Abstract
Gray
matter
(GM)
alterations
play
a
role
in
aging‐related
disorders
like
Alzheimer's
disease
and
related
dementias,
yet
MRI
studies
mainly
focus
on
macroscopic
changes.
Although
reliable
indicators
of
atrophy,
morphological
metrics
cortical
thickness
lack
the
sensitivity
to
detect
early
changes
preceding
visible
atrophy.
Our
study
aimed
at
exploring
potential
diffusion
unveiling
sensitive
markers
subcortical
age‐related
microstructural
assessing
their
associations
with
cognitive
behavioral
deficits.
We
leveraged
Human
Connectome
Project‐Aging
cohort
that
included
707
participants
(394
female;
median
age
=
58,
range
36–90
years)
applied
powerful
mean
apparent
propagator
model
measure
parameters,
along
comprehensive
test
scores.
Both
macro‐
GM
characteristics
were
strongly
associated
age,
widespread
significant
correlations
reflective
cellular
changes,
reduced
density,
increased
extracellular
volume,
membrane
permeability.
Importantly,
when
correlating
scores,
our
findings
revealed
no
link
between
macrostructural
volumetric
neurobehavioral
performance.
However,
we
found
regions
Based
these
findings,
it
is
hypothesized
heterogeneity
decreased
neurite
orientation
dispersion
precede
they
an
important
subsequent
decline.
These
are
suggested
be
neurocognitive
performance
may
distinctly
aid
identifying
mechanisms
underlying
phenotypic
aging
functional
The
increasing
prevalence
of
depression
among
older
adults
is
a
growing
concern.
Chronic
health
conditions,
cognitive
impairments,
and
hospitalizations
amplify
emotional
distress
levels
in
this
population.
Assessing
the
quality
life
crucial
for
well-being
adults.
Our
study
aimed
to
examine
how
comorbidities
affect
geriatric
patients
both
outpatient
hospital
settings.
100
(50
from
internal
medicine
clinic
50
ward)
were
included
according
inclusion
exclusion
criteria.
Patients
classified
into
different
age
groups
(65–74
years,
75–84
years
≥
85
years).
Data
on
patients'
location
application,
age,
sex,
living
alone
or
with
family
status,
number
comorbid
diseases,
types
accompanying
diseases
recorded
WHOQOL-OLD
Geriatric
Depression
Scale
(GDS)
questionnaires
administered.
Results
evaluated
using
SPSS.
questionnaire
score
was
higher
65–74
group
compared
other
groups,
but
there
no
significant
difference
between
hospitalized
group.
had
lower
scores
those
without
diseases.
In
GDS
group,
than
ones
findings
indicate
that
aged
65–74,
incidence
groups.
Hospitalization
correlates
rates
not
life.
As
increases
adults,
frequency
rises
declines.
Early
detection
intervention
are
enhancing
adults'
well-being.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10535 - 10535
Опубликована: Сен. 30, 2024
Progress
made
by
the
medical
community
in
increasing
lifespans
comes
with
costs
of
incidence
and
prevalence
age-related
diseases,
neurodegenerative
ones
included.
Aging
is
associated
a
series
morphological
changes
at
tissue
cellular
levels
brain,
as
well
impairments
signaling
pathways
gene
transcription,
which
lead
to
synaptic
dysfunction
cognitive
decline.
Although
we
are
not
able
pinpoint
exact
differences
between
healthy
aging
neurodegeneration,
research
increasingly
highlights
involvement
neuroinflammation
chronic
systemic
inflammation
(inflammaging)
development
age-associated
via
pathogenic
cascades,
triggered
dysfunctions
circadian
clock,
gut
dysbiosis,
immunosenescence,
or
impaired
cholinergic
signaling.
In
addition,
gender
susceptibility
course
neurodegeneration
that
appear
be
mediated
glial
cells
emphasize
need
for
future
this
area
an
individualized
therapeutic
approach.
rejuvenation
still
its
very
early
infancy,
accumulated
knowledge
on
various
involved
promoting
senescence
opens
perspective
interfering
these
preventing
delaying
senescence.
Antioxidants,
Год журнала:
2024,
Номер
13(2), С. 206 - 206
Опубликована: Фев. 6, 2024
The
brain
has
a
high
metabolism
rate
that
may
generate
reactive
oxygen
and
nitrogen
species.
Consequently,
nerve
cells
require
highly
efficient
antioxidant
defenses
in
order
to
prevent
condition
of
deleterious
oxidative
stress.
This
is
particularly
relevant
the
hippocampus,
complex
cerebral
area
involved
processing
superior
cognitive
functions.
Most
current
evidence
points
hippocampal
damage
as
causal
effect
for
neurodegenerative
disorders,
especially
Alzheimer's
disease.
Nuclear
factor
erythroid-2-related
2/Kelch-like
ECH-associated
protein
1
(Nrf2/Keap1)
master
key
transcriptional
regulation
detoxifying
systems.
It
ubiquitously
expressed
areas,
mainly
supporting
glial
cells.
In
present
study,
we
have
analyzed
relationships
between
Nrf2
Keap1
isoforms
tissue
response
aging
dietary
long-chain
polyunsaturated
fatty
acids
(LCPUFA)
supplementation.
possible
involvement
lipoxidative
nitrosative
by-products
dynamics
Nrf2/Keap1
was
examined
though
determination
adducts,
namely
malondialdehyde
(MDA),
4-hydroxynonenal
(HNE),
3-nitro-tyrosine
(NTyr)
under
basal
conditions.
results
were
correlated
expression
target
proteins
heme-oxygenase-1
(HO-1)
glutathione
peroxidase
4
(GPx4),
whose
expressions
are
known
be
regulated
by
signaling
activation.
All
variables
this
study
obtained
simultaneously
from
same
preparations,
allowing
multivariate
approaches.
demonstrate
modification
patterns
together
with
formation
adducts
diet
Both
parameters
exhibited
strong
interaction.
Noticeably,
LCPUFA
supplementation
aged
animals
restored
Nrf2/Keap1/target
status
observed
young
animals,
therefore
driving
"rejuvenation"
defense.
Bioengineering,
Год журнала:
2024,
Номер
11(5), С. 418 - 418
Опубликована: Апрель 24, 2024
The
study
of
the
effects
aging
on
neural
activity
in
human
brain
has
attracted
considerable
attention
neurophysiological,
neuropsychiatric,
and
neurocognitive
research,
as
it
is
directly
linked
to
an
understanding
mechanisms
underlying
disruption
structures
functions
that
lead
age-related
pathological
disorders.
Electroencephalographic
(EEG)
signals
recorded
during
resting-state
conditions
have
been
widely
used
because
significant
advantage
non-invasive
signal
acquisition
with
higher
temporal
resolution.
These
advantages
include
capability
a
variety
linear
nonlinear
analyses
state-of-the-art
machine-learning
deep-learning
techniques.
Advances
artificial
intelligence
(AI)
can
not
only
reveal
but
also
enable
assessment
age
reliably
by
means
characteristics
EEG
signals.
This
paper
reviews
literature
features,
available
analytic
methods,
large-scale
databases,
interpretations
resulting
findings,
recent
advances
AI
models.
Abstract
Gray
matter
(GM)
alterations
play
a
role
in
aging‐related
disorders
like
Alzheimer's
disease
and
related
dementias,
yet
MRI
studies
mainly
focus
on
macroscopic
changes.
Although
reliable
indicators
of
atrophy,
morphological
metrics
cortical
thickness
lack
the
sensitivity
to
detect
early
changes
preceding
visible
atrophy.
Our
study
aimed
at
exploring
potential
diffusion
unveiling
sensitive
markers
subcortical
age‐related
microstructural
assessing
their
associations
with
cognitive
behavioral
deficits.
We
leveraged
Human
Connectome
Project‐Aging
cohort
that
included
707
participants
(394
female;
median
age
=
58,
range
36–90
years)
applied
powerful
mean
apparent
propagator
model
measure
parameters,
along
comprehensive
test
scores.
Both
macro‐
GM
characteristics
were
strongly
associated
age,
widespread
significant
correlations
reflective
cellular
changes,
reduced
density,
increased
extracellular
volume,
membrane
permeability.
Importantly,
when
correlating
scores,
our
findings
revealed
no
link
between
macrostructural
volumetric
neurobehavioral
performance.
However,
we
found
regions
Based
these
findings,
it
is
hypothesized
heterogeneity
decreased
neurite
orientation
dispersion
precede
they
an
important
subsequent
decline.
These
are
suggested
be
neurocognitive
performance
may
distinctly
aid
identifying
mechanisms
underlying
phenotypic
aging
functional
