Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Regular
exercise
enhances
life
quality,
lowers
the
risk
of
cognitive
damage,
and
slows
advancement
Alzheimer's
disease
(AD).
Natural
compounds
rich
in
polyphenols
have
garnered
attention
as
a
non-pharmacological
means
treating
preventing
AD.
The
primary
component
wine,
grape
seeds,
nuts
is
polyphenols.
Research
suggests
that
slow
down
rate
neurodegeneration
AD
lessen
learning
impairment.
Furthermore,
brain
impairments
related
to
cognition.
Additionally,
can
specifically
restructure
amyloid-β
(Aβ)
structures
soluble
oligomers
into
non-toxic
alternative
species.
They
also
been
revealed
increase
brain-derived
neurotrophic
factors
expression,
suggesting
they
positive
impact
on
creation
neurotrophins.
benefits
polyphenol
supplementation
exercise,
which
both
provide
neuroprotection,
not
well
studied
patients.
This
review
aimed
investigate
effects
combined
inflammation,
several
conformational
toxic
species
Aβ,
Aβ-induced
apoptosis
Nutrients,
Год журнала:
2024,
Номер
16(20), С. 3431 - 3431
Опубликована: Окт. 10, 2024
Background:
The
aging
population
is
associated
with
a
net
increase
in
the
incidence
and
prevalence
of
chronic-degenerative
diseases,
particularly
neurocognitive
disorders.
Therefore,
identification
preventative
strategies
to
restrain
burden
such
chronic
conditions
key
relevance.
Red
wine
its
components
have
accumulated
evidence
regarding
their
positive
effects
terms
neurological
pathologies
symptoms.
Methods:
Based
on
this
background,
present
narrative
review
aims
summarize
state-of-the-art
red
disorders
both
preclinical
clinical
settings.
Results:
main
findings
highlight
protective
effect
polyphenols
dementia
different
models
cognitive
decline.
current
translational
remains
uncertain,
especially
considering
risk-to-benefit
ratio
alcohol
consumption
brain
health.
Conclusions:
Given
overall
health
risks
consistent
prevailing
guidelines
literature,
there
insufficient
support
light-to-moderate
as
an
effective
strategy
for
preventing
these
diseases.
However,
largely
derived
from
remain
significant
interest
context.
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Regular
exercise
enhances
life
quality,
lowers
the
risk
of
cognitive
damage,
and
slows
advancement
Alzheimer's
disease
(AD).
Natural
compounds
rich
in
polyphenols
have
garnered
attention
as
a
non-pharmacological
means
treating
preventing
AD.
The
primary
component
wine,
grape
seeds,
nuts
is
polyphenols.
Research
suggests
that
slow
down
rate
neurodegeneration
AD
lessen
learning
impairment.
Furthermore,
brain
impairments
related
to
cognition.
Additionally,
can
specifically
restructure
amyloid-β
(Aβ)
structures
soluble
oligomers
into
non-toxic
alternative
species.
They
also
been
revealed
increase
brain-derived
neurotrophic
factors
expression,
suggesting
they
positive
impact
on
creation
neurotrophins.
benefits
polyphenol
supplementation
exercise,
which
both
provide
neuroprotection,
not
well
studied
patients.
This
review
aimed
investigate
effects
combined
inflammation,
several
conformational
toxic
species
Aβ,
Aβ-induced
apoptosis
