The Protein Corona Paradox: Challenges in Achieving True Biomimetics in Nanomedicines

Biomimetics, Год журнала: 2025, Номер 10(5), С. 276 - 276

Опубликована: Апрель 29, 2025

Nanoparticles introduced into biological environments rapidly acquire a coating of biomolecules, forming biocorona that dictates their fate. Among these proteins play key role, but interaction with nanoparticles during the adsorption process often leads to unfolding and functional loss. Evidence suggests protein denaturation within alters cellular recognition, signaling pathways, immune responses, significant implications for nanomedicine nanotoxicology. This review explores dynamic nature corona, emphasizing influence local milieu on its stability. We synthesize findings from studies examining physicochemical properties nanoparticles—such as surface charge, hydrophobicity, curvature—that contribute structural perturbations. Understanding factors governing stability nanoparticle surfaces is essential designing nanomaterials improved targeting, biocompatibility, controlled interactions. underscores importance preserving conformational integrity in development biomedical applications.

Язык: Английский

Investigation on topology-dependent adsorption and aggregation of protein on nanoparticle surface enabled by integrating time-limited proteolysis with cross-linking mass spectrometry

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138511 - 138511

Опубликована: Дек. 1, 2024

Язык: Английский