NeuroMolecular Medicine, Год журнала: 2024, Номер 26(1)
Опубликована: Дек. 8, 2024
Язык: Английский
Extracellular Vesicle, Год журнала: 2025, Номер 5, С. 100071 - 100071
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Materials Advances, Год журнала: 2024, Номер 5(10), С. 4025 - 4054
Опубликована: Янв. 1, 2024
Injury and disease in the central nervous system (CNS) can result a dysregulated inflammatory environment that inhibits repair of functional tissue. Biomaterials present promising approach to tackle this complex inhibitory modulate mechanisms involved neuroinflammation halt progression secondary injury promote In review, we will cover recent advances biomaterial strategies, including nanoparticles, hydrogels, implantable scaffolds, neural probe coatings, have been used innate immune response within CNS. The stages inflammation following CNS main contributors common neurodegenerative diseases be discussed, as understanding is critical for identifying therapeutic targets designing effective biomaterial-based treatment strategies. novel composites then discussed with an emphasis on strategies deliver immunomodulatory agents or utilize cell-material interactions tissue repair. We explore application these context nanoparticle- hydrogel-mediated delivery small molecule drugs proteins inflamed tissue, implantation hydrogels scaffolds cell behavior guide axon elongation, coatings mitigate glial scarring enhance signaling at tissue-device interface. Finally, future outlook growing role immunomodulation regenerative medicine neuroengineering applications
Язык: Английский
Процитировано
3
The Neuroscience Journal of Shefaye Khatam, Год журнала: 2024, Номер 12(2), С. 87 - 101
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
3
Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1101 - 1101
Опубликована: Окт. 30, 2024
Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy difficult to prevent control when they develop. It has been known for many years these diseases pathogenic aspects in common. We highlight this review neuroglial cells (astroglia, oligodendroglia, microglia) play a vital role the origin, clinical-pathological development, course brain neurodegeneration. Moreover, we include new results T2D-AD mouse model (APP+PS1 mice on high-calorie diet) investigating.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5697 - 5697
Опубликована: Март 16, 2023
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes that ultimately lead to dementia. Currently, 50 million people worldwide suffer from dementia related AD, the pathogenesis underlying AD pathology cognitive decline unknown. While primarily neurological of brain, individuals with often experience intestinal disorders, gut abnormalities have been implicated as major risk factor in development relevant However, mechanisms mediate injury contribute vicious cycle between brain remain In present study, bioinformatics analysis was performed on proteomics data variously aged mouse colon tissues. We found levels integrin β3 β-galactosidase (β-gal), two markers cellular senescence, increased age colonic tissue mice AD. The advanced artificial intelligence (AI)-based prediction also demonstrated association β-gal phenotypes. Moreover, we showed elevated were accompanied senescence phenotypes immune cell accumulation tissue. Further, genetic downregulation abolished upregulated inflammatory responses epithelial cells conditions associated provide new understanding molecular actions underpinning during suggest may function novel target mediating this disease.
Язык: Английский
Процитировано
8
Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14
Опубликована: Окт. 18, 2022
Non-coding RNAs (ncRNA) are a kind of RNA that does not encode protein, which play an important role in Alzheimer's disease (AD). However, there is lack bibliometric analysis and visualization the research related to AD ncRNAs.Literature ncRNAs last decade were searched through Web Science Core Collection (WOSCC). The relevant information from all articles was collected. website, CiteSpace, VOSviewer used for countries/regions, institutions, authors, keywords.In total, 1,613 kinds literature published field. Literature this field 494 journals. Journal Disease most popular journal. China, Louisiana State University System, Lukiw WJ authors with highest scientific productivity, respectively. hotspots focused on mechanism ncRNAs, especially microRNAs, AD. level mainly based basic research, focusing animal cellular levels, proteomics. "Circular RNAs," "regulation neuroinflammation," "tau protein" future directions.Taken together, developing well. frontiers can provide reference researchers choose their direction.
Язык: Английский
Процитировано
11
Cells, Год журнала: 2024, Номер 13(22), С. 1834 - 1834
Опубликована: Ноя. 6, 2024
Microglia, the resident immune cells of central nervous system (CNS), play a crucial role in maintaining neural homeostasis but can also contribute to disease and injury when this state is disrupted or conversely pivotal neurorepair. One way that microglia exert their effects through secretion small vesicles, microglia-derived exosomes (MGEVs). Exosomes facilitate intercellular communication transported cargoes proteins, lipids, RNA, other bioactive molecules alter behavior internalize them. Under normal physiological conditions, MGEVs are essential homeostasis, whereas dysregulation production and/or alterations have been implicated pathogenesis numerous neurodegenerative diseases, including Alzheimer's (AD), Parkinson's (PD), multiple sclerosis (MS), spinal cord (SCI), traumatic brain (TBI). In contrast, may offer therapeutic potential by reversing inflammation being amenable engineering for delivery beneficial biologics drugs. The determined phenotypic parent microglia. from anti-inflammatory pro-regenerative support neurorepair cell survival delivering neurotrophic factors, mediators, molecular chaperones. Further, deliver components like mitochondrial DNA (mtDNA) proteins damaged neurons enhance cellular metabolism resilience. derived pro-inflammatory detrimental on health. Their cargo often contains cytokines, involved oxidative stress, neurotoxic which exacerbate neuroinflammation, neuronal damage, impair synaptic function, hindering processes. neurodegeneration injury-whether harmful-largely depends how they modulate pro- factors cargo, cytokines microRNAs. addition, propagation pathological such as amyloid-beta alpha-synuclein, progression disorders AD PD, transfer apoptotic necrotic induce neuron toxicity trigger glial scarring during neurological injury. review, we provided comprehensive up-to-date understanding mechanisms underlying multifaceted disease. particular, specific exosome various either recovery, will be discussed. has highlighted methodologies employed cell-selective targeting. Understanding influence balance between signaling CNS developing new strategies diseases neurotrauma.
Язык: Английский
Процитировано
2
Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)
Опубликована: Дек. 6, 2024
Abstract Extracellular vesicles (EVs) are membrane originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced basic biological research to essential clinical significance. capacity selectively enrich specific subsets biofluids via distinctive surface markers opened new avenues for molecular understandings across various tissues and organs, notably In recent years, brain-derived have been extensively investigated as biomarkers, therapeutic targets, drug-delivery vehicles diseases. review provides a brief overview characteristics physiological functions classes EVs, focusing on mechanisms by which types mediate occurrence development Concurrently, novel approaches challenges use delivery delineated.
Язык: Английский
Процитировано
2
Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15
Опубликована: Март 9, 2023
Alzheimer's disease (AD) is the most common neurodegenerative in elderly people. Many researches have reported that neuroinflammation related to AD. Chemokines are a class of small cytokines play important roles cell migration and communication, which involved neuroinflammation. Up now there no meta-analysis explore difference chemokines between AD patients healthy individuals.We searched PubMed, Web science, Cochrane library, EMBASE Scopus databases from inception January 2022. Data were extracted by two independent reviewers, Review Manager 5.3 was used for meta-analysis.Thirty-two articles included analyzed. The total number participants study 3,331. We found levels CCL5 (SMD = 2.56, 95% CI: 1.91-3.21), CCL15 3.30, 1.48-5.13) IP-10 3.88, 1.84-5.91) plasma higher than MCP-1 protein 0.67, 0.29-1.05) patients' CSF controls.These results suggested may an role These findings could provide evidences diagnosis treatment AD.https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021278736, identifier: CRD42021278736.
Язык: Английский
Процитировано
6
Materials Today Bio, Год журнала: 2023, Номер 22, С. 100789 - 100789
Опубликована: Сен. 1, 2023
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which not just confined to the older population. Although developments have been made in AD treatment, various limitations remain be addressed. These are partly contributed by biological hurdles, such as blood–brain barrier and peripheral side effects, well lack of carriers that can efficiently deliver therapeutics brain while preserving their therapeutic efficacy. The increasing prevalence unavailability effective treatments encouraged researchers develop improved, convenient, affordable therapies. Functional materials based on primitive cells nanotechnology emerging attractive treatment. Cell primitives possess distinct functions, including long-term circulation, lesion site targeting, immune suppression. This review summarizes challenges delivery drugs recent advances cell primitive–based for Various primitives, cells, extracellular vesicles, membranes, presented together with distinctive functions construction strategies. Moreover, future research directions discussed basis foreseeable perspectives.
Язык: Английский
Процитировано
6