Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use

Molecules, Год журнала: 2022, Номер 27(17), С. 5481 - 5481

Опубликована: Авг. 26, 2022

Despite advances in antimicrobial and anti-inflammatory therapies, inflammation its consequences still remain a significant problem medicine. Acute inflammatory responses are responsible for directly life-threating conditions such as septic shock; on the other hand, chronic can cause degeneration of body tissues leading to severe impairment their function. Neuroinflammation is defined an response central nervous system involving microglia, astrocytes, cytokines including chemokines. It considered important neurodegerative diseases, Alzheimer's disease, Parkinson's disease amyotrophic lateral sclerosis. Lipopolysaccharide (LPS) strong immunogenic particle present outer membrane Gram-negative bacteria. major triggering factor cascade bacteria infection. The use LPS pro-inflammatory agent well-known model applied both vivo vitro studies. This review offers summary pathogenesis associated with exposure, especially field neuroinflammation. Moreover, we analyzed different models utilized area neuroscience. paper presents recent knowledge focused new insights experimental model.

Язык: Английский

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Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 175, С. 116651 - 116651

Опубликована: Апрель 30, 2024

Voltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest potential therapeutic target across various diseases. In this review, we present comprehensive examination of Kv1.3 channels, highlighting their fundamental characteristics recent advancements utilizing inhibitors for treating autoimmune disorders, neuroinflammation, cancers. Notably, is prominently expressed immune cells implicated responses inflammation associated with diseases chronic inflammatory conditions. Moreover, its aberrant expression certain tumors underscores role cancer progression. While preclinical studies have demonstrated the efficacy inhibitors, clinical translation remains pending. Molecular imaging techniques offer promising avenues tracking assessing efficacy, thereby facilitating development application. Challenges future directions inhibitor research are also discussed, emphasizing significant targeting strategy spectrum

Язык: Английский

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Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer’s disease-related neuropathology

Progress in Neurobiology, Год журнала: 2024, Номер 235, С. 102591 - 102591

Опубликована: Март 13, 2024

Язык: Английский

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Stem Cell Therapy for Alzheimer’s Disease: A Scoping Review for 2017–2022

Biomedicines, Год журнала: 2023, Номер 11(1), С. 120 - 120

Опубликована: Янв. 3, 2023

Alzheimer’s disease (AD) has been a major causal factor for mortality among elders around the world. The treatments AD, however, are still in stage of development. Stem cell therapy, compared to drug therapies and many other therapeutic options, advantages is very promising future. There four types stem cells used AD therapy: neural cells, mesenchymal embryonic induced pluripotent cells. All them have applications treatments, either at (1) cellular level, an (2) animal model, or (3) clinical level. In general, more were studied on level than We suggest future studies increase research various include cross-disciplinary with diseases. future, there could also be improvements timeliness individualization AD.

Язык: Английский

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Regulation of microglia function by neural stem cells

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Март 1, 2023

Neural stem and precursor cells (NPCs) build regenerate the central nervous system (CNS) by maintaining their pool (self-renewal) differentiating into neurons, astrocytes, oligodendrocytes (multipotency) throughout life. This has inspired research pro-regenerative therapies that utilize transplantation of exogenous NPCs or recruitment endogenous adult for CNS regeneration repair. Recent advances in single-cell RNA sequencing other “omics” have revealed express not just traditional progenitor-related genes, but also genes involved immune function. Here, we review how exert immunomodulatory function regulating biology microglia, are present NPC niches CNS. We discuss role transplanted microglia fates, such as survival, proliferation, migration, phagocytosis activation, developing, injured degenerating provide a literature on NPC-specific mediators responsible modulating biology. Our highlights properties significance these findings context designing diseased

Язык: Английский

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Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 976 - 976

Опубликована: Янв. 12, 2024

Over the past 20 years, stem cell therapy has been considered a promising option for treating numerous disorders, in particular, neurodegenerative disorders. Stem cells exert neuroprotective and benefits through different mechanisms, such as secretion of neurotrophic factors, replacement, activation endogenous cells, decreased neuroinflammation. Several sources have proposed transplantation restoration damaged tissue. recent decades, intensive research focused on gestational novel resource therapy. The present review provides an update preclinical/clinical applications treatment protein-misfolding diseases including Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD) amyotrophic lateral sclerosis (ALS). However, further studies should be encouraged to translate this therapeutic approach into clinical setting.

Язык: Английский

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Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Май 17, 2024

Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca 2+ flow through membrane. Among all channels, key regulators of neuronal excitability voltage-gated potassium (K V ), largest family K + channels. Due to ROS high levels in aging brain, might be affected by oxidative agents neurodegeneration processes. This review provides new insight about channelopathies most studied neurodegenerative disorders, such as Alzheimer Disease, Parkinson’s Huntington Disease or Spinocerebellar Ataxia. The main these diseases 1, 2.1, 3, 4 7. Moreover, order prevent repair development diseases, previous channel modulators have been proposed therapeutic targets.

Язык: Английский

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The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2

Applied immunohistochemistry & molecular morphology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

A major goal in Alzheimer disease (AD) research is the reduction of abnormal tau burden. Using multispectral analyses on brain tissues from humans who died AD it was documented that neurons with hyperphosphorylated protein accumulate many proteins BCL2 family, including those block cell turnover (eg, BCL2, MCL1, BCLXL) and promote NOXA, PUMA, BAK, BAX). mouse model humanized used to test hypothesis shifting this balance a pro-cell milieu would reduce burden concomitant clinical improvement. Here, we show death at 11 15 months due CNS tauopathy had marked after treatment FDA-approved drug venetoclax, which blocks BCL2. The number target positive for venetoclax spinal cord 94.5% as determined by immunohistochemistry 98.1% modified Bielchowsky stain. began neurofibrillary tangles (NFTs) were evident there neuroinflammation. treated mice robust until sacrificed 13 compared untreated showed unequivocal evidence damage both clinically autopsy. We conclude otherwise inexorable deposition, even initiation, can be prevented one anti-cell abundant NFTs human AD.

Язык: Английский

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Multifunctional magneto-electric and exosome-loaded hydrogel enhances neuronal differentiation and immunoregulation through remote non-invasive electrical stimulation for neurological recovery after spinal cord injury

Bioactive Materials, Год журнала: 2025, Номер 48, С. 510 - 528

Опубликована: Фев. 28, 2025

Язык: Английский

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Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Abstract The development of the brain involves proliferation neural stem cells (NSCs) and differentiation neurogenic cells, including neurons, astrocytes, oligodendrocytes. growth other in brain, microglia blood vessels, are also crucial for maintaining normal function. In first part, intrinsic regulatory mechanisms NSCs during neurogenesis primarily delved into. This focused on effects epigenetic modifications NSCs. Additionally, phenomenon where their own proliferative behavior leads to activation immune‐related genes discussed. Furthermore, impact maternal immune explored. Finally, reasons underlying differences between humans mice examined. second origin microglia, heterogeneity developmental process, surrounding third relationship cerebrovascular system includes communication interaction vessels NSCs, as well cytokines secreted by synapses genesis glial cells.

Язык: Английский

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