Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough
European Journal of Neuroscience,
Год журнала:
2024,
Номер
60(1), С. 3466 - 3490
Опубликована: Май 10, 2024
Abstract
In
females,
Alzheimer's
disease
(AD)
incidences
increases
as
compared
to
males
due
estrogen
deficiency
after
menopause.
Estrogen
therapy
is
the
mainstay
for
menopause
and
associated
complications.
Estrogen,
a
hormone
with
multifaceted
physiological
functions,
has
been
implicated
in
AD
pathophysiology.
plays
crucial
role
amyloid
precursor
protein
(APP)
processing
overall
neuronal
health
by
regulating
various
factors
such
brain‐derived
neurotrophic
factor
(BDNF),
intracellular
calcium
signalling,
death
domain‐associated
(Daxx)
translocation,
glutamatergic
excitotoxicity,
Voltage‐Dependent
Anion
Channel,
Insulin‐Like
Growth
Factor
1
Receptor,
estrogen‐metabolising
enzymes
apolipoprotein
E
(ApoE)
polymorphisms.
All
these
impact
physiology
of
postmenopausal
women.
replacement
therapies
play
an
important
treatment
strategy
prevent
However,
use
may
lead
increased
risks
breast
cancer,
venous
thromboembolism
cardiovascular
disease.
Various
therapeutic
approaches
have
used
mitigate
effects
on
AD.
These
include
therapy,
Selective
Receptor
Modulators
(SERMs),
Beta
(ERβ)‐Selective
Agonists,
Transdermal
Delivery,
Localised
Combination
Therapies,
Metabolism
Modulation
Alternative
Estrogenic
Compounds
like
genistein
from
soy,
notable
phytoestrogen
plant
sources.
mechanism
via
which
modulate
women
not
explained
earlier
thoroughly.
Present
review
will
enlighten
all
molecular
mechanisms
Along‐with
this,
association
between
estrogen,
ApoE
polymorphisms
also
be
discussed
Язык: Английский
Epigenetic Biomarkers in Alzheimer's Disease: Diagnostic and Prognostic Relevance
Ageing Research Reviews,
Год журнала:
2024,
Номер
102, С. 102556 - 102556
Опубликована: Окт. 30, 2024
Язык: Английский
Bibliometric Study of Periodontitis and Alzheimer\'s Disease: Trends, Collaboration, and Emerging Patterns
The Journal of Contemporary Dental Practice,
Год журнала:
2024,
Номер
25(9), С. 863 - 868
Опубликована: Дек. 19, 2024
To
perform
a
bibliometric
study
of
periodontal
disease
and
Alzheimer's
(AD)
focusing
on
trends,
collaborative
efforts,
emerging
patterns.
From
January
2018
to
May
2024,
an
observational
was
carried
out
utilizing
metadata
extracted
from
the
Scopus
database.
A
search
methodology,
specifically
designed
for
this
database,
developed
using
MeSH
terms
combined
with
Boolean
operators
such
as
"AND"
"OR".
The
Bibliometrix
tool
employed
facilitate
study,
indicators
including
number
citations
publications,
authorship
publication,
country
origin,
year
type
H-index,
WorldMap,
Sankey
diagram,
keyword
analysis,
topic
evolution,
scientific
findings.
total
50.7
27.3%
publications
were
in
Q1
Q2
quartile
journals.
University
Central
Lancashire
has
most
(17),
but
California
at
San
Francisco
highest
impact
(1545
per
publication).
journal
Periodontology
2000
had
643
publication.
Sim
Kaur
Singhrao
(16)
Ingar
Olsen
(10)
authors
whereas
Eric
C
Reynolds
1,300
citations.
This
found
gradual
growth
studies
during
2021
2022,
followed
by
decrease
subsequent
years,
journals
predominating.
In
productivity,
United
States
is
leading
area
research.
citations,
demonstrating
particular
interest
periodontology
studying
association
between
systemic
diseases.
present
significant
because
relationship
periodontitis
Alzheimer
currently
considered
novel
multidisciplinary
research
opportunity,
given
that
it
includes
both
medical
dental
specialties.
also
provides
valuable
contribution
academics,
universities,
centers
will
allow
us
understand
trends
new
horizons
identify
productive
authors.
How
cite
article:
Matta-Pacheco
J,
Tsukamoto-Jaramillo
A,
Tinedo-López
PL,
Язык: Английский
Research hotspots and trends of epigenetic therapy in oncology: a bibliometric analysis from 2004 to 2023
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 12, 2024
Epigenetics
denotes
heritable
alterations
in
gene
expression
patterns
independent
of
changes
DNA
sequence.
Epigenetic
therapy
seeks
to
reprogram
malignant
cells
a
normal
phenotype
and
has
been
extensively
investigated
oncology.
This
study
conducts
bibliometric
analysis
epigenetic
cancer,
providing
comprehensive
overview
current
research,
identifying
trends,
highlighting
key
areas
investigation.
Язык: Английский
Integrating epigenetic modification and stem cell therapy strategies: A novel approach for advancing Alzheimer's disease treatment - A literature review.
PubMed,
Год журнала:
2024,
Номер
4(3), С. e935 - e935
Опубликована: Дек. 1, 2024
Alzheimer's
disease
(AD)
is
the
most
frequent
form
of
dementia
and
represents
an
increasing
global
burden,
particularly
in
countries
like
Indonesia,
where
population
has
begun
to
age
significantly.
Current
medications,
including
cholinesterase
inhibitors
NMDA
receptor
antagonists,
have
modest
effects
on
clinical
symptoms
early
middle
stages,
but
there
no
curative
treatment
available
so
far
despite
progress.
Activating
or
repressing
epigenetic
modifications,
DNA
methylation,
histone
modification
microRNA
regulation,
appears
play
important
role
AD
development.
These
alterations
further
enact
transcriptional
changes
relevant
signature
pathologies
amyloid-β
deposition,
tau
protein
malfunctioning,
neuroinflammation,
neuronal
death.
Here,
we
discuss
feasibility
targeting
these
as
a
new
strategy
due
reversibility
epigenetics
their
ability
correct
faulty
gene
expression.
We
also
review
combined
promise
stem
cell
therapies
modulation
neurodegeneration,
inflammation
cognitive
decline.
This
approach
may
provide
multifaceted
slow
progression,
replace
lost
neurons,
restore
neural
function.
Despite
challenges,
ethical,
financial,
methodological
barriers,
ongoing
research
therapy
holds
for
pioneering
AD.
Язык: Английский