,
0.014)
one
Asn85.
Additionally,
many
glycopeptides
were
despite
non-significant
protein-backbone
levels.
Conclusion
Differential
related
cholesterol
biosynthesis
acute
phase
signalling
well
iron
metabolism
inflammation
can
be
linked
Язык: Английский
Unveiling the structural bases of α-L-fucosidase B activity through mutants boosting transfucosylation efficiency
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143462 - 143462
Опубликована: Апрель 1, 2025
Язык: Английский
Mechanisms and Potential Benefits of Neuroprotective Agents in Neurological Health
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4368 - 4368
Опубликована: Дек. 18, 2024
The
brain
contains
many
interconnected
and
complex
cellular
molecular
mechanisms.
Injury
to
the
causes
permanent
dysfunctions
in
these
So,
it
continues
be
an
area
where
surgical
intervention
cannot
performed
except
for
removal
of
tumors
repair
some
aneurysms.
Some
agents
that
can
cross
blood–brain
barrier
reach
neurons
show
neuroprotective
effects
due
their
anti-apoptotic,
anti-inflammatory
antioxidant
properties.
In
particular,
act
by
reducing
or
modulating
accumulation
protein
aggregates
neurodegenerative
diseases
(Alzheimer’s
disease,
Parkinson’s
Huntington’s
Amyotrophic
lateral
sclerosis,
prion
disease)
caused
accumulation.
Substrate
increased
oxidative
stress
stimulates
brain’s
immune
cells,
microglia,
astrocytes,
secrete
proinflammatory
cytokines.
Long-term
chronic
neuroinflammatory
response
triggers
apoptosis.
Brain
damage
is
observed
with
neuronal
apoptosis
functions
are
impaired.
This
situation
negatively
affects
processes
such
as
motor
movements,
memory,
perception,
learning.
Neuroprotective
prevent
molecules
play
a
role
addition,
they
improve
impaired
supporting
neuroplasticity
neurogenesis.
Due
important
roles
central
nervous
system
diseases,
elucidate
review
provides
overview
mechanisms
flavonoids,
which
constitute
large
part
effects,
well
vitamins,
neurotransmitters,
hormones,
amino
acids,
derivatives.
It
thought
understanding
will
enable
development
new
therapeutic
different
treatment
strategies.
Язык: Английский
Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition
Nutrients,
Год журнала:
2024,
Номер
17(1), С. 118 - 118
Опубликована: Дек. 30, 2024
Human
milk
oligosaccharides
(HMOs),
the
third
most
abundant
solid
component
in
human
milk,
vary
significantly
among
women
due
to
factors
such
as
secretor
status,
race,
geography,
season,
maternal
nutrition
and
weight,
gestational
age,
delivery
method.
In
recent
studies,
HMOs
have
been
shown
a
variety
of
functional
roles
development
infants.
Because
are
not
digested
by
infants,
they
act
metabolic
substrates
for
certain
bacteria,
helping
establish
infant’s
gut
microbiota.
By
encouraging
growth
advantageous
intestinal
these
sugars
function
prebiotics
produce
short-chain
fatty
acids
(SCFAs),
which
essential
health.
can
also
specifically
reduce
harmful
microbes
viruses
binding
epithelium,
preventing
illness.
HMO
addition
infant
formula
is
safe
promotes
healthy
development,
infection
prevention,
Current
formulas
frequently
contain
(OSs)
that
differ
structurally
from
those
found
making
it
unlikely
would
reproduce
unique
effects
HMOs.
However,
there
growing
trend
producing
OSs
resembling
HMOs,
but
limited
data
make
unclear
whether
offer
additional
therapeutic
benefits
compared
non-human
OSs.
Better
knowledge
how
mammary
gland
synthesizes
could
direct
technologies
yield
broad
complex
with
OS
compositions
closely
mimic
milk.
This
review
explores
HMOs’
nature
vital
role
health,
examining
variation
composition
its
contributing
factors.
It
highlights
technological
advances
enabling
large-scale
studies
on
Furthermore,
multifunctional
biological
processes
brain
microbiota
immune
response
regulation
investigated.
The
structural
distinctions
between
other
mammalian
discussed,
focus
toward
more
precise
replicas
Язык: Английский
Development of the infant’s microbiota depending on the nature of feeding: A review
Pediatrics Consilium Medicum,
Год журнала:
2024,
Номер
2, С. 106 - 111
Опубликована: Окт. 16, 2024
Breast
milk
oligosaccharides
(BMOs)
are
short
polymers
of
simple
sugars
that
present
in
high
concentrations
a
woman’s
breast
(BM).
Their
content
changes
fast
over
time.
Genetic
factors,
the
duration
lactation,
and
environmental
factors
particularly
influence
level
BMOs.
BMOs
can
facilitate
development
immune
system
protect
against
infectious
diseases
directly
through
interaction
intestinal
epithelial
cells
or
indirectly
modulation
microbiota,
including
stimulating
Bifidobacterium
growth.
Clinical
data
suggest
adding
to
infant
formula
promotes
normal
neonatal
growth
benefits
health.
Adding
1
2
formulas
is
safe
brings
their
composition
closer
BM,
allowing
child
develop
harmoniously.
Язык: Английский
Bovine Colostrum in Pediatric Nutrition and Health
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4305 - 4305
Опубликована: Дек. 13, 2024
Bovine
colostrum
(BC),
the
first
milk
secreted
by
mammals
after
birth,
is
a
trending
alternative
source
for
supplementing
infants
and
children,
offering
benefits
gut
immune
health.
Its
rich
components,
such
as
proteins,
immunoglobulins,
lactoferrin,
glycans,
are
used
to
fortify
diets
support
development.
Preterm
development
crucial,
especially
in
maturation
of
essential
systems,
from
2010
2020,
approximately
15%
all
premature
births
occurred
at
less
than
32
weeks
gestation
worldwide.
This
review
explores
composition,
benefits,
effects
BC
on
general
along
with
preterm
who
require
special
care,
highlights
its
role
growth
also
associated
specific
pediatric
diseases,
including
necrotizing
enterocolitis
(NEC),
infectious
diarrhea,
inflammatory
bowel
disease
(IBD),
short-bowel
syndrome
(SBS),
neonatal
sepsis,
gastrointestinal
respiratory
infections,
some
minor
conditions.
discusses
clinical
trials
regarding
these
conditions
which
occasionally
encountered
infants.
The
anti-inflammatory,
antimicrobial,
immunomodulatory,
antiviral
properties
discussed,
emphasizing
mechanisms
action.
Clinical
trials,
particularly
humans,
provide
evidence
supporting
inclusion
formulas
diets,
although
precise
standards
age,
feeding
time,
amounts
needed
ensure
safety
efficacy.
However,
potential
adverse
effects,
allergic
reactions
caseins
immunoglobulin
E,
must
be
considered.
More
comprehensive
necessary
expand
infant
feeding,
important
components
BC,
should
further
studied
their
synergistic
diseases.
Ultimately,
shows
promise
health
incorporated
into
nutritional
supplements
caution.
Язык: Английский
Postnatal Development of Blood Group Antigens and Antibodies in the First Year of Life
WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE,
Год журнала:
2024,
Номер
22, С. 82 - 93
Опубликована: Дек. 13, 2024
Blood
group
antigens
are
biological
markers
in
a
large
part
of
human
tissues;
therefore,
their
study
is
critical
from
the
point
view
biomedicine.
It
interesting
to
investigate
unique
characteristics
antigen
expression
ABO
system
an
ontogenetic
perspective.
As
previously
stated,
these
carbohydrate-based.
The
full
production
involves
multiple
stages,
and
complete
depends
on
specific
stages
prenatal
postnatal
development.
Some
researchers
have
revealed
that
they
weakly
expressed
newborns,
group-specific
antibodies
not
found
majority
studied
newborns.
Our
current
about
evaluation
qualitative
quantitative
system’s
antibody
first
year
period.
A
total
202
samples
infants
aged
28
days
12
months
were
used
for
study.
Among
them,
there
94
females
(46.54±3.5%)
108
males
(53.46±3.5%).
materials
obtained
M.
Iashvili
Batumi
Maternal
Child
Central
Hospital.
main
criterion
inclusion
was
age
infants,
particular,
research
sorted
into
two
groups:
1.
6
(n=89)
and;
2.
(n=113).
Qualitative
analyzed
at
Immunogenetics
Laboratory
Biosafety
laboratories
Shota
Rustaveli
State
University.
relied
immunoserological
method
visually
detect
agglutination
reactions.
Standard
erythrocytes
groups
B
antibodies,
anti-A,
anti-B,
anti-D
monoclonal
blood
A,
B,
D
antigens.
In
our
group,
represented
following
order:
O
>
A>
AB,
which
corresponds
population
parameters
mentioned
region.
74.80±3.9%
carry
antigen,
with
41.57±3.4%
belonging
A(II)
(n=84)
3.96±1.8%
AB
(IV)
(n=8).
important
note
we
simultaneously
screened
subgroups
within
phenotypic
groups.
Around
52.17%
(±5.2%)
phenotype
A1
subgroup
(n=48),
39.13%
(±5.0%)
A2
(n=36).
individuals
phenotype,
both
A1B
A2B
occur
equal
frequency
approximately
4.35%
(±2.1%).
Since
people
(I)
anti-A
anti-B
plasma,
this
characteristic
91
newborns
group.
Where,
38.46±5.0%
had
(n=35),
indicator
increased
by
1.28
times
months,
1.93
(approximately
2
times)
6-12
months.
We
peculiarities
synthesis
during
Based
results
it
should
be
noted
developmental
profile
very
similar
adults
compared
newborn
profile.
However,
some
circumstances,
specificity
detection
differs
adults.
data,
propose
reversed
typing
employed
joint
screening
antigen-antibodies
above-mentioned
especially
also
suggested
phenotypes
serology
period
development
required
exhibits
mimicry
serologically,
shifting
trait
stage
ontogenesis.
Rh
manifestation
infants.
planned
next
(2nd
development)
order
determine
when
occurs.
would
conduct
other
regions
too.
Because
differ
each
based
climate,
diet,
infections,
can
influence
synthesis.
Язык: Английский