Neuroscience Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Язык: Английский
PLoS Biology, Год журнала: 2024, Номер 22(10), С. e3002884 - e3002884
Опубликована: Окт. 29, 2024
Our understanding of brain circuit operations and disorders has rapidly outpaced our ability to intervene restore them. Developing technologies that can precisely interface with any region may combine diagnostics therapeutic intervention, expediting personalised medicine. Transcranial ultrasound stimulation (TUS) is a promising noninvasive solution this challenge, offering focal precision scalability. By exploiting the biomechanics pressure waves on tissue, TUS enables multi-site targeted neuromodulation across distributed circuits in cortex deeper areas alike. In Essay, we explore emergent evidence functionally test modify dysfunctional regions, effectively serving as search rescue tool for brain. We define challenges opportunities faced by it moves towards greater target integration advanced monitoring interventional technology. Finally, propose roadmap evolution progresses from research clinically validated disorders.
Язык: Английский
Процитировано
5
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
Abstract Background Astrocytes are abundant in the brain and their calcium signaling is reported to have an important effect on neuronal activity both physiological pathological conditions. Low-frequency focused ultrasound (FUS) has recently emerged as a powerful noninvasive neuromodulation approach, yet its impact astrocyte dynamics different states vivo poorly understood. Objective This study aimed elucidate effects of non-thermal FUS dynamic with cellular-resolution cell-type-specific recording identify whether influences cortical astrocytes neurons distinctive state dependent. Methods Here we combined customized 0.521MHz transducer two-photon microscopy, allowing simultaneous single-cell resoultion imaging stimulation at intensities 0.91 or 1.5 W/cm 2 examine responses somatosensory cortex awake lightly anesthetized mice. Functional clustering analysis was performed response activated inhibited subpopulations. Results In mice, significantly enhanced amplitude, frequency, temporal integral transients, while suppressing reducing proportion contrast, mice displayed blunted increased negligible modulation under FUS, suggesting that baseline suppression from anesthesia partially masks effects. Conclusions Our demonstrated elicited distinctive, state-dependent neurons, highlighting previously underappreciated targets neuromodulation. These findings will pave way for FUS-based therapies targeting astrocyte–neuron interactions conditions involving abnormal excitability. Highlights Low duty cycle low frequency induced heat Ultrasound markedly transients suppressed The cell types were reduced light anesthesia.
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Май 14, 2025
Traumatic brain injury is a leading cause of death and major risk factor for the development both memory motor disorders. To date, there are no proven interventions to improve patient outcome after neurotrauma. A promising avenue treatment has emerged in use non-invasive therapies recovery injury. number stimulation techniques have been developed, such as transcranial direct current stimulation, magnetic vagus nerve well low intensity ultrasound photobiomodulation therapy. However, standardized regimens not developed. There clear need better understand underlying mechanisms therapeutics on pathology so more effectively guide strategy. Here we review literature preclinical neurotrauma offer insight into potential mechanism action novel targets traumatic
Язык: Английский
Процитировано
0
Neuroscience Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0