A Mathematical Study of Effects of Alzheimer’s Drug Donepezil Hydrochloride on Neuronal Viscoelasticity and Action Potentials DOI Creative Commons
Corina S. Drapaca

Mathematical and Computational Applications, Год журнала: 2024, Номер 29(6), С. 117 - 117

Опубликована: Дек. 12, 2024

Alzheimer’s disease (AD) is a degenerative disorder characterized by progressive cognitive decline and memory loss. The few contemporary therapies may ease symptoms and/or slow down AD progression but cannot cure the disease. orally administered drug donepezil hydrochloride enhances availability of acetylcholine that supports cholinergic neurotransmission. In this paper, generalized Hodgkin-Huxley model proposed uses Caputo fractional order temporal derivatives to link action potentials viscoelasticity receptors. provides not only structurally dependent for health also possible mechanism effect on potentials: binding between receptors preserves structural fitness these addition, pharmacokinetic transport brain incorporates controlled release modalities. are used again anomalous release. Numerical simulations show how recovers integrity which further brings abnormal due their healthy state. results suggest combining various modalities dosages improve treatment effectiveness with donepezil.

Язык: Английский

Loss of Cholinergic and Monoaminergic Afferents in APPswe/PS1ΔE9 Transgenic Mouse Model of Cerebral Amyloidosis Preferentially Occurs Near Amyloid Plaques DOI Open Access
Michael K. Lee, Gang Chen

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 5004 - 5004

Опубликована: Май 3, 2024

Alzheimer’s disease (AD) is characterized by a loss of neurons in the cortex and subcortical regions. Previously, we showed that progressive degeneration monoaminergic (MAergic) seen human AD recapitulated APPswe/PS1ΔE9 (APP/PS) transgenic mouse model. Because cholinergic (Ach) also prominent feature AD, examined integrity Ach system APP/PS The overall density fibers reduced APP/PS1 mice at 12 18 months age but not 4 age. Analysis basal forebrain shows no Thus, since MAergic systems show overt cell age, less vulnerable to neurodegeneration We whether proximity Aβ deposition affected 5-HT afferents. found areas closer edges compact deposits exhibit more severe afferents than are distal deposits. Collectively, results indicate model recapitulates multiple neurotransmitter systems, including system. In addition, cause global as well local toxicity

Язык: Английский

Процитировано

2
Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel disease DOI Creative Commons
Qin Li, Shu Su, Yuxue Feng

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(7), С. 4891 - 4902

Опубликована: Июнь 19, 2024

Long-term blood pressure variability (BPV) and plasma neurofilament light (pNfL) have been identified as potential biomarkers for Alzheimer's disease (AD) cerebral small vessel (CSVD). However, the relationship between BPV, pNfL, their association with comorbidity of AD CSVD remains unknown.

Язык: Английский

Процитировано

1
Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: an update of the literature DOI

Tina Milos,

Barbara Vuić,

N. Balic

и другие.

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Сен. 4, 2024

The importance of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) diagnosis is rapidly increasing, and there a growing interest the use CSF monitoring response to therapy, especially light newly available approaches therapy neurodegenerative diseases.

Язык: Английский

Процитировано

1
From Organotypic Mouse Brain Slices to Human Alzheimer’s Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth DOI Creative Commons
Necat Yιlmaz, Katharina Steiner,

Josef Marksteiner

и другие.

Biomolecules, Год журнала: 2024, Номер 14(10), С. 1326 - 1326

Опубликована: Окт. 18, 2024

Alzheimer's disease (AD) is a neurodegenerative characterized by memory loss and progressive deterioration of cognitive functions. Being able to identify reliable biomarkers in easily available body fluids such as blood plasma vital for the disease. To achieve this, we used technique that applied human organotypic brain slice culture via microcontact printing. After 2-week period, performed immunolabeling neurofilament myelin oligodendrocyte glycoprotein (MOG) visualize newly formed nerve fibers oligodendrocytes. There was no significant change number new AD group compared healthy control group, while length produced significantly decreased. A increase MOG+ dots around these detected patient group. According our hypothesis, there are factors patients affect growth fibers, which also Based on findings, selected most promising samples conducted mass spectrometry using differential approach identified three putative biomarkers: aldehyde-dehydrogenase 1A1, alpha-synuclein protein S100-A4. Our method represents novel innovative translating research findings from mouse models applications.

Язык: Английский

Процитировано

1
Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer’s disease DOI Creative Commons
Siva Sundara Kumar Durairajan,

Karthikeyan Selvarasu,

Abhay Singh

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 23, 2024

Alzheimer’s disease (AD) is marked by the gradual and age-related deterioration of nerve cells in central nervous system. The histopathological features observed brain affected AD are aberrant buildup extracellular intracellular amyloid-β formation neurofibrillary tangles consisting hyperphosphorylated tau protein. Axonal transport a fundamental process for cargo movement along axons relies on molecular motors like kinesins dyneins. Kinesin’s responsibility transporting crucial within neurons implicates its dysfunction impaired axonal AD. Impaired motor proteins, with dysregulated signaling pathways, contribute significantly to synaptic impairment cognitive decline Dysregulation tau, microtubule-associated protein, emerges as player, destabilizing microtubules disrupting kinesin-1. Kinesin-1 superfamily members, including kinesin family members 5A, 5B, 5C, light chain, intricately linked pathology. However, inconsistencies abundance patients underline necessity further exploration into mechanistic impact these proteins neurodegeneration disruptions across spectrum neurological conditions. This review underscores significance kinesin-1’s anterograde It emphasizes need investigations underlying mechanisms protein various Despite current limitations scientific literature, our study advocates targeting autophagy dysfunctions promising avenues novel therapeutic interventions diagnostics

Язык: Английский

Процитировано

1
Association of hemoglobin with plasma neurofilament light and white matter hyperintensities in Alzheimer’s disease continuum DOI Creative Commons
Qin Li,

Jiehong Zhan,

Zixuan Liao

и другие.

Heliyon, Год журнала: 2024, Номер unknown, С. e37507 - e37507

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
A multifactorial lens on risk factors promoting the progression of Alzheimer’s disease DOI

Jenna Parker,

Jose M. Moris, Lily C. Goodman

и другие.

Brain Research, Год журнала: 2024, Номер 1846, С. 149262 - 149262

Опубликована: Окт. 5, 2024

Язык: Английский

Процитировано

0
A Mathematical Study of Effects of Alzheimer’s Drug Donepezil Hydrochloride on Neuronal Viscoelasticity and Action Potentials DOI Creative Commons
Corina S. Drapaca

Mathematical and Computational Applications, Год журнала: 2024, Номер 29(6), С. 117 - 117

Опубликована: Дек. 12, 2024

Alzheimer’s disease (AD) is a degenerative disorder characterized by progressive cognitive decline and memory loss. The few contemporary therapies may ease symptoms and/or slow down AD progression but cannot cure the disease. orally administered drug donepezil hydrochloride enhances availability of acetylcholine that supports cholinergic neurotransmission. In this paper, generalized Hodgkin-Huxley model proposed uses Caputo fractional order temporal derivatives to link action potentials viscoelasticity receptors. provides not only structurally dependent for health also possible mechanism effect on potentials: binding between receptors preserves structural fitness these addition, pharmacokinetic transport brain incorporates controlled release modalities. are used again anomalous release. Numerical simulations show how recovers integrity which further brings abnormal due their healthy state. results suggest combining various modalities dosages improve treatment effectiveness with donepezil.

Язык: Английский

Процитировано

0