Anti-Amyloid Agents: A Self-Fulfilling prophecy

Journal of Clinical Neuroscience, Год журнала: 2025, Номер 137, С. 111338 - 111338

Опубликована: Май 19, 2025

Язык: Английский

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β-Hydroxybutyrate and melatonin suppress maladaptive UPR, excessive autophagy and pyroptosis in Aβ 1–42 and LPS-Induced SH-SY5Y cells

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Июль 13, 2024

Язык: Английский

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The autophagy paradox: A new hypothesis in neurodegenerative disorders

Neurochemistry International, Год журнала: 2024, Номер 179, С. 105827 - 105827

Опубликована: Авг. 5, 2024

Язык: Английский

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Evaluating Combined Neurotoxicity of Amyloid Beta and Tau Oligomers in Alzheimer's Disease: A New Criterion

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 3, 2024

Abstract A criterion characterizing the combined neurotoxicity of amyloid beta and tau oligomers is suggested. mathematical model that makes it possible to calculate a value this during senile plaque NFT formation proposed. Computations show for physiologically relevant parameter values, increases approximately linearly as time increases. Once neurofibrillary tangles starts in addition formation, slope rate at which becomes larger. The critical upon reaching neuron dies estimated. predict unless production rates monomers are very large, order accumulated toxicity reach value, degradation machinery responsible must become dysfunctional. after 20 years aggregation process strongly influenced by deposition into plaques NFTs. This suggests NFTs may reduce sequestering more toxic oligomeric species less insoluble aggregates.

Язык: Английский

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Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy

Journal of Zhejiang University SCIENCE B, Год журнала: 2024, Номер 25(6), С. 485 - 498

Опубликована: Май 15, 2024

Язык: Английский

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