International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14954 - 14954
Опубликована: Окт. 6, 2023
Alzheimer's
disease
(AD)
is
one
of
the
most
prevalent
neurodegenerative
diseases
and
a
major
contributor
to
dementia.
Although
cause
this
condition
has
been
identified
long
ago
as
aberrant
aggregations
amyloid
tau
proteins,
effective
therapies
for
it
remain
elusive.
The
complexities
drug
development
AD
treatment
are
often
compounded
by
impermeable
blood-brain
barrier
low-yield
brain
delivery.
In
addition,
use
high
concentrations
overcome
challenge
may
entail
side
effects.
To
address
these
challenges
enhance
precision
delivery
into
regions
affected
aggregation,
we
proposed
transferrin-conjugated
nanoparticle-based
system.
melittin-loaded
L-arginine-coated
iron
oxide
nanoparticles
(Tf-MeLioNs)
developed
in
study
successfully
mitigated
melittin-induced
cytotoxicity
hemolysis
cell
culture
5XFAD
mouse
brain,
Tf-MeLioNs
remarkably
reduced
plaque
accumulation,
particularly
hippocampus.
This
suggested
Tf-LioNs
potential
platform
candidate
therapeutic
targeting
plaques
AD.
These
findings
provide
foundation
further
exploration
advancement
therapeutics.
Phytomedicine,
Год журнала:
2023,
Номер
114, С. 154762 - 154762
Опубликована: Март 14, 2023
Alzheimer's
disease
(AD)
is
a
neurogenerative
and
remains
no
effective
method
for
stopping
its
progress.
Ferroptosis
adaptive
immunity
have
been
proven
to
contribute
AD
pathogenesis.
Salidroside
exhibits
neuroprotective
immunomodulatory
effects.
However,
the
underlying
mechanisms
linking
salidroside,
ferroptosis,
in
remain
uncertain.The
objective
of
this
study
explore
effects
potential
molecular
salidroside
against
neuronal
ferroptosis
CD8+
T
cell
infiltration
senescence-accelerated
mouse
prone
8
(SAMP8)
mice.SAMP8
mice
were
employed
as
an
model
treated
with
12
weeks.
Behavioral
tests,
immunohistochemistry,
HE
Nissl
staining,
immunofluorescence,
transmission
electron
microscopy,
quantitative
proteomics,
bioinformatic
analysis,
flow
cytometry,
iron
western
blotting,
docking
performed.Treatment
dose-dependently
attenuated
cognitive
impairment,
reduced
accumulation
Aβ
plaques
restored
damage.
also
suppressed
CD8+T
cells,
oxidative
stress,
inflammatory
cytokines,
improved
mitochondrial
metabolism,
lipid
redox
SAMP8
brain.
The
administration
decreased
deposition,
TFR1,
ACSL4
protein
expression,
upregulated
SLC7A11,
GPX4
promoted
Nrf2/GPX4
axis
activation.In
conclusion,
cells
are
involved
process
impairment
mice.
alleviates
inhibits
ferroptosis.
may
involve
activation
reduction
infiltration.
This
provides
some
evidence
roles
Molecular Psychiatry,
Год журнала:
2024,
Номер
29(4), С. 1139 - 1152
Опубликована: Янв. 12, 2024
Iron
is
an
essential
element
for
the
development
and
functionality
of
brain,
anomalies
in
its
distribution
concentration
brain
tissue
have
been
found
to
be
associated
with
most
frequent
neurodegenerative
diseases.
When
magnetic
resonance
techniques
allowed
iron
quantification
vivo,
it
was
confirmed
that
alteration
homeostasis
a
common
feature
many
However,
whether
main
actor
process,
or
consequence
degenerative
process
still
open
question.
Because
different
iron-related
pathogenic
mechanisms
are
specific
distinctive
diseases,
identifying
molecular
various
pathologies
could
represent
way
clarify
this
complex
topic.
Indeed,
both
overload
deficiency
profound
consequences
on
cellular
functioning,
contribute
neuronal
death
processes
manners,
such
as
promoting
oxidative
damage,
loss
membrane
integrity,
proteostasis,
mitochondrial
dysfunction.
In
review,
attempt
elucidate
dyshomeostasis
health,
we
summarize
pathological
couple
death.
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 395 - 395
Опубликована: Март 26, 2024
Central
neurological
disorders
are
significant
contributors
to
morbidity,
mortality,
and
long-term
disability
globally
in
modern
society.
These
encompass
neurodegenerative
diseases,
ischemic
brain
traumatic
injury,
epilepsy,
depression,
more.
The
involved
pathogenesis
is
notably
intricate
diverse.
Ferroptosis
neuroinflammation
play
pivotal
roles
elucidating
the
causes
of
cognitive
impairment
stemming
from
these
diseases.
Given
concurrent
occurrence
ferroptosis
due
metabolic
shifts
such
as
iron
ROS,
well
their
critical
central
nervous
disorders,
investigation
into
co-regulatory
mechanism
has
emerged
a
prominent
area
research.
This
paper
delves
mechanisms
along
with
interrelationship.
It
specifically
emphasizes
core
molecules
within
shared
pathways
governing
neuroinflammation,
including
SIRT1,
Nrf2,
NF-κB,
Cox-2,
iNOS/NO·,
how
different
immune
cells
structures
contribute
dysfunction
through
mechanisms.
Researchers’
findings
suggest
that
mutually
promote
each
other
may
represent
key
factors
progression
disorders.
A
deeper
comprehension
common
pathway
between
cellular
holds
promise
for
improving
symptoms
prognosis
related
Biomolecules,
Год журнала:
2022,
Номер
12(11), С. 1676 - 1676
Опубликована: Ноя. 11, 2022
Damage
or
loss
of
brain
cells
and
impaired
neurochemistry,
neurogenesis,
synaptic
nonsynaptic
plasticity
the
lead
to
dementia
in
neurodegenerative
diseases,
such
as
Alzheimer's
disease
(AD).
Injury
synapses
neurons
accumulation
extracellular
amyloid
plaques
intracellular
neurofibrillary
tangles
are
considered
main
morphological
neuropathological
features
AD.
Age,
genetic
epigenetic
factors,
environmental
stressors,
lifestyle
contribute
risk
AD
onset
progression.
These
factors
associated
with
structural
functional
changes
brain,
leading
cognitive
decline.
Biomarkers
reflect
cause
specific
function,
especially
pathways
neurotransmission,
neuroinflammation,
bioenergetics,
apoptosis,
oxidative
nitrosative
stress.
Even
initial
stages,
is
Aβ
neurotoxicity,
mitochondrial
dysfunction,
tau
neurotoxicity.
The
integrative
amyloid-tau-mitochondrial
hypothesis
assumes
that
primary
neurotoxicity
oligomers
oligomers,
their
mutual
synergy.
For
development
new
efficient
drugs,
targeting
elimination
potentiation
effects,
unwanted
protein
interactions
biomarkers
(mainly
dysfunction)
early
stage
seems
promising.
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
95(3), С. 785 - 803
Опубликована: Авг. 25, 2023
Microglia
and
astrocytes
are
regarded
as
active
participants
in
the
central
nervous
system
under
various
neuropathological
conditions,
including
Alzheimer's
disease
(AD).
Both
microglia
astrocyte
activation
have
been
reported
to
occur
with
a
spatially
temporarily
distinct
pattern.
Acting
double-edged
sword,
glia-mediated
neuroinflammation
may
be
both
detrimental
beneficial
brain.
In
variety
of
neuropathologies,
activated
before
astrocytes,
which
facilitates
activation.
Yet
reactive
can
also
prevent
adjacent
addition
helping
them
become
activated.
Studies
describe
changes
genetic
profile
well
cellular
molecular
responses
these
two
types
glial
cells
that
contribute
dysfunctional
immune
crosstalk
AD.
this
paper,
we
construct
current
knowledge
microglia-astrocyte
communication,
highlighting
multifaceted
functions
their
role
A
thorough
comprehension
communication
could
hasten
creation
novel
AD
treatment
approaches.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12498 - 12498
Опубликована: Авг. 6, 2023
Alzheimer's
disease
(AD)
is
a
chronic
neurodegenerative
disorder
that
accompanied
by
deficits
in
memory
and
cognitive
functions.
The
pathologically
characterised
the
accumulation
aggregation
of
an
extracellular
peptide
referred
to
as
amyloid-β
(Aβ)
form
amyloid
plaques
intracellular
hyperphosphorelated
protein
tau
neurofibrillary
tangles
(NFTs)
cause
neuroinflammation,
synaptic
dysfunction,
oxidative
stress.
search
for
pathomechanisms
leading
onset
progression
has
identified
many
key
players
include
genetic,
epigenetic,
behavioural,
environmental
factors,
which
lend
support
fact
this
multi-faceted
where
failure
various
systems
contributes
progression.
Although
vast
majority
individuals
present
with
sporadic
(non-genetic)
disease,
dysfunctions
numerous
protein-coding
non-coding
genes
have
been
implicated
mechanisms
contributing
disease.
Recent
studies
provided
strong
evidence
association
RNAs
(ncRNAs)
AD.
In
review,
we
highlight
current
findings
on
changes
observed
circular
RNA
(circRNA),
microRNA
(miRNA),
short
interfering
(siRNA),
piwi-interacting
(piRNA),
long
(lncRNA)
Variations
these
ncRNAs
could
potentially
serve
biomarkers
or
therapeutic
targets
diagnosis
treatment
We
also
discuss
results
targeted
cellular
animal
models
AD
view
translating
into
therapies
Biomolecules,
Год журнала:
2023,
Номер
13(2), С. 313 - 313
Опубликована: Фев. 7, 2023
The
deposition
of
amyloid-beta
(Aβ)
plaques
in
the
brain
is
one
primary
pathological
characteristics
Alzheimer’s
disease
(AD).
It
can
take
place
20–30
years
before
onset
clinical
symptoms.
imbalance
between
production
and
clearance
Aβ
major
causes
AD.
Enhancing
at
an
early
stage
attractive
preventive
therapeutic
strategy
Direct
inhibition
aggregation
using
small
molecules,
peptides,
monoclonal
antibody
drugs
has
not
yielded
satisfactory
efficacy
trials
for
decades.
Novel
approaches
are
required
to
understand
combat
deposition.
Neurological
dysfunction
a
complex
process
that
integrates
functions
different
types
cells
brain.
role
non-neurons
AD
been
fully
elucidated.
An
in-depth
understanding
interactions
neurons
contribute
elucidation
formation
identification
effective
drug
targets.
patient-derived
pluripotent
stem
(PSCs)
contain
complete
background
information
have
potential
differentiate
into
various
vitro,
which
may
bring
new
insight
treatment
Here,
we
systematically
review
latest
studies
on
clarify
roles
cell
among
microglia,
astroglia
response
plaques,
will
be
beneficial
explore
methods
reconstructing
models
inducible
PSCs
(iPSCs)
through
differentiation
techniques
validating
applications
plaques.
This
provide
most
promising
directions
finding
clues
preventing
delaying
development
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(2)
Опубликована: Фев. 1, 2024
In
recent
years,
sevoflurane
and
isoflurane
are
the
most
popular
anesthetics
in
general
anesthesia
for
their
safe,
rapid
onset,
well
tolerant.
Nevertheless,
many
studies
reported
neurotoxicity
among
pediatric
aged
populations.
This
effect
is
usually
manifested
as
cognitive
impairment
such
perioperative
neurocognitive
disorders.
The
wide
application
of
during
makes
safety
a
major
health
concern.
Evidence
indicates
that
iron
dyshomeostasis
ferroptosis
may
establish
role
isoflurane.
However,
mechanisms
sevoflurane-
isoflurane-induced
neuronal
injury
were
not
fully
understood,
which
poses
barrier
to
treatment
its
neurotoxicity.
We,
therefore,
reviewed
current
knowledge
on
aimed
promote
better
understanding
roles
