Journal of Ethnopharmacology, Год журнала: 2023, Номер 323, С. 117679 - 117679
Опубликована: Дек. 29, 2023
SuanZaoRen Decoction (SZRD), a famous herbal prescription, and has been widely proven to have positive therapeutic effects on insomnia, depression Alzheimer's disease (AD). However, the anti-AD molecular mechanism of SZRD remains be further investigated.
Язык: Английский
Advanced Science, Год журнала: 2023, Номер 10(24)
Опубликована: Июнь 21, 2023
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality is morphologically and mechanistically different from other forms of death, plays vital role in the pathophysiological process neurodegenerative diseases, strokes. Accumulating supports ferroptosis as critical factor diseases strokes, pharmacological inhibition therapeutic target for these diseases. In this review article, core mechanisms are overviewed roles strokes described. Finally, emerging findings treating through This demonstrates by bioactive small-molecule compounds (ferroptosis inhibitors) could be effective treatments highlights potential promising avenue used to prevent article will shed light on developing novel regimens slow down progression future.
Язык: Английский
Процитировано
81
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114312 - 114312
Опубликована: Май 19, 2023
Neurodegenerative diseases, such as Alzheimer's disease (AD), are characterized by massive loss of specific neurons. It is a progressive disabling, severe and fatal complex disease. Due to its pathogenesis limitations clinical treatment strategies, it poses serious medical challenge burden worldwide. The AD not clear, potential biological mechanisms include aggregation soluble amyloid form insoluble plaques, abnormal phosphorylation tau protein formation intracellular neurofibrillary tangles (NFT), neuroinflammation, ferroptosis, oxidative stress metal ion disorders. Among them, ferroptosis newly discovered programmed cell death induced iron-dependent lipid peroxidation reactive oxygen species. Recent studies have shown that closely related AD, but the mechanism remains unclear. may be iron metabolism, amino acid metabolism affecting accumulation ions. Some chelating agents (deferoxamine, deferiprone), chloroiodohydroxyquine derivatives, antioxidants (vitamin E, lipoic acid, selenium), derivatives Fer-1, tet, etc. been in animal effective exert neuroprotective effects. This review summarizes regulation natural plant products on order provide reference information for future research development inhibitors.
Язык: Английский
Процитировано
46
Archives of Toxicology, Год журнала: 2024, Номер 98(3), С. 579 - 615
Опубликована: Янв. 24, 2024
Abstract This article provides an overview of the background knowledge ferroptosis in nervous system, as well key role nuclear factor E2-related 2 (Nrf2) regulating ferroptosis. The takes Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), and amyotrophic lateral sclerosis (ALS) starting point to explore close association between Nrf2 ferroptosis, which is clear significant importance for understanding mechanism neurodegenerative diseases (NDs) based on oxidative stress (OS). Accumulating evidence links pathogenesis NDs. As progresses, damage antioxidant excessive OS, altered expression levels, especially inhibition by lipid peroxidation inhibitors adaptive enhancement signaling, demonstrate potential clinical significance detecting identifying targeted therapy neuronal loss mitochondrial dysfunction. These findings provide new insights possibilities treatment prevention
Язык: Английский
Процитировано
26
BioFactors, Год журнала: 2024, Номер 50(4), С. 693 - 708
Опубликована: Янв. 16, 2024
Abstract Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological have shown limited efficacy are associated with side effects. Approaches focusing on the early interference pathways, before activation of broad processes, could be promising slow down symptomatic progression disease. Curcumin—an integral component traditional medicine in numerous cultures worldwide—has garnered interest as AD treatment. research indicates that curcumin may exhibit potential pathologies, attributed its potent anti‐inflammatory antioxidant properties. Additionally, derivatives demonstrated an ability modulate cellular pathways via epigenetic mechanisms. This article aims raise awareness neuroprotective properties curcuminoids provide benefits AD. paper provides comprehensive overview against signaling involved summarizes recent evidence biological efficiency curcumins vivo.
Язык: Английский
Процитировано
20
Cellular and Molecular Neurobiology, Год журнала: 2024, Номер 44(1)
Опубликована: Фев. 23, 2024
Iron deposition is crucial pathological changes observed in patients with Parkinson's disease (PD). Recently, scientists have actively explored therapeutic approaches targeting iron PD. However, several clinical studies failed to yield consistent results. In this review, we provide an overview of PD, from both basic research and perspectives. PD exhibit abnormalities various metabolism-related proteins, leading disruptions distribution, transport, storage, circulation, ultimately resulting deposition. Excess can induce oxidative stress iron-related cell death, exacerbate mitochondrial dysfunction, contributing the progression pathology. Magnetic resonance imaging indicated that characteristics brains vary. correlates symptoms different courses presentations display distinct patterns These may contribute diagnosis. a promising target for treatment. further required elucidate underlying mechanisms their impacts on
Язык: Английский
Процитировано
20
Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14
Опубликована: Сен. 1, 2022
Sleep deprivation (SD) is one of the main risk factors for Alzheimer's disease (AD), but underlying mechanism still unclear. Ketogenic diet (KD) has been shown widely neuroprotective effects less known about its effect on SD-induced AD. In present study, a continuous 21 days SD mouse model with or without KD was established. The changes cognitive function, pathological hallmarks AD, ferroptosis, and intracellular signal pathways in mice were detected by Morris water maze, ThS staining, diaminobenzidine (DAB)-enhanced Perls' stain, antioxidant assay, immuno-histochemistry, western blot. results showed that can prevent deficiency, amyloid deposition hyperphosphorylated tau induced chronic SD. Analysis ferroptosis revealed inhibit iron dyshomeostasis down-regulating expression TfR1 DMT1 up-regulating FTH1, FPN1. Meanwhile, alleviated oxidative stress elevated xCT/GPX4 axis, FSP1 reduced MDA. addition, could promote neuronal repair enhancing BDNF DCX. Further studies demonstrated activated Sirt1/Nrf2 signaling pathway hippocampus SD-exposed mice. Our finding firstly suggested AD inhibiting improving ability via pathway.
Язык: Английский
Процитировано
42
Journal of Neural Transmission, Год журнала: 2023, Номер 130(5), С. 627 - 646
Опубликована: Апрель 16, 2023
Abstract Since the description of some peculiar symptoms by James Parkinson in 1817, attempts have been made to define its cause or at least enlighten pathology “Parkinson’s disease (PD).” The vast majority PD subtypes and most cases sporadic share Lewy bodies (LBs) as a characteristic pathological hallmark. However, processes underlying LBs generation causal triggers are still unknown. ɑ-Synuclein (ɑ-syn, encoded SNCA gene) is major component LBs, missense mutations duplications/triplications for rare hereditary forms PD. Thus, it imperative study ɑ-syn protein pathology, including oligomerization, fibril formation, aggregation, spreading mechanisms. Furthermore, there synergistic effects pathogenic mechanisms PD, multiple factors—contributing with different ratios—appear be progression factors. For example, oxidative stress, reduced antioxidative capacity, mitochondrial dysfunction, proteasomal disturbances each suggested formation aggregation contribute neuroinflammation neural cell death. Aging also risk factor Iron, well neuromelanin (NM), show age-dependent increases, iron significantly increased Parkinsonian substantia nigra (SN). Iron-induced include changes molecular structure ɑ-syn. more recent research demonstrates that (i) detected not only dopaminergic neurons glia but various neurotransmitter systems, (ii) sympathetic nerve fibres degenerate first, (iii) “brain-first” deficiency evident before induced NM. These findings support ɑ-syn/LBs iron- NM-induced important facts via their interaction potentiate process SN. As such, multifactorial toxic posted on personal genetic assumed neurodegenerative Differences ratios factors spatiotemporal development, fact common hard identify, imply existence several phenotypical subtypes, which supported arguments from both “bottom-up/dual-hit” models. Therapeutic strategies necessary avoid single initiation leading
Язык: Английский
Процитировано
32
Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102309 - 102309
Опубликована: Апрель 13, 2024
Язык: Английский
Процитировано
14
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102210 - 102210
Опубликована: Фев. 1, 2024
Alzheimer's disease (AD) is a major global health problem today and the most common form of dementia. AD characterized by formation β-amyloid (Aβ) plaques neurofibrillary clusters, leading to decreased brain acetylcholine levels in brain. Another mechanism underlying pathogenesis abnormal phosphorylation tau protein that accumulates at level aggregates, areas affected this pathological process are usually cholinergic neurons cortical, subcortical, hippocampal areas. These effects result cognitive function, atrophy, neuronal death. Malnutrition weight loss frequent manifestations AD, these also associated with greater decline. Several studies have confirmed balanced low-calorie diet proper nutritional intake may be considered important factors counteracting or slowing progression whereas high-fat hypercholesterolemic predisposes an increased risk developing AD. Especially, fruits, vegetables, antioxidants, vitamins, polyunsaturated fatty acids, micronutrients supplementation exert positive on aging-related changes due their antioxidant, anti-inflammatory, radical scavenging properties. The purpose review summarize some possible contribute prevention understand role nutrition plays Aβ typical neurodegenerative disease, identify potential therapeutic strategies involve natural compounds, delaying disease.
Язык: Английский
Процитировано
12
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130387 - 130387
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
10