Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1 DOI Creative Commons
Nobuhiko Wagatsuma,

Yuka Terada,

Hiroyuki Okuno

и другие.

Frontiers in Systems Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 19, 2025

Environmental enrichment, an enhancement in the breeding environment of laboratory animals, enhance development cortical circuit and suppresses brain dysfunction. We quantitatively investigated influences enriched (EE) exposure, on responses layers 2/3 (L2/3) primary visual area (V1) mice. EE modifies cortex plasticity by inducing immediate early genes. To detect this, we performed immunostaining for gene product c-Fos. exposure significantly increased number neurons with high c-Fos fluorescence intensity compared those mice under standard housing (SH). In contrast, there was no significant difference exhibiting low between SH groups. further investigate mechanism modulation developed a microcircuit model biologically plausible L2/3 V1 that combined excitatory pyramidal (Pyr) three inhibitory interneuron subclasses. model, synaptic strengths Pyr were determined according to log-normal distribution. Model simulations various inputs mimicking physiological conditions reproduced experimentally observed activity induced exposure. These results suggested connections among obeying distribution underlie characteristic EE-exposure-induced V1.

Язык: Английский

Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1 DOI Creative Commons
Nobuhiko Wagatsuma,

Yuka Terada,

Hiroyuki Okuno

и другие.

Frontiers in Systems Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 19, 2025

Environmental enrichment, an enhancement in the breeding environment of laboratory animals, enhance development cortical circuit and suppresses brain dysfunction. We quantitatively investigated influences enriched (EE) exposure, on responses layers 2/3 (L2/3) primary visual area (V1) mice. EE modifies cortex plasticity by inducing immediate early genes. To detect this, we performed immunostaining for gene product c-Fos. exposure significantly increased number neurons with high c-Fos fluorescence intensity compared those mice under standard housing (SH). In contrast, there was no significant difference exhibiting low between SH groups. further investigate mechanism modulation developed a microcircuit model biologically plausible L2/3 V1 that combined excitatory pyramidal (Pyr) three inhibitory interneuron subclasses. model, synaptic strengths Pyr were determined according to log-normal distribution. Model simulations various inputs mimicking physiological conditions reproduced experimentally observed activity induced exposure. These results suggested connections among obeying distribution underlie characteristic EE-exposure-induced V1.

Язык: Английский

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