DELVE INTO THE SYNTHESIS AND CHEMISTRY OF PHYTOCANNABINOIDS, EMPHASIZING THEIR POTENTIAL AS THERAPEUTIC ALTERNATIVES FOR NEUROPSYCHOLOGICAL DISORDERS, INCLUDING ALZHEIMER DOI Creative Commons

Sudhair Abbas Bangash,

Bilal tayab,

Mr. Hassan Saleemi

и другие.

Опубликована: Фев. 29, 2024

Introduction: Alzheimer's disease, a progressive neurodegenerative condition, induces memory loss and cognitive impairments, posing significant challenges for patients, families, caregivers. Cannabidiol (CBD), derived from cannabis, exhibits neuroprotective properties influences cognition behavior. Its therapeutic potential in treatment is increasingly recognized, aiming to alleviate symptoms improve patient outcomes. Objectives: This study aims conduct an integrative review of cannabinoids' effects, particularly CBD, treating disease. Methods: An literature was conducted explore the impact cannabis-based treatments on patients. Key health science databases such as LILACS, PubMed, Scopus, Web Science, Google Scholar were systematically searched using relevant descriptors (e.g., Cannabidiol, Tetrahydrocannabinol, Alzheimer's, Treatment). Results: Forty studies identified selected databases, with 37 meeting eligibility criteria inclusion this review. Discussion: CBD emerges complementary option managing neurological Tetrahydrocannabinol (THC) demonstrates altering patients' static balance improving gait parameters. Other cannabinoids like cannabigerol (CBG) cannabichromene (CBC) exhibit anti-inflammatory anticonvulsant properties, respectively. However, further research warranted validate their efficacy psychiatric disorders, including Conclusion: Phytocannabinoids promising effects various neuropsychological conditions, Although use shows tolerability among rigorous are necessary establish true effectiveness benefits dementia management.

Язык: Английский

The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury DOI Creative Commons
Xiaopeng Zhao, Zheng Wang, Lijie Wang

и другие.

Pharmacological Research, Год журнала: 2024, Номер 209, С. 107466 - 107466

Опубликована: Окт. 15, 2024

Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received attention. Oxidative stress, multiple programmed cell deaths, inflammation and others are all essential contributing to MIRI. Mitochondria energy supply centers cells. Numerous studies found that abnormal mitochondrial function is an "culprit" MIRI, mitophagy mediated phosphatase tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin signaling pathway integral part maintaining function. Therefore, exploring association between PINK1/Parkin pathway-mediated crucial. This review will mainly summarize crucial role in MIR-induced several various potential interventions affect mitophagy, thus ameliorating

Язык: Английский

Процитировано

5
Cannabinoids and monoaminergic system: implications for learning and memory DOI Creative Commons
Sha Zhao,

Zhaoliang Gu,

Ya-Nan Yue

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Авг. 14, 2024

Cannabinoids and the endocannabinoid system (ECS) have been intensively studied for their neuroregulatory roles in central nervous (CNS), especially regulating learning memory. However, many experimental clinical studies obtained conflicting results indicating a complex network of interaction underlying regulation memory by different cannabinoids ECS. The ECS influences neuronal synaptic communications, therefore may exert via impact on other neurotransmitters. monoaminergic includes variety neurotransmitters, such as dopamine, norepinephrine, serotonin, which play important mood, cognition, reward. among cannabinoids, has drawn particular attention, contributions to In this review, we summarized current understanding how contribute process memory, discussed neurotransmission during process.

Язык: Английский

Процитировано

3
The endocannabinoid and paracannabinoid systems in natural reward processes: possible pharmacological targets? DOI Creative Commons
Marzia Friuli, Barbara Eramo,

C. Sepe

и другие.

Physiology & Behavior, Год журнала: 2025, Номер 296, С. 114929 - 114929

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
A review of cellular and molecular interactions between endocannabinoids and male fertility: Balancing beneficial and detrimental effects DOI

Shadi Mohammadpour-Asl,

Ali Parvin,

Naeimeh Akbari‐Gharalari

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123778 - 123778

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Tetrahydrocannabinol and dopamine D1 receptor DOI Creative Commons
Jiwon Lee

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Фев. 14, 2024

Dopamine is a hormone that released by the adrenal gland and influences motor control motivation. known to have 5 receptors which are D1, D2, D3, D4 D5, further categorized into 2 families: D1 family D2 family. The play role in motivation whereas affect attention sleep. THC, type of cannabinoid, can lead feelings euphoria, anxiety, fear, distrust, or panic. THC dopamine regions such as anterior cingulate cortex (ACC), plays fundamental cognitive processes. Although there vast amount research between relationship on dopamine, continues be limited relation receptors. receptor several essential functions, memory, attention, impulse control, regulation renal function, locomotion. Accordingly, this review intended summarize receptors, highlighting key gaps literature avenues for future research.

Язык: Английский

Процитировано

2
DELVE INTO THE SYNTHESIS AND CHEMISTRY OF PHYTOCANNABINOIDS, EMPHASIZING THEIR POTENTIAL AS THERAPEUTIC ALTERNATIVES FOR NEUROPSYCHOLOGICAL DISORDERS, INCLUDING ALZHEIMER DOI Creative Commons

Sudhair Abbas Bangash,

Bilal tayab,

Mr. Hassan Saleemi

и другие.

Опубликована: Фев. 29, 2024

Introduction: Alzheimer's disease, a progressive neurodegenerative condition, induces memory loss and cognitive impairments, posing significant challenges for patients, families, caregivers. Cannabidiol (CBD), derived from cannabis, exhibits neuroprotective properties influences cognition behavior. Its therapeutic potential in treatment is increasingly recognized, aiming to alleviate symptoms improve patient outcomes. Objectives: This study aims conduct an integrative review of cannabinoids' effects, particularly CBD, treating disease. Methods: An literature was conducted explore the impact cannabis-based treatments on patients. Key health science databases such as LILACS, PubMed, Scopus, Web Science, Google Scholar were systematically searched using relevant descriptors (e.g., Cannabidiol, Tetrahydrocannabinol, Alzheimer's, Treatment). Results: Forty studies identified selected databases, with 37 meeting eligibility criteria inclusion this review. Discussion: CBD emerges complementary option managing neurological Tetrahydrocannabinol (THC) demonstrates altering patients' static balance improving gait parameters. Other cannabinoids like cannabigerol (CBG) cannabichromene (CBC) exhibit anti-inflammatory anticonvulsant properties, respectively. However, further research warranted validate their efficacy psychiatric disorders, including Conclusion: Phytocannabinoids promising effects various neuropsychological conditions, Although use shows tolerability among rigorous are necessary establish true effectiveness benefits dementia management.

Язык: Английский

Процитировано

0