The contribution of granger causality analysis to our understanding of cardiovascular homeostasis: from cardiovascular and respiratory interactions to central autonomic network control

Frontiers in Network Physiology, Год журнала: 2024, Номер 4

Опубликована: Авг. 8, 2024

Homeostatic regulation plays a fundamental role in maintenance of multicellular life. At different scales and biological systems, this principle allows better understanding organization. Consequently, growing interest studying cause-effect relations between physiological systems has emerged, such as the fields cardiovascular cardiorespiratory regulations. For this, mathematical approaches Granger causality (GC) were applied to field physiology last 20 years, overcoming limitations previous offering new perspectives cardiac, vascular respiratory homeostatic interactions. In clinical practice, continuous recording data hospitalized patients or by telemetry opened applicability for these with potential early diagnostic prognostic information. review, we describe theoretical background based on linear GC time frequency domains detect couplings series RR intervals, blood pressure respiration. Interestingly, tools help contribution negative feedback anticipatory feedforward mechanisms controls. We also experimental results tools, consolidating evidence coupling studies. Finally, propose allowing complete interactions well interplay brain high integrative view regulation.

Язык: Английский

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Unanticipated evolution of cardio-respiratory interactions with cognitive load during a Go-NoGo shooting task in virtual reality

Computers in Biology and Medicine, Год журнала: 2024, Номер 182, С. 109109 - 109109

Опубликована: Сен. 10, 2024

Язык: Английский

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Information-Theoretic Analysis of Cardio-Respiratory Interactions in Heart Failure Patients: Effects of Arrhythmias and Cardiac Resynchronization Therapy

Entropy, Год журнала: 2023, Номер 25(7), С. 1072 - 1072

Опубликована: Июль 17, 2023

The properties of cardio-respiratory coupling (CRC) are affected by various pathological conditions related to the cardiovascular and/or respiratory systems. In heart failure, one most common cardiac conditions, degree CRC changes primarily depend on type heart-rhythm alterations. this work, we investigated in heart-failure patients, applying measures from information theory, i.e., Granger Causality (GC), Transfer Entropy (TE) and Cross (CE), quantify directed causality between (RR interval) (Resp) time series. Patients were divided into three groups depending their rhythm (sinus presence low/high number ventricular extrasystoles) studied also after resynchronization therapy (CRT), distinguishing responders non-responders therapy. information-theoretic analysis bidirectional interactions HF patients revealed strong effect nonlinear components RR (high Resp series (respiratory sinus arrhythmia) as well causal interactions. We showed that GC a linear model measure is not sensitive both only free TE CE may them. CRT mainly exhibit unchanged asymmetry values, with statistically significant dominance flow over opposite Resp, before CRT. was Our results indicate success corresponding transfer signal quantified at baseline measurements, which could contribute better selection for

Язык: Английский

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Cardiac Autonomic Function and Functional Capacity in Post-COVID-19 Individuals with Systemic Arterial Hypertension

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(9), С. 1391 - 1391

Опубликована: Сен. 18, 2023

Individuals diagnosed with systemic arterial hypertension (SAH) are considered risk groups for COVID-19 severity. This study assessed differences in cardiac autonomic function (CAF) and functional capacity (FC) SAH individuals without infection compared to post-COVID-19. Participants comprised 40 aged 31 80 years old, grouped as (G1; n = 21) (G2; 19). CAF was via heart rate variability (HRV), measuring R-R intervals during a 10-min supine period. Four HRV indices were analyzed through symbolic analysis: 0V%, 1V%, 2LV%, 2UV%. FC assessment performed by 6-min walk test (6MWT). G1 G2 showed no significant terms of age, anthropometric parameters, clinical presentation, medication use. exhibited superior 6MWT performance, covering more distance (522 ± 78 vs. 465 59 m, p < 0.05). Specifically, demonstrated moderate positive correlation between the 2LV% index (r 0.58; Shorter walking distances observed However, did not find impaired post-COVID-19 those without. suggests that while impacted FC, remained relatively stable this population.

Язык: Английский

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Maternal cardiorespiratory coupling: differences between pregnant and nonpregnant women are further amplified by sleep-stage stratification

Journal of Applied Physiology, Год журнала: 2023, Номер 135(5), С. 1199 - 1212

Опубликована: Сен. 28, 2023

We compare CRC, i.e., the reciprocal interaction between cardiac and respiratory systems, healthy pregnant nonpregnant women for first time. Although CRC is present in both groups, reduced during pregnancy; there less synchronization maternal activity a smaller response heart rate to inhalations exhalations. Stratifying this analysis by sleep stages reveals that differences are most prominent deep sleep.

Язык: Английский

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Cardio-Respiratory and Muscle Oxygenation Responses to Submaximal and Maximal Exercise in Normobaric Hypoxia: Comparison between Children and Adults

Biology, Год журнала: 2023, Номер 12(3), С. 457 - 457

Опубликована: Март 16, 2023

As differential physiological responses to hypoxic exercise between adults and children remain poorly understood, we aimed comprehensively characterise cardiorespiratory muscle oxygenation submaximal maximal in normobaric hypoxia the two groups. Following familiarisation, fifteen (Age = 9 ± 1 years) 22 2 completed graded cycling sessions exhaustion a randomized single-blind manner normoxia (NOR; FiO2 20.9) (HYP; 13.0) exercises conditions. Age-specific workload increments were 25 W·3 min-1 for 40 adults. Gas exchange vastus lateralis parameters measured continuously via metabolic cart near-infrared spectroscopy, respectively. Hypoxia provoked significant decreases power output PMAX (children 29%; 16% (F 39.3; p < 0.01)) at gas threshold 10%; adults:18% 8.08; both Comparable changes noted most respiratory similar outputs Children, however, demonstrated, lower PETCO2 throughout test during maintenance of V˙CO2 output. These data indicate that, while acute are comparable adults, there exist age-related select parameters.

Язык: Английский

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Assessment of Cardio-Respiratory Relationship during and after Exercise in Healthy Recreative Male Subjects: A Pilot Study

Applied Sciences, Год журнала: 2024, Номер 14(12), С. 5170 - 5170

Опубликована: Июнь 14, 2024

Background: Understanding the responses of cardio and respiratory systems during exercise, as well their coupling in post-exercise recovery, is important for prescription exercise programs physically recreative subjects. Aim: In this work, we aimed to set up an adjusted experiment evaluate relations changes parameters obtained from analysis cardiac signals under three physiological conditions: relaxation, recovery. Material Methods: Simultaneously recorded ECG (RR intervals) signal bicycle ergometry until submaximal heart rate (HR), recovery 10 healthy men were analyzed. The included consecutive phases 3 min duration with a constant workload. Parasympathetic control (RMSSD), breathing frequency (BF), cycle amplitude (RCA) calculated. Anthropometric data also collected. Results: Based on time series analysis, our results show that: (1) increase HR was related reduction variability RMSSD, while BF RCA, (2) RCA significantly decreased, RMSSD had biphasic response. multiple linear regressions showed that averaged HR, segments determined by several calculated collected parameters. Conclusions: RR interval conditions relaxation along anthropometric data, contributed complexity cardiopulmonary after males.

Язык: Английский

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Future of Sleep Medicine

Sleep Medicine Clinics, Год журнала: 2024, Номер 20(1), С. 149 - 164

Опубликована: Ноя. 26, 2024

Язык: Английский

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Machine Learning Classification of Pediatric Health Status Based on Cardiorespiratory Signals with Causal and Information Domain Features Applied—An Exploratory Study

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(23), С. 7353 - 7353

Опубликована: Дек. 2, 2024

This study aimed to evaluate the accuracy of machine learning (ML) techniques in classifying pediatric individuals-cardiological patients, healthy participants, and athletes-based on cardiorespiratory features from short-term static measurements. It also examined impact coupling (CRC)-related (from causal information domains) modeling identify a preferred feature set that could be further explored for specialized tasks, such as monitoring training progress or diagnosing health conditions.

Язык: Английский

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Predictive Modeling of Heart Rate from Respiratory Signals at Rest in Young Healthy Humans

Entropy, Год журнала: 2024, Номер 26(12), С. 1083 - 1083

Опубликована: Дек. 11, 2024

Biological signals such as respiration (RSP) and heart rate (HR) are oscillatory physiologically coupled, maintaining homeostasis through regulatory mechanisms. This report models the dynamic relationship between RSP HR in 45 healthy volunteers at rest. Cross-correlation was computed, along with regression analysis to predict from its first-order time derivative continuous signals. A simulation model tested possibility of replicating RSP–HR relationship. results showed a lag sub-second range these (849.21 ms ± SD 344.84). The possible modulation by mediated amplitude (in cases). this process allowed us replicate physiological HR. These provide support for understanding interactions cardiorespiratory coupling rest, showing short signal RSP. would optionally be incorporated into resting cardiopulmonary suggests mechanism optimizing alveolar system promoting synchrony gases hemoglobin pulmonary system.

Язык: Английский

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