Multiple Sclerosis: A Story of the Interaction Between Gut Microbiome and Components of the Immune System
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
Multiple
sclerosis
(MS)
is
defined
as
an
inflammatory
disorder
that
chronically
affects
the
central
nervous
system
of
young
people
mostly
and
distributed
globally.
It
associated
with
degeneration
demyelination
myelin
sheath
around
nerves,
resulting
in
multiple
neurological
disability
symptoms
ranging
from
mild
to
severe
cases
end
paralysis
sometimes.
MS
one
rising
diseases
globally
unfortunately
reduced
quality
life
adding
national
economic
burdens.
The
definite
mechanism
not
clearly
defined;
however,
all
previous
researches
confirm
role
immune
master
contributor
pathogenesis.
Innate
adaptive
cells
are
activated
peripherally
then
attracted
toward
(CNS)
due
breakdown
blood–brain
barrier.
Recently,
gut-brain
axis
was
shown
depend
on
gut
metabolites
produced
by
different
microorganisms
colon.
difference
microbiota
composition
between
individuals
responsible
for
diversity
secreted
affect
responses
locally
or
systemically
when
reach
blood
circulation
brain.
may
enhance
suppress
(repeated
short
forms);
consequently,
it
exacerbate
ameliorate
symptoms.
Recent
data
showed
some
can
be
used
adjuvant
therapy
other
diseases.
This
review
sheds
light
nature
possible
interaction
regulation
through
axis,
hence
contributing
Язык: Английский
Necrotizing Enterocolitis and Neurodevelopmental Impairments: Microbiome, Gut, and Brain Entanglements
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1254 - 1254
Опубликована: Окт. 4, 2024
There
is
significant
communication
and
interdependence
among
the
gut,
microbiome,
brain
during
development.
Diseases,
such
as
necrotizing
enterocolitis
(NEC),
highlight
how
injury
to
immature
gastrointestinal
tract
leads
long-term
neurological
consequences,
due
vulnerabilities
of
in
early
stages
life.
A
better
understanding
developing
gut–microbiota–brain
axis
needed
both
prevent
treat
devastating
consequences
these
disease
processes.
The
a
bidirectional
pathway
that
includes
metabolic,
nervous,
endocrine,
immune
components.
In
this
review,
we
discuss
gut
development,
microbiome
colonization
maturation,
interactions
influence
neurodevelopment
context
NEC.
We
describe
components
gut–brain
an
integral
member
relationship.
Finally,
explore
derangements
within
affect
normal
development
function
other
systems
neurodevelopmental
for
patients.
Язык: Английский
SIV-specific antibodies protect against inflammasome-driven encephalitis in untreated macaques
Cell Reports,
Год журнала:
2024,
Номер
43(10), С. 114833 - 114833
Опубликована: Окт. 1, 2024
Язык: Английский
Comparative analysis of the B cell receptor repertoire during relapse and remission in patients with multiple sclerosis
Clinical Immunology,
Год журнала:
2024,
Номер
269, С. 110398 - 110398
Опубликована: Ноя. 17, 2024
Язык: Английский
The Emerging Role of Immunoglobulins and Complement in the Stimulation of Neuronal Activity and Repair: Not as Simple as We Thought
Biomolecules,
Год журнала:
2024,
Номер
14(10), С. 1323 - 1323
Опубликована: Окт. 18, 2024
Neurologic
disorders
such
as
traumatic
brain
injury,
multiple
sclerosis,
Alzheimer’s
disease,
and
drug-resistant
epilepsy
have
a
high
socioeconomic
impact
around
the
world.
Current
therapies
for
these
are
often
not
effective.
This
creates
demand
development
of
new
therapeutic
approaches
to
treat
disorders.
Recent
data
suggest
that
autoreactive
naturally
occurring
immunoglobulins
produced
by
subsets
B
cells,
called
B1
combined
with
complement,
actively
involved
in
processes
restoration
neuronal
functions
during
pathological
conditions
remyelination.
The
focus
this
review
is
discuss
possibility
creating
specific
antibodies
can
activate
fix
complement
enhance
survival
promote
central
nervous
system
repair
after
injuries
associated
many
types
neurodegenerative
diseases.
Язык: Английский