T-Type Voltage-Gated Calcium Channels: Potential Regulators of Smooth Muscle Contractility

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12420 - 12420

Опубликована: Ноя. 19, 2024

Emerging evidence has indicated a possible link between attenuation of contractility in aortic smooth muscle cells and pathogenesis dissection, as revealed through comprehensive, multi-omic analyses familial thoracic aneurysm dissection models. While L-type voltage-gated calcium channels have been extensively investigated for their roles contraction, more recent investigations suggested that downregulation T-type channels, rather than counterparts, may be closely associated with impaired observed vascular cells. This review provides detailed examination highlighting structure, electrophysiology, biophysics, expression patterns, functional roles, potential mechanisms which contribute to reduced contractile function. Furthermore, the application approaches investigating is discussed.

Язык: Английский

Zebrafish as a model to understand extraocular motor neuron diversity

Current Opinion in Neurobiology, Год журнала: 2024, Номер 90, С. 102964 - 102964

Опубликована: Дек. 30, 2024

Язык: Английский