<p><strong>Despite
major
advances
in
neuroscience,
there
has
been
limited
progress
improving
pharmacological
treatment
for
neuropsychiatric
disorders.
Neuropsychiatric
disorders
are
heterogenous
with
variance
symptoms
within
and
partial
overlap
between
disorders,
leading
to
that
remain
untreated.
To
improve
outcomes,
the
Research
Domain
Criteria
(RDoC)
was
created
provide
researchers
a
framework
examining
neurobiological
mechanisms
underlying
individual
components,
or
dysfunctions,
across
Anhedonia,
asociality
avolition
three
excellent
examples
of
prominent
associated
poor
functional
outcome
disorders.</strong></p><p>This
thesis
aimed
use
an
RDoC
approach
investigate
anhedonia,
avolition.
this
aim,
rats
selective
genetic
reduction
dopamine
D1
receptor
(DAD1-/-
mutants)
underwent
series
five
studies
their
lifespan
examined
role
anticipatory
consummatory
pleasure,
social
play
behaviour,
socio-emotional
communication,
motivation.
Additionally,
previous
research
DAD1-/-
mutants
used
only
males;
expanded
on
work
by
including
both
sexes
explored
possibility
sex
differences
each
study.
The
overall
hypothesis
is
implicated
avolition,
therefore
mutant
were
predicted
exhibit
reduced
anticipation
rewards,
engagement
exertion
effort
lifespan.
results
showed
led
blunted
motivation
diminished
while
pleasure
not
impacted.
There
marked
some
measures
such
as
stability
sessions
effort.
Ultimately,
furthered
research,
implicating
clear
which
could
be
targeted
treatment.
In
addition,
supported
vital
importance
animal
address
strong
focus
males
neuroscience
receptors
general.</p>
Neuroscience & Biobehavioral Reviews,
Год журнала:
2023,
Номер
152, С. 105319 - 105319
Опубликована: Июль 14, 2023
Social
play
behaviour
is
a
highly
energetic
and
rewarding
activity
that
of
great
importance
for
the
development
brain
behaviour.
abundant
during
juvenile
early
adolescent
phases
life,
it
occurs
in
most
mammalian
species,
as
well
certain
birds
reptiles.
To
date,
majority
research
into
neural
mechanisms
social
has
been
performed
male
rats.
In
present
review
we
summarize
studies
on
neurobiology
rats,
including
work
pharmacological
genetic
models
autism
spectrum
disorders,
life
manipulations
environmental
factors
influence
We
describe
several
recent
developments
expand
field,
highlight
outstanding
questions
may
guide
future
studies.
Developmental Psychobiology,
Год журнала:
2025,
Номер
67(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Long‐term
effects
of
social
play
on
neural
and
behavioral
development
remain
unclear.
We
investigated
whether
just
1
h
juvenile
could
rescue
the
deprivation
stress‐related
behavior
markers
plasticity.
Syrian
hamsters
were
reared
from
postnatal
days
21–43
in
three
conditions:
peer
isolation,
isolation
with
daily
sessions
(dyadic
play),
or
group‐housed
littermates.
In
adulthood,
subjects
exposed
to
acute
defeat
stress,
we
examined
changes
perineuronal
net
(PNN)
expression
surrounding
parvalbumin
(PV)
neurons
prelimbic
(PL),
infralimbic
(IL),
basolateral
amygdala
(BLA).
Peer
led
exaggerated
submissive
defensive
a
conditioned
test,
but
dyadic
rescued
heightened
response
both
males
females.
females,
reduced
PNN/PV
coexpression
PL
IL
compared
control
groups
opportunities
for
play.
Males
showed
elevated
agonistic
when
returned
their
littermates
1‐h
encounters.
These
findings
indicate
has
long‐lasting
PNN
PV
cells
medial
prefrontal
cortex,
which
allows
species’
typical
greater
stress
resistance
adulthood.
The
ability
highlights
powerful
role
interactions
development.
Annual Review of Neuroscience,
Год журнала:
2023,
Номер
46(1), С. 321 - 339
Опубликована: Март 31, 2023
Rapid
advances
in
the
neural
control
of
social
behavior
highlight
role
interconnected
nodes
engaged
differential
information
processing
to
generate
behavior.
Many
innate
behaviors
are
essential
reproductive
fitness
and
therefore
fundamentally
different
males
females.
Programming
these
differences
occurs
early
development
mammals,
following
gonadal
differentiation
copious
androgen
production
by
fetal
testis
during
a
critical
period.
Early-life
programming
its
adult
manifestation
separate
but
yoked
processes,
yet
how
they
linked
is
unknown.
This
review
seeks
that
gap
identifying
four
core
mechanisms
(epigenetics,
cell
death,
circuit
formation,
hormonal
modulation)
could
connect
developmental
changes
mating
aggression.
We
further
propose
unique
behavior,
adolescent
play,
bridges
preweaning
postpubertal
brain
engaging
same
networks
underpinning
aggressive
behaviors.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Cannabis
is
the
most
frequently
used
illicit
drug
during
pregnancy,
with
use
steadily
increasing
in
United
States
as
legalization
and
decriminalization
expand
to
more
states.
Many
pregnant
individuals
cannabis
reduce
adverse
symptoms
of
considering
it
be
less
harmful
than
other
pharmaceuticals
or
alcohol.
The
primary
psychoactive
component
cannabis,
delta-9-tetrahydrocannabinol
(THC),
acts
on
endocannabinoid
(eCB)
system,
yet
whether
perturbs
neural
development
fetus
poorly
understood.
Previously
we
have
shown
that
androgen
mediated
eCB
tone
developing
amygdala
promotes
microglial
phagocytosis
newborn
astrocytes
which
has
enduring
consequences
circuits
regulating
sex
differences
social
behavior.
Microglia
are
resident
immune
cells
brain
express
both
receptors
CB1R
CB2R,
making
them
likely
targets
modulation
by
THC.
It
also
plausible
exposure
THC
at
differing
gestational
timepoints
can
result
distinct
outcomes,
case
alcohol
exposure.
To
model
human
either
late
early
exposed
rodents
directly
postnatal
period
via
intraperitoneal
(IP)
injection
utero
prenatal
dam
IP
respectively.
Here
show
results
specific
changes
well
behavior
juvenile
period.
Interestingly
resulted
inverse
These
findings
highlight
differential
effects
across
gestation.
Developmental Psychobiology,
Год журнала:
2024,
Номер
66(2)
Опубликована: Янв. 21, 2024
Abstract
Reduced
play
experience
over
the
juvenile
period
leads
to
adults
with
impoverished
social
skills
and
anatomical
physiological
aberrations
of
neurons
found
in
medial
prefrontal
cortex
(mPFC).
Even
rearing
rats
from
high‐playing
strains
low‐playing
show
these
developmental
consequences.
In
present
study,
we
evaluated
whether
benefit
being
reared
higher
playing
peers.
To
test
this,
male
Fischer
344
(F344),
typically
thought
be
a
strain,
Long–Evans
(LE)
peer,
relatively
strain.
As
juveniles,
F344
LE
experienced
less
lower
quality
compared
those
another
F344.
adults,
partners
exhibited
poorer
pyramidal
their
mPFC
had
larger
dendritic
arbors
than
same‐strain
These
findings
that
more
playful
partner
does
not
improve
outcomes
rats,
rather
discordance
styles
outcomes.
Play
fighting
has
been
one
of
the
most
intensely
studied
forms
play
and
so
provided
some
our
deepest
insights
into
understanding
in
general.
As
label
implies,
this
behavior
resembles
serious
fighting,
that
animals
compete
for
an
advantage
over
another,
but
unlike
true
aggression,
to
remain
playful,
it
also
incorporates
a
degree
cooperation
reciprocity
–
restrained
competition
seems
be
its
hallmark.
Despite
these
common
features,
should
noted
both
competed
mechanisms
by
which
restraint
is
achieved
varies
across
species.
Such
variation
mitigates
simple
generalities.
For
example,
how
empirical
support
proposed
adaptive
function
species
not
being
replicated
interpreted.
What
emerged
past
few
decades
diverse,
varying
several
dimensions,
superficial,
fundamental,
making
choosing
compare
challenge.
In
paper,
we
explore
various
design
features
constitute
ways
can
modified
different
lineages
Given
major
pillar
ethology
description
precedes
explanation,
having
good
grasp
behavioral
diversity
essential
starting
point
detailed
analyses
functions
play.
We
show
commonalities
likely
involve
than
do
idiosyncrasies,
styles
afford
opportunities.
European Journal of Neuroscience,
Год журнала:
2024,
Номер
59(10), С. 2748 - 2765
Опубликована: Март 21, 2024
Abstract
Social
play
behaviour
is
a
rewarding
activity
that
can
entail
risks,
thus
allowing
young
individuals
to
test
the
limits
of
their
capacities
and
train
cognitive
emotional
adaptability
challenges.
Here,
we
tested
in
rats
how
opportunities
for
risk‐taking
during
affect
development
medial
prefrontal
cortex
(mPFC)
function,
brain
structure
important
risk‐based
decision
making.
Male
female
were
housed
socially
or
social
play‐deprived
(SPD)
between
postnatal
day
(P)21
P42.
During
this
period,
half
both
groups
daily
exposed
high‐risk
environment.
Around
P85,
all
performance
after
which
inhibitory
currents
recorded
layer
5
pyramidal
neurons
mPFC
slices.
We
show
playing
environment
altered
flexibility
sexes
improved
behavioural
inhibition
males.
High‐risk
anxiety‐like
elevated
plus
maze
males
open
field
females,
respectively.
SPD
affected
decreased
females.
found
synaptic
increased
male,
but
not
female,
play,
while
lowered
(PFC)
sexes.
Together,
our
data
exposure
risks
affects
cognition,
mPFC.
Furthermore,
study
suggests
opportunity
take
cannot
substitute
behaviour.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 11, 2024
Abstract
Like
many
mammals,
as
juveniles,
rats
engage
in
play
fighting,
which
the
laboratory
is
typically
studied
dyads,
and
consequently,
it
researcher
who
determines
a
rat’s
partner.
In
real-life
conditions,
rat
would
have
partners
with
whom
to
play.
previous
study,
we
found
that
do
prefer
some
individuals
more
than
others,
surprisingly,
when
given
choice,
unfamiliar
are
preferred
familiar
ones.
this
assessed
partner
choice
all
available
strangers.
Eight
groups
of
six
juvenile
male
were
observed
for
10
min
trials.
One
each
group
was
selected
‘focal’
his
towards,
received
by,
others
scored.
Social
networks
revealed
five
eight
formed
preferences,
also
engaging
focal
rat.
The
mechanism
by
these
preferences
remains
be
determined,
but
seems
there
individual
differences,
potentially
amount
style
play,
allow
an
select
most
suitable
from
