Copper Complexes with New Glycyl-l-histidyl-l-lysine–Hyaluronan Conjugates Show Antioxidant Properties and Osteogenic and Angiogenic Synergistic Effects
Bioconjugate Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
In
recent
years,
hyaluronic
acid
(HA)
and
the
natural
tripeptide
glycyl-l-histidyl-l-lysine
(GHK),
especially
its
copper(II)
complex
(GHK-Cu),
individually
have
been
shown
to
exert
helpful
properties
for
bone
protection
regeneration.
However,
they
are
not
strong
enough
handle
oxidative
stress,
hydrolytic
attack,
or
environmental
conditions.
Being
aware
that
conjugation
chemistry
has
recently
emerged
as
an
appealing
approach
generating
new
molecular
entities
capable
of
preserving
integrity
their
moieties
delaying
degradation,
herein
we
present
synthesis
conjugates
HA
with
GHK
(GHK-HA),
at
different
loadings
tripeptide.
GHK-HA
binds
ions
potentiates
chemical
biological
two
components
in
vitro
assays.
The
results
highlight
copper's
role
promoting
expression
release
certain
trophic,
angiogenic,
osteogenic
factors,
including
brain-derived
neurotrophic
factor
(BDNF),
vascular
endothelial
growth
(VEGF),
well
morphogenetic
protein-2
(BMP-2).
protective
regenerative
activities
metal
ion
related
translocation
intracellular
chaperones
Copper
Chaperone
Superoxide
Dismutase
(CCS)
Antioxidant-1
(Atox1)
nucleus
where
act
transcription
factors.
Язык: Английский
The Regulation of Trace Metal Elements in Cancer Ferroptosis
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Abstract
Ferroptosis,
as
novel
type
of
regulated
cell
death
that
has
garnered
widespread
attention
over
the
past
decade,
witnessed
continuous
discovery
an
increasing
number
regulatory
mechanisms.
Trace
metal
elements
play
a
multifaceted
and
crucial
role
in
oncology.
Interestingly,
it
been
increasingly
evident
these
elements,
such
copper,
are
involved
regulation
iron
accumulation,
lipid
peroxidation
antiferroptotic
systems,
suggesting
existence
“nonferrous”
mechanisms
ferroptosis.
In
this
review,
comprehensive
overview
composition
mechanism
ferroptosis
is
provided.
The
interaction
between
copper
metabolism
(including
cuproptosis)
cancer,
well
roles
other
trace
(such
zinc,
manganese,
cobalt,
molybdenum)
specifically
focused.
Furthermore,
applications
nanomaterials
based
on
metals
cancer
therapy
also
reviewed
potential
strategies
for
co‐targeting
cuproptosis
explored.
Nevertheless,
light
intricate
ambiguous
nature
interactions,
ongoing
research
essential
to
further
elucidate
ferroptosis,
thereby
facilitating
development
therapeutic
targets
approaches
treatment.
Язык: Английский
Cuproptosis and its potential role in musculoskeletal disease
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 11, 2025
Cuproptosis,
a
recently
identified
form
of
copper-dependent
cell
death,
arises
from
intracellular
copper
dyshomeostasis.
As
an
essential
trace
element,
plays
critical
role
in
bioenergetic
metabolism,
redox
regulation,
and
synaptic
transmission.
However,
excessive
exerts
cytotoxic
effects
through
multiple
pathways,
including
increased
reactive
oxygen
species
(ROS)
production,
apoptotic
cascade
activation,
necrotic
membrane
rupture,
inflammatory
responses,
mitochondrial
dysfunction.
Distinct
other
death
mechanisms,
cuproptosis
is
characterized
by
ion
binding
to
acetylated
respiratory
chain
proteins,
leading
pathogenic
protein
aggregation,
iron-sulfur
cluster
depletion,
cellular
collapse.
Emerging
evidence
underscores
aberrant
accumulation
resultant
proteotoxic
stress
as
pivotal
contributors
the
pathogenesis
musculoskeletal
pathologies,
osteoporosis,
osteoarthritis,
sarcopenia,
osteosarcoma,
intervertebral
disc
degeneration,
spinal
cord
injury,
biofilm-associated
orthopedic
infections.
Understanding
spatiotemporal
regulation
may
provide
novel
opportunities
for
advancing
diagnostic
therapeutic
approaches
medicine.
This
review
synthesizes
current
insights
into
molecular
mechanisms
cuproptosis,
its
diseases,
potential
biomarker-driven
interventions.
Язык: Английский