Mitophagy in perioperative neurocognitive disorder: mechanisms and therapeutic strategies
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Апрель 11, 2025
Perioperative
neurocognitive
disorder
(PND)
is
a
common
neurological
complication
after
surgery/anesthesia
in
elderly
patients
that
affect
postoperative
outcome
and
long-term
quality
of
life,
which
increases
the
cost
family
social
resources.
The
pathological
mechanism
PND
complex
not
fully
understood,
methods
prevention
treatment
are
very
limited,
so
it
particularly
important
to
analyze
PND.
Research
indicates
mitochondrial
dysfunction
pivotal
initiation
progression
PND,
although
precise
mechanisms
remain
elusive
could
involve
disrupted
mitophagy.
We
reviewed
recent
studies
on
link
between
mitophagy
highlighting
role
key
proteins
abnormal
discussing
therapeutic
strategies
aimed
at
regulation.
This
provides
insights
into
underlying
potential
targets.
Язык: Английский
Targeting necroptosis in Alzheimer’s disease: can exercise modulate neuronal death?
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Март 14, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
cognitive
decline
and
neuronal
degeneration.
Emerging
evidence
implicates
necroptosis
in
AD
pathogenesis,
driven
the
RIPK1-RIPK3-MLKL
pathway,
which
promotes
damage,
inflammation,
progression.
Exercise,
as
non-pharmacological
intervention,
can
modulate
key
inflammatory
mediators
such
TNF-α,
HMGB1,
IL-1β,
thereby
inhibiting
necroptotic
signaling.
Additionally,
exercise
enhances
O-GlcNAc
glycosylation,
preventing
Tau
hyperphosphorylation
stabilizing
integrity.
This
review
explores
how
mitigates
neuroinflammation,
offering
novel
therapeutic
perspectives
for
prevention
management.
Язык: Английский
Aerobic exercise, an effective intervention for cognitive impairment after ischemic stroke
Frontiers in Aging Neuroscience,
Год журнала:
2025,
Номер
17
Опубликована: Апрель 4, 2025
Cognitive
dysfunction
is
a
common
and
debilitating
complication
following
ischemic
stroke,
significantly
impairing
the
quality
of
life
patients.
In
recent
years,
aerobic
exercise
has
emerged
as
promising
non-pharmacological
intervention
to
mitigate
post-stroke
cognitive
impairment
(PSCI).
This
review
synthesizes
current
evidence
on
efficacy
mechanisms
in
enhancing
recovery
after
stroke.
Key
include
improved
cerebral
hemodynamics
through
enhanced
blood
flow
(CBF),
promotion
neuroplasticity
via
brain-derived
neurotrophic
factor
(BDNF)-mediated
pathways,
suppression
neuroinflammation
(e.g.,
NLRP3
inflammasome
inhibition),
attenuation
oxidative
stress.
Preclinical
clinical
studies
demonstrate
that
modalities
such
gait
training,
cycling,
aquatic
therapy
enhance
domains
including
memory,
executive
function,
attention,
with
optimal
benefits
observed
at
moderate-to-high
intensity
frequency
≥3
sessions
per
week.
Despite
robust
evidence,
challenges
remain
standardizing
protocols
addressing
individual
variability
treatment
response.
Future
research
should
prioritize
large-scale
randomized
controlled
trials
validate
long-term
identify
biomarkers
for
personalized
rehabilitation
strategies.
underscores
imperative
integrate
into
paradigms,
offering
dual
therapeutic
approach
improve
both
physical
outcomes.
Язык: Английский
The Role of Ion-Transporting Proteins on Crosstalk Between the Skeletal Muscle and Central Nervous Systems Elicited by Physical Exercise
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Язык: Английский
The Impact of Physical Activity on Neuroprotection in Neurodegenerative Diseases: A Special Focus on Parkinson’s Disease
Quality in Sport,
Год журнала:
2024,
Номер
36, С. 56588 - 56588
Опубликована: Дек. 22, 2024
Aim
of
the
studyThis
study
examines
impact
physical
activity
on
neuroprotection
in
neurodegenerative
diseases,
focusing
Parkinson’s
Disease
(PD).
It
evaluates
neuroprotective
mechanisms,
analyzes
activity’s
role
PD
progression,
assesses
various
exercise
forms’
effectiveness
symptoms,
and
identifies
research
challenges
future
directions.
Materials
methodsA
comprehensive
literature
search
was
conducted
across
major
databases,
prioritizing
studies
from
past
15
years,
particularly
longitudinal
randomized
controlled
trials.
The
review
critically
evaluated
specificity,
effects
symptoms.
State
knowledgeRegular
enhances
neuroplasticity,
regulates
neurotrophic
factors,
reduces
oxidative
stress,
mitigates
inflammation
patients.
Various
forms
show
managing
symptoms
potentially
slowing
disease
progression.
Challenges
remain
optimizing
interventions
for
individual
patients
integrating
into
management
strategies.
ConclusionsThe
highlights
significant
PD,
demonstrating
its
potential
to
manage
slow
Research
gaps
persist
regarding
long-term
personalized
interventions.
Future
should
focus
protocols,
investigating
synergistic
with
pharmacological
treatments,
developing
This
supports
as
a
valuable
adjunctive
therapy
influencing
treatment
paradigms
disorders.
Язык: Английский