
International Journal of Medical Sciences, Год журнала: 2025, Номер 22(8), С. 1979 - 1991
Опубликована: Март 29, 2025
Pulmonary hypertension (PH) is a vascular disease characterized by remodeling of the pulmonary arteries and right heart failure. Chronic obstructive (COPD) patients often have PH, which can worsen symptoms raise morbidity mortality. There are several reasons for increased resistance, remodeling, ultimately development PH in COPD. These factors include genetics, inflammation caused chemicals breathed, changes alveoli seen COPD its physiology. Genes involved mRNA conversion, subcellular localization, splicing, translation all finely tuned RBPs their post-transcriptional regulation. Erythropoietin regulates cytokines, chemokines, proteins, growth factors, other pro-inflammatory mediators that change lung microenvironment. Over past few years, we learned more about how act Here, discuss existing understanding RBPs' location same pathogenic pathways shared order to emphasize potential relevance as determinant/biomarker and, consequently, possible therapeutic targeting.
Язык: Английский