Long COVID prevalence and impact on quality of life 2 years after acute COVID-19

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Июль 11, 2023

There has been an increasing interest in the long-term impact of long COVID. However, only a few studies have investigated clinical manifestations COVID after 24 months acute infection. In this study, prospective online surveys were conducted adults previously diagnosed with coronavirus disease 2019 (COVID-19) South Korea between February 13 and March 13, 2020, at 6, 12, COVID-19. We self-reported symptoms EuroQol-5-dimension index. Among 900 individuals enrolled initially, 150 completed all 3 surveys. After excluding cases COVID-19 reinfection, 132 included final analysis. participants, 94 (71.2%) experienced The most frequently reported fatigue (34.8%), amnesia (30.3%), concentration difficulties (24.2%), insomnia (20.5%), depression (19.7%). Notably, no significant differences noted incidence terms number vaccinations received. Although neuropsychiatric quality life improved over time, it continued to affect 32.7% participants. Symptoms COVID, particularly symptoms, tend persist vaccination or received may not significantly

Язык: Английский

---

Importance of Magnesium Status in COVID-19

Biology, Год журнала: 2023, Номер 12(5), С. 735 - 735

Опубликована: Май 18, 2023

A large amount of published research points to the interesting concept (hypothesis) that magnesium (Mg) status may have relevance for outcome COVID-19 and Mg could be protective during COVID disease course. As an essential element, plays basic biochemical, cellular, physiological roles required cardiovascular, immunological, respiratory, neurological functions. Both low serum dietary been associated with severity outcomes, including mortality; both are also risk factors such as older age, obesity, type 2 diabetes, kidney disease, cardiovascular hypertension, asthma. In addition, populations high rates mortality hospitalization tend consume diets in modern processed foods, which generally Mg. this review, we review describe consider possible impact on showing (1) between 2.19 2.26 mg/dL intakes > 329 mg/day course (2) inhaled improve oxygenation hypoxic patients. spite promise, oral has thus far studied only combination other nutrients. deficiency is involved occurrence aggravation neuropsychiatric complications COVID-19, memory loss, cognition, loss taste smell, ataxia, confusion, dizziness, headache. Potential zinc and/or useful increasing drug therapy effectiveness or reducing adverse effect anti-COVID-19 drugs reviewed. Oral trials patients warranted.

Язык: Английский

---

Subjective attitudes moderate the social connectedness in esports gaming during COVID-19 pandemic: A cross-sectional study

Frontiers in Public Health, Год журнала: 2023, Номер 10

Опубликована: Янв. 4, 2023

Electronic sports (esports) has become a practical intervention for young people craving social connections since the COVID-19 pandemic. Past studies have shown an equivocal role of esports participation in boosting ties or connectedness. It is unclear if their relationship affected by subjective attitudes gamers. Moreover, present pandemic may further modify this to greater extent.

Язык: Английский

---

Neurexin dysfunction in neurodevelopmental and neuropsychiatric disorders: a PRIMSA-based systematic review through iPSC and animal models

Frontiers in Behavioral Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Фев. 6, 2024

Background Neurexins, essential synaptic proteins, are linked to neurodevelopmental and neuropsychiatric disorders like autism spectrum disorder (ASD) schizophrenia. Objective Through this systematic review, we aimed shed light on the relationship between neurexin dysfunction its implications in manifestations. Both animal human-induced pluripotent stem cell (hiPSC) models served as our primary investigative platforms. Methods Utilizing PRISMA 2020 guidelines, search strategy involved scouring articles from PubMed Google Scholar databases covering a span of two decades (2003–2023). Of initial collection, 27 rigorously evaluated studies formed essence review. Results Our review suggested significant ties anomalies outcomes, most notably ASD. Rodent-based investigations delineated pronounced ASD-associated behaviors, hiPSC derived ASD-diagnosed patients revealed disruptions calcium dynamics activities. Additionally, underlined integral role specific variants, primarily NRXN1, pathology It was also evident observation that malfunctions were implicated broader array these disorders, including ADHD, intellectual challenges, seizure disorders. Conclusion This accentuates cardinal neurexins play pathological process The findings underscore critical need for standardized methodologies developing future studies, aiming minimize heterogeneity. Moreover, highlight expand research into less studied variants (i.e., NRXN2 NRXN3), broadening scope understanding field. projects potent tools bridging gaps, promoting translational research, fostering development patient-specific therapeutic interventions.

Язык: Английский

---

Cognitive function and quantitative electroencephalogram analysis in subjects recovered from COVID-19 infection

BMC Neurology, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 10, 2024

Abstract Background & Objectives Objective assessment of post-COVID-19 cognitive dysfunction is highly warranted. This study aimed to evaluate the COVID-19 survivors with complaints, both clinically and neurophysiologically, using Quantitative Electroencephalogram (QEEG). Methods case–control was conducted on 50 recovered subjects from infection complaints age, sex, educational-matched healthy controls. Both groups were subjected following neurocognitive tests: Paired associate learning Test (PALT) Paced Auditory Serial Addition (PASAT). The neurophysiological also done for QEEG. Results had significantly lower PALT scores than controls ( P < 0.001). QEEG analysis found higher levels Theta / Beta ratio in central parietal areas patients 0.001 each). interhemispheric coherence frontal, central, regions control group regarding alpha beta bands. There statistically significant PASAT among cases severe = 0.011, 0.005 , respectively) those who needed oxygen support 0.04, 0.01, respectively). On other hand, a mean frontal inter-hemispheric 0.01) needing mechanical ventilation 0.04). Conclusion Episodic memory deficit evident subjective accompanied by regions. These clinical changes are associated hypoxia severity.

Язык: Английский

---

Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis

BMC Geriatrics, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 14, 2024

Abstract Background The relationship between COVID-19 infection and a possible increased likelihood of older adults developing new-onset dementia (NOD) remains elusive. Methods A thorough search was performed across several databases including MEDLINE/PubMed, PsycINFO, Scopus, medRxiv, PQDT Global for studies published in English from January 2020 to December 2023. Only original investigations exploring the link NOD were selected inclusion. We assessed risk NOD, using Risk Ratio (RR) measurement. Control groups categorized as: (i) non-COVID cohort with other respiratory infections [control group (C1)]; (ii) otherwise unspecified health status (C2)]. Follow-up periods divided into intervals 3, 6, 12, 24 months post-COVID. Results 11 (involving 939,824 post-COVID-19 survivors 6,765,117 controls) included review. Across median observation period 12 post-COVID, overall incidence about 1.82% COVID-infected group, compared 0.35% non-COVID-infected group. pooled meta-analysis showed significantly among adult non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). Similar risks observed subgroup analyses restricted an observational 1.56, 1.21–2.01), as well five that employed propensity score matching sufficiently effectively control multiple confounding covariates 1.46, 1.10–1.94). C1 shared comparably (overall RR 1.13, 0.92–1.38). Discussion Under normal circumstances, we believe is likely be factor over time. While due appears similar associated infections, it warrants necessitates investigation longer observations.

Язык: Английский

---

Characterization of cognitive symptoms in post COVID-19 patients

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Май 13, 2024

Abstract Cognitive symptoms (CS) belong to the most common manifestations of Post COVID-19 (PC) condition. We sought objectify CS in PC patients using routine diagnostic assessments: neurocognitive testing (NCT) and brain imaging (BI). Further, we investigated possible associations with patient reported outcomes (PROs), risk factors for developing CS. Clinical data PROs 315 were assessed at a mean 6 months after SARS-CoV-2 infection. 231 (73.3%) any sort Among them, 78 underwent NCT 55 received BI. In NCT, cognitive domains affected working memory, attention, concentration. Nonetheless, pathological thresholds exceeded only few cases. Neurocognitive performance did not differ significantly between complaining severe (n = 26) versus non-severe 52) BI findings abnormal 8 (14.5%) cases but likely related PC. Patients reporting high severity scored worse PHQ-9, FSS, WHOQOL-BREF, more report impaired sleep, had higher prevalence psychiatric diagnoses. Overall, could confirm mild impairment some all CS, while studies affect results, associated depression (PHQ-9), fatigue (FSS), reduced quality life (WHOQOL-BREF) illnesses. These support importance BI, neuro-psychological assessment work-up Trial registration number date registration: DRKS00030974, 22 Dec 2022, retrospectively registered.

Язык: Английский

---

Health Resort Treatment Mitigates Neuropsychiatric Symptoms in Long COVID Patients: A Retrospective Study

Healthcare, Год журнала: 2025, Номер 13(2), С. 196 - 196

Опубликована: Янв. 19, 2025

Background/Objectives: Among the neuropsychiatric symptoms of long COVID, following may be listed: sleep disturbances, headaches, anxiety, depression, dizziness, numbness, memory loss, and concentration difficulties. Various therapies have been implemented to mitigate these symptoms; however, health resort treatments that utilize a wide range modalities stimulating multidirectional biological reactions also effective. The aim this study was assess severity in COVID patients who qualified for treatment, evaluate effectiveness treatment group patients, effect balneological factors course. Methods: A retrospective analysis medical records 120 people with (69 women 51 men) aged 42–79 underwent 2021 performed. People were eligible at lowland based on valid referral from doctor. included therapies, physical medicine modalities, exercise programs, education, psychological support. Patients assessed persistent 0–10 point scale before after treatment. Results: After greatest improvement noted disorders (2.47 ± 2.23 points vs. 0.86 1.25 points, p < 0.00001) dizziness (1.39 1.94 0.34 0.76 0.00001). lowest observed (2.68 2.5 1 1.4 Conclusions: reported mild symptoms. Health mitigates symptoms, as it is complex approach. Treatment includes improves greater extent. This method should integrated into standard COVID.

Язык: Английский

---

The Relationship between Cognitive Function and Neuropsychiatric Disorders with Quantitative Electroencephalogram (qEEG) on Long COVID Syndrome Patients

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 100954 - 100954

Опубликована: Янв. 1, 2025

Язык: Английский

---

Commentary to the article: “Acute and long-term effects of COVID-19 on brain and mental health: A narrative review”

Brain Behavior and Immunity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

---