Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome DOI Creative Commons
Costas Papatheodoropoulos

Biology, Год журнала: 2025, Номер 14(4), С. 363 - 363

Опубликована: Март 31, 2025

The excitation/inhibition (E/I) balance is a critical feature of neural circuits, which crucial for maintaining optimal brain function by ensuring network stability and preventing hyperexcitability. hippocampus exhibits the particularly interesting characteristics having different functions E/I profiles between its dorsal ventral segments. Furthermore, vulnerable to epilepsy implicated in Fragile X Syndrome (FXS), disorders associated with heightened possible deficits GABA-mediated inhibition. In epilepsy, shows susceptibility seizures, while FXS, recent evidence suggests differential alterations excitability inhibition regions. This article explores mechanisms underlying regulation, focusing on emphasizing that may confer homeostatic flexibility balance. Notably, adult FXS models enhanced GABAergic inhibition, resistance epileptiform activity, physiological pattern (sharp wave-ripples, SWRs), potentially representing adaptation. contrast, these more aberrant discharges displays altered SWRs. These findings highlight complex, region-specific nature disruptions neurological suggest possess unique compensatory mechanisms. Specifically, it proposed hippocampus, region most prone hyperexcitability, have adaptive capabilities at cellular levels maintain within normal range prevent transition hyperexcitability preserve function. Investigating responses their developmental trajectories offer novel insights into strategies mitigating imbalances other neuropsychiatric neurodevelopmental disorders.

Язык: Английский

Psychological and physiological computing based on multi-dimensional foot information DOI Creative Commons
Shengyang Li,

Huilin Yao,

Ruotian Peng

и другие.

Artificial Intelligence Review, Год журнала: 2025, Номер 58(5)

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

0
A novel prefrontal cortex and hippocampus combined brain slice based on in vivo diffusion tensor imaging of healthy male rats DOI
Lijun Zhang, Qian Zhou,

Guanghao Zhang

и другие.

Neuroscience Letters, Год журнала: 2025, Номер unknown, С. 138171 - 138171

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
The lateralized LC-NAergic system distinguishes vicarious versus direct fear in mice DOI Creative Commons
Jong‐Hyun Kim,

Dennis C. Choi,

Hee‐Sup Shin

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 10, 2025

Fear can be induced either directly through self-experience of aversive events or vicariously by observing conspecifics experiencing such events. The locus coeruleus-norepinephrine (LC-NA) system is crucial in fear responses and cognitive processes. We investigated whether the LC-NA differentially processes these two types fear, direct vicarious male mice. results highlighted that right hemisphere LC→anterior cingulate cortex pathway uniquely for while inputs to LC—from bed nucleus stria terminalis (BNST) central amygdala (CeA)—differentially contribute processing. BNST plays a more targeted role CeA has broader influence on general. This underscores complexity specialization within fear-processing. arises vicariously, with involved both. Here, authors show LC → ACC key provide distinct LC, highlighting its complex fear.

Язык: Английский

Процитировано

0
Prefrontal-hippocampal pathways underlying adolescent resilience DOI
Luqing Wei, Zhenyu Wu, Qi Xia

и другие.

European Child & Adolescent Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome DOI Creative Commons
Costas Papatheodoropoulos

Biology, Год журнала: 2025, Номер 14(4), С. 363 - 363

Опубликована: Март 31, 2025

The excitation/inhibition (E/I) balance is a critical feature of neural circuits, which crucial for maintaining optimal brain function by ensuring network stability and preventing hyperexcitability. hippocampus exhibits the particularly interesting characteristics having different functions E/I profiles between its dorsal ventral segments. Furthermore, vulnerable to epilepsy implicated in Fragile X Syndrome (FXS), disorders associated with heightened possible deficits GABA-mediated inhibition. In epilepsy, shows susceptibility seizures, while FXS, recent evidence suggests differential alterations excitability inhibition regions. This article explores mechanisms underlying regulation, focusing on emphasizing that may confer homeostatic flexibility balance. Notably, adult FXS models enhanced GABAergic inhibition, resistance epileptiform activity, physiological pattern (sharp wave-ripples, SWRs), potentially representing adaptation. contrast, these more aberrant discharges displays altered SWRs. These findings highlight complex, region-specific nature disruptions neurological suggest possess unique compensatory mechanisms. Specifically, it proposed hippocampus, region most prone hyperexcitability, have adaptive capabilities at cellular levels maintain within normal range prevent transition hyperexcitability preserve function. Investigating responses their developmental trajectories offer novel insights into strategies mitigating imbalances other neuropsychiatric neurodevelopmental disorders.

Язык: Английский

Процитировано

0