Neural circuits regulating visceral pain

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Апрель 13, 2024

Abstract Visceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development chronic visceral pain, which is major challenge for both patients and health providers. Neural circuits in brain encode, store, transfer pain information across regions. In this review, we focus on anterior cingulate cortex paraventricular nucleus hypothalamus highlight progress identifying neural involved pain. We also discuss several circuit mechanisms emphasize importance cross-species, multiangle approaches identification specific neurons determining that control

Язык: Английский

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Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(9), С. 7680 - 7680

Опубликована: Апрель 22, 2023

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world’s population. Social-cognitive impairments in SZ prevent positive social interactions and lead to progressive withdrawal. The neurobiological underpinnings social-cognitive symptoms remain poorly understood, which hinders development novel treatments. At whole-brain level, an abnormal activation brain regions interregional dysconnectivity within networks have been identified as major contributors these symptoms. cellular subcellular levels, interplay between oxidative stress, neuroinflammation N-methyl-D-aspartate receptor hypofunction thought underly pathology. However, it not clear how molecular processes are linked with genesis Here, we aim bridge gap macroscale (connectivity analyses) microscale (molecular mechanistic) knowledge by proposing impaired myelination disinhibition local microcircuits possible causative biological pathways leading activity brain. Furthermore, recommend electroencephalography promising translational technique that can foster pre-clinical drug discuss attractive targets for treatment SZ.

Язык: Английский

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BLA-involved circuits in neuropsychiatric disorders

Ageing Research Reviews, Год журнала: 2024, Номер 99, С. 102363 - 102363

Опубликована: Июнь 4, 2024

Язык: Английский

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Chemogenetic attenuation of PFC pyramidal neurons restores recognition memory deficits following adolescent NMDA receptor blockade

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111359 - 111359

Опубликована: Апрель 1, 2025

Язык: Английский

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Brain circuits that regulate social behavior

Molecular Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Social interactions are essential for the survival of individuals and reproduction populations. stressors, such as social defeat isolation, can lead to emotional disorders cognitive impairments. Furthermore, dysfunctional behaviors hallmark symptoms various neuropsychiatric disorders, including autism spectrum disorder (ASD) post-traumatic stress (PTSD). Consequently, understanding neural circuit mechanisms underlying has become a major focus in neuroscience. behaviors, which encompass wide range expressions phases, regulated by complex networks. In this review, we summarize recent progress identifying circuits involved different types general investigation, preference, mating, aggression, parenting, prosocial dominance behaviors. We also outline associated with deficits ASD, schizophrenia, PTSD. Given pivotal role rodents behavior research, our review primarily focuses on these animals. Finally, propose future research directions, development specific behavioral paradigms, identification motor output, integration activity, transcriptome, connectome data, multifunctional roles neurons multiple targets, among brain regions.

Язык: Английский

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Dysfunction of the triple-network model is associated with cognitive impairment in patients with cerebral small vessel disease

Heliyon, Год журнала: 2024, Номер 10(2), С. e24701 - e24701

Опубликована: Янв. 1, 2024

PurposeThis study aimed to demonstrate the correlations between altered functional connectivity patterns in triple-network model and cognitive impairment patients with cerebral small vascular disease (CSVD).MethodsResting-state magnetic resonance imaging data were obtained from 22 CSVD 20 healthy controls. The resting-state analyzed using independent component analysis network (FNC) explore alterations intrinsic including salience (SN), default mode (DMN), central executive (CEN), their deficits clinical observations CSVD.ResultsCompared controls, exhibited increased CEN-DMN decreased DMN-SN, CEN-SN, intra-SN, intra-DMN. Significant negative detected intra-DMN pattern Montreal Cognitive Assessment (MoCA) total scores (r = −0.460, p 0.048) MoCA abstraction −0.565, 0.012), a positive correlation was determined intra-SN 0.491, 0.033).ConclusionsOur findings suggest that are associated shed light on importance of pathogenesis CSVD.

Язык: Английский

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Progress in The Research of Lactate Metabolism Disruption And Astrocyte‐Neuron Lactate Shuttle Impairment in Schizophrenia: A Comprehensive Review

Advanced Biology, Год журнала: 2024, Номер 8(6)

Опубликована: Апрель 10, 2024

Abstract Schizophrenia (SCZ) is a complex neuropsychiatric disorder widely recognized for its impaired bioenergy utilization. The astrocyte‐neuron lactate shuttle (ANLS) plays critical role in brain energy supply. Recent studies have revealed abnormal metabolism SCZ, which associated with mitochondrial dysfunction, tissue hypoxia, gastric acid retention, oxidative stress, neuroinflammation, iron metabolism, cerebral white matter hypermetabolic activity, and genetic susceptibility. Furthermore, astrocytes, neurons, glutamate abnormalities are prevalent SCZ essential components maintaining ANLS the brain. Therefore, an in‐depth study of pathophysiological mechanisms will contribute to better understanding pathogenesis provide new ideas approaches diagnosis treatment SCZ.

Язык: Английский

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Connecting Neurobiological Features with Interregional Dysconnectivity in Social-Cognitive Impairments of Schizophrenia

Опубликована: Янв. 24, 2023

Schizophrenia (SZ) is a devastating psychiatric disorder affecting about 1% of the world’spopulation. Social-cognitive impairments in SZ prevent positive social interactions and lead toprogressive withdrawal. The neurobiological underpinnings social-cognitive symptomsremain poorly understood, which hinders development novel treatments. At wholebrainlevel, an abnormal activation brain regions interregional dysconnectivity withinsocial-cognitive networks have been identified as major contributors to these symptoms. Atthe cellular subcellular levels, interplay between oxidative stress, neuroinflammation andN-methyl-D-aspartate receptor hypofunction thought underly pathology. However, it notclear how molecular processes are linked with genesisof Here, we aim bridge gap macroscale (connectivityanalyses) microscale (molecular mechanistic) knowledge by proposing impairedmyelination disinhibition local microcircuits possible causative biological pathwaysleading activity brain. Furthermore, recommendelectroencephalography promising translational technique that can foster pre-clinical drugdevelopment discuss attractive drug targets for treatment symptoms SZ.

Язык: Английский

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Chemogenetic attenuation of PFC pyramidal neurons restores deficits in recognition memory following adolescent NMDA receptor blockade

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 11, 2024

During adolescence, the prefrontal cortex (PFC) undergoes dramatic developmental changes, including fine-tuning balance between excitatory glutamate and inhibitory GABA transmission (i.e., E/I balance). This process is critical for intact cognitive function social behavior in adulthood, its disruption associated with several psychiatric disorders schizophrenia (SZ). While acute NMDA receptor (NMDAr) blockade leads to excess PFC, long-term consequences of MK-801 administration during early adolescence on adulthood have not been extensively studied. In current study, we show that chronic abnormalities recognition memory as well reduced frequency miniature post-synaptic currents (mIPSCs) mPFC adult male rats, no change or basal activity. We further chemogenetic attenuation prelimbic pyramidal neurons reversed deficits memory, but behavior. These findings emphasize role played by NMDAr cognition adulthood. Moreover, these implicate therapeutic outcomes neuron activity early-adolescence MK-801-treated rats. Since are key components SZ, suggest future development treatments aimed at alleviating SZ should focus regulating balance.

Язык: Английский

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Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice

Molecular Pain, Год журнала: 2024, Номер 20

Опубликована: Янв. 1, 2024

The anterior cingulate cortex (ACC) is critical for pain perception, emotion and cognition. Previous studies showed that the ACC has a complex network architecture, which can receive some projection fibers from many brain regions, including thalamus, cerebral other regions. However, there was still lack of whole-brain mapping in adult mice. In present study, we utilized rabies virus-based retrograde trans-monosynaptic tracing system to map afferents unilateral We also combined with new high-throughput, high-speed high-resolution VISoR imaging technique generate three-dimensional reconstruction. Our results several principal groups structures send direct monosynaptic inputs ACC, cortex, amygdala, striatum, brainstem. found cortical neurons mainly ipsilateral projections. Some areas forebrain regions bilaterally projected ACC. These findings provide complete analysis mice, would important anatomic evidence study pain, memory,

Язык: Английский

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