Progress in Neurobiology, Год журнала: 2025, Номер 249, С. 102770 - 102770
Опубликована: Апрель 19, 2025
Язык: Английский
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 19, 2025
Abstract While electrical activity in neurons has been extensively studied, the transport and distribution of adenosine triphosphate (ATP), primary cellular energy carrier, remain less understood, particularly relation to metabolic processes axons. ATP is primarily generated mitochondria consumed at synapses, sites demand. Even healthy axons, approximately half synaptic boutons lack stationary mitochondria, raising questions about between with without mitochondrial production. This study addresses two key questions: role spontaneous neuronal firing maintaining levels during periods low demand ability a single bouton donated mitochondrion supply neighboring lacking mitochondria. Using computational simulations, examines under various patterns distributions, incorporating factors such as quiescent periods, duty cycles, diffusivity. Spontaneous stabilizes demand, preventing reactive oxygen species (ROS) release from Simulations reveal that damaged by neurodegeneration, containing can support multiple empty boutons. However, number increases, concentration declines, potentially falling below critical threshold required for transmission. Nomenclature 0 kinetic constant characterizing rate consumption A c cross-sectional area axon C per unit length typical value min minimum sustain transmission cycle D diffusivity cytosol f frequency which neuron fires active phase i action potentials occur total propagate down plus were missed L distance m production mass tissue N CV t time x position along half-length Greek symbols γ percentage volume occupied δ width an axonal varicosity ϖ individual Λ homeostatic portion expended on maintenance
Язык: Английский
Процитировано
0
Results in Engineering, Год журнала: 2025, Номер unknown, С. 104053 - 104053
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Heat and Mass Transfer, Год журнала: 2025, Номер 242, С. 126790 - 126790
Опубликована: Фев. 16, 2025
Язык: Английский
Процитировано
0
Cells, Год журнала: 2025, Номер 14(7), С. 545 - 545
Опубликована: Апрель 4, 2025
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, impaired urine concentration—lead to intracellular extracellular dehydration, exacerbating decline. We examine molecular mechanisms regulation involving AQPs osmolytes, describe how dehydration contributes structural metabolic dysfunction across key biological compartments, kidney, brain, bone, skeletal muscle. Physiological hallmark intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight impairs solvent capacity, solute transport, protein conformation, communication. Despite known macronutrients geriatric nutrition, hydration remains an often-overlooked factor aging management. argue its inclusion fourth pillar nutritional approach veterinary geriatrics, alongside protein, fat, fiber. By investigating aging-associated dogs—species that share environments lifestyle patterns humans—we propose hydration-centered strategies promote healthy comparative medicine.
Язык: Английский
Процитировано
0
Progress in Neurobiology, Год журнала: 2025, Номер 249, С. 102770 - 102770
Опубликована: Апрель 19, 2025
Язык: Английский
Процитировано
0