The Effectiveness of Computerized Cognitive Training in Patients with Post-Stroke Cognitive Impairment: A Systematic Review and Meta-analysis (Preprint)

Опубликована: Фев. 27, 2025

Stroke often triggers post-stroke cognitive impairment (PSCI) within six months, impairing memory, attention, and executive function while exacerbating physical disabilities mortality. Computerized training (CCT) is a promising treatment approach. Compared to traditional methods, CCT provides cost-effective, easily accessible, personalized repetitive rehabilitation training. Therefore, we performed systematic review of the efficacy improve in patients with PSCI supplemented findings meta-analysis. To evaluate comparison usual care or routine for PSCI, aim providing clinicians therapists more effective convenient therapeutic options. The search was conducted across multiple databases, including PubMed, Web Science, Embase, Cochrane Library, Scopus, covering publications from 2010 June 2024, focus on English-language articles. primary outcome measured function, assessed through standardized scales, secondary outcomes included daily living activities motor patients. risk bias evaluated using Risk Bias tool, quality evidence determined according GRADE framework. A total nineteen trials were meta-analysis (n = 880 participants). provided moderate high-quality indicating that significantly enhances general (15 trials, mean difference [SMD]= 0.46, 95% CI 0.21 0.71; P <.001, I2 60%), attention (11 SMD -0.41, -0.62 -0.20; 15%), (6 0.39, 0.12 0.67; =.005, 0%), life (9 0.34, 0.15 0.53; 6%). However, low very indicated has limited improvement language can enhance PROSPERO, CRD42024573594.

Язык: Английский

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Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 1869 - 1894

Опубликована: Март 1, 2025

Polygala tenuifolia Willd. (PT) is commonly used to address cognitive impairment (CI), while Magnolia officinalis Rehd. et Wils (MO) often prescribed for gastrointestinal issues as well CI. This study seeks explore the impacts and mechanisms behind combined therapy of PT MO (PM) in treating CI, based on concept gut-brain axis. The characteristic components PT, MO, PM were identified using ultra-high performance liquid chromatography-tandem triple quadrupole mass Spectrometry (UPLC-MS/MS). A mouse model was established by D-gal induction, effects CI evaluated through behavioral tests, pathological staining, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, network pharmacology analyze potential which improves followed validation Western blotting (WB), traditional Chinese medicine (TEM), Immunofluorescence (IF), 16S rRNA. can each alleviate decline neuropathological damage mice varying degrees, reduce expression pro-inflammatory factors (TNF-α, IL-1β, IL-6, IFN-γ, LPS) serum or hippocampal tissue, increase SOD GSH levels. Network analysis molecular experiments confirmed that upregulates tight junction s (TJs), enhances proteins cAMP pathway, inhibits p-NF-κB-p65 expression. reverses D-gal-induced gut microbiota dysbiosis, increases abundance SCFA-producing bacteria, decreases LPS-producing bacteria. alleviates reducing inflammation oxidative stress, protecting blood-brain barrier (BBB) intestinal barrier, inhibiting NF-κB activating regulating microbiota.

Язык: Английский

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Nuclear factor erythroid 2-related factor improves depression and cognitive dysfunction in rats with ischemic stroke by mediating wolfram syndrome 1

Brain Research, Год журнала: 2025, Номер unknown, С. 149572 - 149572

Опубликована: Март 1, 2025

Язык: Английский

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