Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral hypoperfusion rats DOI Creative Commons
Bin Fan, Ying Zhang, Qihang Luo

и другие.

Brain Research Bulletin, Год журнала: 2024, Номер 208, С. 110897 - 110897

Опубликована: Фев. 8, 2024

A typical enriched environment (EE), which combines physical activity and social interaction, has been proven to mitigate cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, it remains unclear how the different components of EE promote recovery after CCH. This study stripped out into environmental enrichment (PE) (SE), compared neuroprotective effects PE, SE (PSE) in The results novel object recognition Morris water maze tests showed that SE, PSE improved function CCH rats. Additionally, Nissl TUNEL staining revealed three EEs reduced neuronal loss hippocampus. exhibited superior functional improvement PE while there was no significant difference between SE. Furthermore, lipid peroxidation hippocampus with decreasing levels MDA increasing activities SOD GSH. expression SLC7A11 GPX4 increased, level p53 EEs. suggested inhibited ferroptosis maintaining redox homeostasis Three IL-β, TNF-α, IL-6, thereby inhibiting neuroinflammation. Western blotting immunofluorescence indicated also TLR4/MyD88/p38MAPK signaling pathway. These findings collectively demonstrated alleviated hippocampal neuroinflammation rats, reducing loss, might be associated inhibition Moreover, supported is only through combination exercise interaction optimal can achieved. provided valuable insights for prevention treatment vascular impairment.

Язык: Английский

Physical and social environmental enrichment alleviate ferroptosis and inflammation with inhibition of TLR4/MyD88/p38MAPK pathway in chronic cerebral hypoperfusion rats DOI Creative Commons
Bin Fan, Ying Zhang, Qihang Luo

и другие.

Brain Research Bulletin, Год журнала: 2024, Номер 208, С. 110897 - 110897

Опубликована: Фев. 8, 2024

A typical enriched environment (EE), which combines physical activity and social interaction, has been proven to mitigate cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, it remains unclear how the different components of EE promote recovery after CCH. This study stripped out into environmental enrichment (PE) (SE), compared neuroprotective effects PE, SE (PSE) in The results novel object recognition Morris water maze tests showed that SE, PSE improved function CCH rats. Additionally, Nissl TUNEL staining revealed three EEs reduced neuronal loss hippocampus. exhibited superior functional improvement PE while there was no significant difference between SE. Furthermore, lipid peroxidation hippocampus with decreasing levels MDA increasing activities SOD GSH. expression SLC7A11 GPX4 increased, level p53 EEs. suggested inhibited ferroptosis maintaining redox homeostasis Three IL-β, TNF-α, IL-6, thereby inhibiting neuroinflammation. Western blotting immunofluorescence indicated also TLR4/MyD88/p38MAPK signaling pathway. These findings collectively demonstrated alleviated hippocampal neuroinflammation rats, reducing loss, might be associated inhibition Moreover, supported is only through combination exercise interaction optimal can achieved. provided valuable insights for prevention treatment vascular impairment.

Язык: Английский

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