Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments DOI Creative Commons
Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

ABSTRACT Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes 3D genome organization the effect external interventions on this process, remains limited. Here we describe alterations landscape chromatin interactome upon aging, utilizing low input Promoter Capture Hi-C (liCHi-C) technique with hippocampal neurons. We integrated liCHi-C data RNA-seq to identify functional implications. Furthermore, assessed exposure environmental enrichment (EE). Remarkably, results demonstrated an age- dependent modulation promoter interactions expression EE, aging-like induced young mice likely associated early brain maturation; while were reverted old mice, leading partial rejuvenation aged mouse hippocampi. These findings revealed dynamic behaviour neuronal structure over time, which can be modulated by interventions.

Язык: Английский

Chronic stress-induced neuroplasticity in the prefrontal cortex: Structural, functional, and molecular mechanisms from development to aging DOI
Sami A. Algaidi

Brain Research, Год журнала: 2025, Номер unknown, С. 149461 - 149461

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Estradiol effects on astrocytic aquaporin 4 and glutamate transporter 1 expression contribute to shifts in brain dynamics supporting spatial working memory. DOI
Julie J. McInvale, Louisa Kuper,

Evelyn Li

и другие.

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115578 - 115578

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Social Isolation Induces Changes in the Monoaminergic Signalling in the Rat Medial Prefrontal Cortex DOI Creative Commons
Vivien Csikós, Fanni Dóra,

Tamás Láng

и другие.

Cells, Год журнала: 2024, Номер 13(12), С. 1043 - 1043

Опубликована: Июнь 17, 2024

(1) Background: The effects of short-term social isolation during adulthood have not yet been fully established in rats behaviourally, and at all transcriptomically the medial prefrontal cortex (mPFC). (2) Methods: We measured behavioural housing adult male pairs or alone for 10 days. also used RNA sequencing to measure accompanying gene expression alterations mPFC rats. (3) Results: isolated animals exhibited reduced sociability novelty preference, but increased interaction. There was no change their aggression, anxiety, depression-like activity. Transcriptomic analysis revealed a differential 46 genes between groups. KEGG pathway showed that differentially expressed are involved neuroactive ligand-receptor interactions, particularly dopaminergic peptidergic systems, addiction. Subsequent validation confirmed decreased level three altered genes: regulator G protein signalling 9 (Rgs9), serotonin receptor 2c (Htr2c), Prodynorphin (Pdyn), which dopaminergic, serotonergic, function, respectively. Antagonizing Htr2c its role discrimination. (4) Conclusions: Social homeostatic regulations include monoaminergic systems mPFC.

Язык: Английский

Процитировано

3
Age-Dependent Maturation and Rejuvenation of the Neural 3D Chromatin Interactome in Enriched Environments DOI Creative Commons
Javier Gancedo-Verdejo, Rocío G. Urdinguio, Juan Ramón Tejedor

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

ABSTRACT Aging is a multifactorial biological process resulting in physiological and cellular decline. However, our understanding of age-related changes 3D genome organization the effect external interventions on this process, remains limited. Here we describe alterations landscape chromatin interactome upon aging, utilizing low input Promoter Capture Hi-C (liCHi-C) technique with hippocampal neurons. We integrated liCHi-C data RNA-seq to identify functional implications. Furthermore, assessed exposure environmental enrichment (EE). Remarkably, results demonstrated an age- dependent modulation promoter interactions expression EE, aging-like induced young mice likely associated early brain maturation; while were reverted old mice, leading partial rejuvenation aged mouse hippocampi. These findings revealed dynamic behaviour neuronal structure over time, which can be modulated by interventions.

Язык: Английский

Процитировано

0