Life,
Год журнала:
2024,
Номер
14(5), С. 597 - 597
Опубликована: Май 7, 2024
Neurodegenerative
diseases
such
as
dementia
and
Parkinson’s
disease
pose
significant
challenges
to
older
adults
globally.
While
pharmacological
treatments
remain
primary,
increasing
evidence
supports
the
role
of
non-pharmacological
strategies
like
physical
activity
in
managing
these
conditions.
This
systematic
review
critically
evaluates
effectiveness
Nursing
based
interventions
improving
cognitive
function,
functioning,
mobility,
overall
quality
life
among
with
neurodegenerative
diseases.
We
conducted
a
comprehensive
search
across
PubMed,
EMBASE,
Web
Science,
CENTRAL,
other
relevant
databases,
focusing
on
randomized
controlled
trials
observational
studies
that
examined
impact
structured
activity.
Our
findings
from
nineteen
involving
1673
participants
indicate
ranging
aerobic
exercises,
resistance
training,
mind-body
exercises
Tai
Chi
yoga
have
beneficial
effects.
Specifically,
was
consistently
found
enhance
performance,
increase
improve
balance
daily
living
activities,
contributing
better
life.
However,
benefits
vary
depending
type,
intensity,
duration
performed.
Despite
promising
results,
limitations
small
sample
sizes,
study
heterogeneity,
short-term
follow-up
periods
call
for
more
robust,
long-term
solidify
findings.
underscores
potential
tailored
programs
adjunctive
therapy
management
elderly
population.
Neurological Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Янв. 4, 2025
Objectives
The
aim
of
this
study
was
to
investigate
the
effect
eight
weeks
aerobic
training
(AT)
and
vitamin
C
supplementation
(VC)
on
apoptotic
markers
in
hippocampus
tissue
AD
rats
treated
with
trimethyltin
(TMT).
Brazilian Journal of Health Review,
Год журнала:
2025,
Номер
8(1), С. e76714 - e76714
Опубликована: Янв. 10, 2025
A
doença
de
Alzheimer
(DA)
é
a
etiologia
mais
comum
entre
as
demências,
correspondendo
60%
dos
quadros
demenciais
e
tende
se
intensificar
com
o
envelhecimento
populacional.
prática
exercício
físico
proporciona
efeitos
benéficos
um
grande
número
agravos
relacionados
à
DA.
Além
disso,
tem
anti-inflamatórios
antioxidantes
menos
colaterais
do
que
os
medicamentos.
Muitos
estudos
recomendam
seu
uso
no
tratamento
da
DA,
dada
crescente
evidência
para
apoiar
seus
positivos
na
saúde
mental,
doenças
neurodegenerativas
demências.
No
entanto,
profissionais
movimento
precisam
estar
atualizados
sobre
estratégias
treinamento
efetivas
eficazes
essa
população.
Dessa
forma,
objetivo
desse
estudo
revisão
foi
refletir,
baseado
em
evidências
científicas,
das
principais
(aeróbio,
resistido
multicomponente)
pessoas
portadoras
Entre
apresentadas,
multicomponente
apresentou
maior
respaldo
literatura
melhora
aspectos
relacionado
além
qualidade
vida
depressão,
sendo
institucionalizadas
ou
não.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 8, 2025
Neurogenesis
is
an
active
process
of
creating
new
neurons
in
the
neurogenic
zone.
It
influenced
by
many
factors,
including
circadian
system,
which
synchronized
light.
laboratory
rodents
peaks
at
night,
and
are
nocturnal,
contrary
to
humans
that
during
day.
Here,
we
studied
whether
proliferation
apoptosis
exhibit
a
daily
rhythm
brain
diurnal
songbird
zebra
finch
(Taeniopygia
guttata)
cell
dark
phase
day,
as
rodents.
We
injected
birds
with
marker
5-ethynyl-2´-deoxyuridine
(EdU;
thymidine
analog),
quantified
number
dividing
cells
ventricular
zone
(VZ),
measured
mRNA
expression
clock
genes
well
indicating
or
apoptosis.
First,
confirmed
rhythms
genes.
Next
found
along
whole
VZ
did
not
rhythm.
However,
central
ventral
part
VZ,
i.e.
"the
hot-spot"
area,
showed
proliferation.
The
highest
newborn
was
detected
relative
apoptotic
caspase
3,
Bcl-2,
Bax
proliferating
nuclear
antigen
(PCNA)
show
any
In
summary,
our
results
"hot-spot"
region
songbirds
shows
rhythmic
activity
over
period
24
h
maximum
occurs
passive
phase.
This
study
may
have
implications
for
understanding
mechanisms
underlying
regulation
different
species.
Zabajkalʹskij medicinskij vestnik,
Год журнала:
2025,
Номер
4, С. 126 - 132
Опубликована: Фев. 25, 2025
Over
the
past
couple
of
decades,
it
has
become
apparent
that
skeletal
muscles
work
as
an
endocrine
organ
can
produce
and
secrete
myokines
exert
their
effects
in
endocrine,
paracrine,
or
autocrine
manner.
Modern
research
shows
physical
exertion
induces
synthesis
molecules
involved
transmission
signals
between
muscle
cells
other
organs,
particular
brain,
adipose
tissue,
organs
gastrointestinal
tract,
well
skin
vascular
cells.
This
review
examines
cause
communication
with
neuroprotection
response
to
activity
related
processes.
Unlike
exercise-induced
protective
signaling
pathways,
inactivity
wasting
disrupt
expression
secretion
and,
turn,
function
central
nervous
system.
It
is
assumed
adapting
from
brain
by
modulating
will
help
combat
age-related
neurodegeneration
diseases
affected
systemic
signals.
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Alzheimer's
disease
(AD)
is
the
leading
cause
of
morbidity
and
mortality
worldwide,
as
a
result
cognitive
decline
neurological
dysfunction.
In
AD,
reduced
cerebral
blood
flow
impaired
vascularization
from
capillary
bed
degeneration
decreased
angiogenesis,
observed
in
both
patients
animal
models.
Physical
exercise
recognized
potential
intervention
to
delay
AD
progression
reduce
risk.
While
most
studies
have
focused
on
benefits
aerobic
(AE),
emerging
evidence
suggests
that
resistance
(RE)
also
exerts
positive
effects
overall
health
function
aging
AD.
However,
notable
gap
knowledge
remains
regarding
RE
vascular
structure.
This
review
explores
processes
by
which
AE
influence
brain
including
flow,
endothelial
function,
angiogenesis
neurotrophic
factor
levels.
Based
pre-clinical
clinical
studies,
we
conclude
contribute
improved
promoting
repair
AD-affected
brain.
By
examining
relationship
between
modalities
vascularization,
this
expands
underlying
neuroprotective
neurodegenerative
conditions.
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 3, 2025
Background
Alzheimer’s
disease
(AD)
is
the
most
common
form
of
dementia
globally,
placing
a
substantial
economic
burden
on
patients
and
society.
Exercise
serves
as
an
adjuvant
therapy
for
AD
with
low
incidence
related
adverse
events.
As
non-pharmacological
intervention,
it
has
demonstrated
significant
potential
in
AD.
Objective
This
study
examines
key
hotspots
emerging
trends
exercise
AD,
offering
valuable
insights
researchers
engaged
future
research
this
field.
Methods
The
Web
Science
Core
Collection
database
was
utilized
to
search
literature
from
January
1,
2000,
November
2024,
1,372
relevant
articles
being
identified.
And
CiteSpace
6.2.R4
VOSviewer
were
used
evaluate
bibliometric
indicators.
Results
Since
number
publications
field
been
increasing.
In
addition
well-known
areas
research,
such
impact
cognitive
function,
combination
medication
therapy,
effects
specific
symptoms,
music
may
also
focus
more
novel
topics.
These
include
integration
design
implementation
interventions,
dendritic
spines,
neurophysiological
mechanisms.
Furthermore,
analysis
keywords
reveals
that
current
main
direction
exploring
physiological
mechanisms
through
which
affects
includes
three
trends:
impairment
patients,
brain-derived
neurotrophic
factor
(BDNF)
Amyloid
beta,
influence
Stress
neuroinflammation.
Conclusion
results
indicate
interventions
using
alleviate
negative
symptoms
well
combining
are
gaining
increasing
attention
researchers.
Meanwhile,
topics
should
attract
scholarly
interest.
Additionally,
behind
could
be
research.
PLoS ONE,
Год журнала:
2025,
Номер
20(4), С. e0321304 - e0321304
Опубликована: Апрель 3, 2025
Objectives
The
present
study
aims
to
investigate
the
role
that
cognitive
cerebellar
lobules,
compared
motor
ones,
could
have
on
performance
abilities
control
in
older
individuals
with
Mild
Cognitive
Impairment
(MCI).
Methods
Thirty-six
participants
MCI
were
retrospectively
recruited
from
outpatient
clinic
for
Decline
and
Dementia
at
Geriatric
Clinic
Regional
Center
Brain
Aging.
Cognition
was
assessed
through
a
reaction
time
(RT)
task
which
mere
(COG)
component
(RT/S1
COG,
RT/S3
COG)
has
been
isolated
(MOT)
MOT,
MOT).
Performance
evaluated
using
Short
Physical
Battery
(SPPB),
Tinetti
Scale,
Activities
of
Daily
Living
(ADL).
Finally,
structural
neuroimaging
conducted
magnetic
resonance
imaging
3T.
Results
Left_Crus_I
showed
correlation
SPPB,
ADL%,
COG.
Vermis_VI
Right_VI
correlated
COG
entire
lobule
VI.
ADL%
negative
correlations
RT/S1
MOT.
In
regression
analysis,
strongest
associations
found
between
SPPB
gait
speed
(R
2
=
0.44,
p
0.03),
0.62,
<
0.001),
0.78,
0.001).
Regarding
volumes,
Right_Crus_I
associated
all
tests,
while
Left_VI
functional
autonomy
(ADL%:
R
0.04).
No
variables
total
intracranial
volume.
Conclusions
This
highlights
dominates
over
one
even
physical
capabilities
adults
MCI.
