Stromal cells regulate mechanics of tumour spheroid DOI Creative Commons
Ayushi Agrawal,

Soufian Lasli,

Yousef Javanmardi

и другие.

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100821 - 100821

Опубликована: Окт. 6, 2023

The remarkable contractility and force generation ability exhibited by cancer cells empower them to overcome the resistance steric hindrance presented a three-dimensional, interconnected matrix. Cancer disseminate actively remodelling deforming their extracellular matrix (ECM). process of tumour growth its ECM have been extensively studied, but effect cellular microenvironment (TME) has ignored in most studies that investigated tumour-cell-mediated deformations realignment. This study reports integration stromal spheroid assays impacts invasion abilities spheroids. To investigate this, we developed novel multilayer vitro assay incorporates quantifies contractile spheroids exert on ECM. We observed negative correlation between potential levels collagen deformation. presence significantly increased cell invasiveness altered cells' deform realign gel, due upregulation proinflammatory cytokines. Interestingly, this was consistently both metastatic non-metastatic cells. Our findings contribute better understanding vital role played TME regulating invasive outgrowth underscore utilising deformation measurements as biophysical marker for evaluating informing targeted therapeutic opportunities.

Язык: Английский

Innovations in aging biology: highlights from the ARDD emerging science & technologies workshop DOI Creative Commons
Maximilian Unfried, Tomas Schmauck‐Medina, Neal D. Amin

и другие.

npj Aging, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 18, 2025

The field of biogerontology has established itself through significant lines research in recent decades. However, despite early breakthroughs, progress understanding the aging process been slow. To push forward, new methodologies and technologies are likely needed to unravel complexity aging. This meeting brought together leading scientists innovators explore some emerging approaches, presenting groundbreaking advancements four key sessions, culminating a panel discussion.

Язык: Английский

Процитировано

0
Stromal cells regulate mechanics of tumour spheroid DOI Creative Commons
Ayushi Agrawal,

Soufian Lasli,

Yousef Javanmardi

и другие.

Materials Today Bio, Год журнала: 2023, Номер 23, С. 100821 - 100821

Опубликована: Окт. 6, 2023

The remarkable contractility and force generation ability exhibited by cancer cells empower them to overcome the resistance steric hindrance presented a three-dimensional, interconnected matrix. Cancer disseminate actively remodelling deforming their extracellular matrix (ECM). process of tumour growth its ECM have been extensively studied, but effect cellular microenvironment (TME) has ignored in most studies that investigated tumour-cell-mediated deformations realignment. This study reports integration stromal spheroid assays impacts invasion abilities spheroids. To investigate this, we developed novel multilayer vitro assay incorporates quantifies contractile spheroids exert on ECM. We observed negative correlation between potential levels collagen deformation. presence significantly increased cell invasiveness altered cells' deform realign gel, due upregulation proinflammatory cytokines. Interestingly, this was consistently both metastatic non-metastatic cells. Our findings contribute better understanding vital role played TME regulating invasive outgrowth underscore utilising deformation measurements as biophysical marker for evaluating informing targeted therapeutic opportunities.

Язык: Английский

Процитировано

7