A Comprehensive Machine Learning Approach for COVID-19 Target Discovery in the Small-Molecule Metabolome
Metabolites,
Год журнала:
2025,
Номер
15(1), С. 44 - 44
Опубликована: Янв. 11, 2025
Background/Objectives:
Respiratory
viruses,
including
Influenza,
RSV,
and
COVID-19,
cause
various
respiratory
infections.
Distinguishing
these
viruses
relies
on
diagnostic
methods
such
as
PCR
testing.
Challenges
stem
from
overlapping
symptoms
the
emergence
of
new
strains.
Advanced
diagnostics
are
crucial
for
accurate
detection
effective
management.
This
study
leveraged
nasopharyngeal
metabolome
data
to
predict
virus
scenarios
control
vs.
Influenza
A,
all
COVID-19
A/RSV.
Method:
We
proposed
a
stacking-based
ensemble
technique,
integrating
top
three
best-performing
ML
models
initial
results
enhance
prediction
accuracy
by
leveraging
strengths
multiple
base
learners.
Key
techniques
feature
ranking,
standard
scaling,
SMOTE
were
used
address
class
imbalances,
thus
enhancing
model
robustness.
SHAP
analysis
identified
metabolites
influencing
positive
predictions,
thereby
providing
valuable
insights
into
markers.
Results:
Our
approach
not
only
outperformed
existing
but
also
revealed
dominant
features
predicting
Lysophosphatidylcholine
acyl
C18:2,
Kynurenine,
Phenylalanine,
Valine,
Tyrosine,
Aspartic
Acid
(Asp).
Conclusions:
demonstrates
effectiveness
scenarios.
The
enhances
accuracy,
provides
key
markers,
offers
robust
framework
managing
Язык: Английский
Artificial Intelligence in Cybersecurity: A Comprehensive Review and Future Direction
Applied Artificial Intelligence,
Год журнала:
2024,
Номер
38(1)
Опубликована: Дек. 10, 2024
As
cybercrimes
are
becoming
increasingly
complex,
it
is
imperative
for
cybersecurity
measures
to
become
more
robust
and
sophisticated.
The
crux
lies
in
extracting
patterns
or
insights
from
data
build
data-driven
models,
thus
making
the
security
systems
automated
intelligent.
To
comprehend
analyze
data,
several
Artificial
Intelligence
(AI)
methods
such
as
Machine
Learning
(ML)
techniques,
employed
monitor
network
environments
actively
combat
cyber
threats.
This
study
explored
various
AI
techniques
how
they
applied
cybersecurity.
A
comprehensive
literature
review
was
conducted,
including
a
bibliometric
analysis
systematic
following
PRISMA
(Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses)
guidelines.
Using
extracted
two
main
scholarly
databases:
Clarivate's
Web
of
Science
(WoS)
Scopus,
this
article
examines
relevant
academic
understand
diverse
ways
which
strengthen
measures.
These
applications
range
anomaly
detection
threat
identification
predictive
analytics
incident
response.
total
14,509
peer-reviewed
research
papers
were
identified
9611
Scopus
database
4898
WoS
database.
further
filtered,
939
eventually
selected
used.
offers
into
effectiveness,
challenges,
emerging
trends
utilizing
purposes.
Язык: Английский