Establishing the pig as a translational animal model for neurodevelopment
Translational Neuroscience,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 1, 2025
Abstract
Background
Within
the
last
few
decades,
domestic
pig
has
emerged
as
an
advantageous
biomedical
animal
model
due
to
a
vast
number
of
similarities
in
realms
development
and
neuroanatomical
features.
Even
so,
major
challenge
remains
how
translate
time
between
human.
Previously,
researchers
have
developed
Translating
Mammalian
Time
that
estimates
timing
95
neurodevelopmental
events
across
9
mammalian
species.
By
identifying
these
various
events,
one
can
include
additional
into
assign
unique
species
score
predict
post-conception
day
(PCD)
other
will
occur.
Objective
Our
objective
was
conduct
comprehensive
literature
review
enable
chronological
comparison
species,
including
humans.
Methods
A
total
30
with
corresponding
PCDs
were
identified,
then
used
optimize
pig’s
using
grid
search
gradient
descent
approaches.
Results
Conclusion
Across
both
methods,
same
2.157
derived
residual
sum
squares
4260.46.
This
places
cat
(1.808)
macaque
(2.255),
thereby
reinforcing
translational
power
comparable
non-human
primates.
Язык: Английский
Validating an updated protocol for the novel object recognition task in young pigs
Frontiers in Behavioral Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Март 31, 2025
The
objective
of
this
study
was
to
validate
equipment
and
procedures
involved
in
implementing
the
novel
object
recognition
(NOR)
paradigm
with
young
pigs.
Two
experiments
were
run
intent
determining
improvements
original,
high-throughput
NOR
design.
focus
these
impact
confounding
factors
on
main
cognitive
outcome,
index
(RI).
Experiment
1
utilized
13
pigs
that
all
performed
task
following
original
addition
2
extra
testing
days.
Results
from
experiment
indicated
one
test
day
is
sufficient
for
producing
RI
values
differ
(p
<
0.05)
chance
performance,
which
set
at
0.50
given
use
two
objects.
also
may
habituate
itself
after
as
not
different
>
days
or
3.
male
16
female
determine
sex
differences
outcomes
introducing
home-cage
enrichment.
investigative
behaviors
despite
both
sexes
chance.
enrichment
less
discernable,
but
evidence
suggests
a
lack
influence.
Overall,
modifications
described
herein
reduced
variability
primary
RI,
thereby
improved
sensitivity
behavioral
assay
compared
paradigm.
Язык: Английский