Musician’s dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments

Frontiers in Network Physiology, Год журнала: 2025, Номер 4

Опубликована: Янв. 22, 2025

This perspective article addresses the critical and up-to-date problem of task-specific musician’s dystonia (MD) from both theoretical practical perspectives. Theoretically, MD is explored as a result impaired sensorimotor interplay across different brain circuits, supported by most frequently cited scientific evidence—each referenced dozens times in Scopus. Practically, significant issue it occurs over 60 more musicians compared to other professions, underscoring influence individual training well environmental, social, emotional factors. To address these challenges, we propose novel application FeeSyCy principle (feedback-synchrony-plasticity), which emphasizes pivotal role feedback guiding inter-neuronal synchronization plasticity—the foundation learning memory. model integrates with established literature form comprehensive framework for understanding an FeeSyCy-mediated relationship between their environment, ultimately leading trauma. The proposed approach provides advantages enabling development innovative therapeutic preventive strategies. Specifically, lays groundwork multimodal psycho-physical therapies aimed at restoring balance neural circuits affected MD. These strategies include personalized psychotherapy combined physical rehabilitation psychological physiological dimensions integration offers value-added solution this pressing problem, potential broad applicability similar conditions.

Язык: Английский

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Entrainment by transcranial alternating current stimulation: Insights from models of cortical oscillations and dynamical systems theory

Physics of Life Reviews, Год журнала: 2025, Номер 53, С. 147 - 176

Опубликована: Март 14, 2025

Язык: Английский

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Information entropy dynamics, self-organization, and cybernetical neuroscience

Frontiers in Network Physiology, Год журнала: 2025, Номер 5

Опубликована: Март 21, 2025

A version of the speed-gradient evolution models for systems obeying maximum information entropy principle developed by H. Haken in his book 1988 is proposed this article. An explicit relation specifying system dynamics general linear constraints established. Two versions human brain detailed balance-breaking model are proposed. In addition, contours a new scientific field called cybernetical neuroscience dedicated to control neural have been outlined.

Язык: Английский

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Rhythmic modulation of subthalamo-pallidal interactions depends on synaptic rewiring through inhibitory plasticity

Physical Review Research, Год журнала: 2025, Номер 7(2)

Опубликована: Май 9, 2025

Aberrant oscillatory activity is a hallmark of several brain disorders including Parkinson's disease (PD). Specifically, interactions between neurons the subthalamic nucleus (STN) and globus pallidus externus (GPe) may contribute to emergence maintenance overly synchronized beta-band (15–30 Hz) oscillations be associated with motor symptoms PD. Excessive beta synchrony can mitigated by pharmacological intervention deep stimulation (DBS). Alternatively, strategies that aim selectively modulate interpopulation connections have therapeutic potential. Here, we tested computationally whether dual targeting STN GPe time-shifted pathologically strong synapses through inhibitory spike-timing-dependent plasticity. More specifically, examined how paired stimuli delivered lead synaptic rewiring. To end, first theoretically analyzed optimal range time shift frequency for effective Then, as minimal model generating in healthy PD conditions, considered STN-GPe loop biologically inspired parameters. Time-shifted modified long-lasting This ultimately caused desynchronizing aftereffects, resulting reduced coupling network restoration dynamics. Our findings demonstrate critical role neuroplasticity shaping effects optimization variety multisite paradigms aimed at reshaping dysfunctional networks Published American Physical Society 2025

Язык: Английский

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Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli

PLoS Computational Biology, Год журнала: 2022, Номер 18(11), С. e1010568 - e1010568

Опубликована: Ноя. 3, 2022

Synaptic dysfunction is associated with several brain disorders, including Alzheimer's disease, Parkinson's disease (PD) and obsessive compulsive disorder (OCD). Utilizing synaptic plasticity, stimulation capable of reshaping connectivity. This may pave the way for novel therapies that specifically counteract pathological For instance, in PD, multichannel coordinated reset (CRS) was designed to neuronal synchrony down-regulate CRS shown entail long-lasting therapeutic aftereffects PD patients related animal models. marked contrast conventional deep (DBS) therapy, where symptoms return shortly after ceases. In present paper, we study by periodic (PMCS) networks leaky integrate-and-fire (LIF) neurons spike-timing-dependent plasticity (STDP). During PMCS, phase-shifted stimulus trains are delivered segregated subpopulations. Harnessing STDP, PMCS leads changes network structure. We found PMCS-induced structure depend on both phase lags between stimuli shape individual stimuli. Single-pulse burst low intraburst frequency synapses receiving simultaneously. contrast, high up-regulate these synapses. derive theoretical approximations stimulation-induced enables us formulate strategies inducing a variety structures. Our results provide testable hypotheses future pre-clinical clinical studies suggest be suitable plastic Furthermore, insight how type affect outcome DBS. strongly impact parameter adjustment procedures DBS, which, so far, primarily focused acute effects stimulation.

Язык: Английский

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Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation

Frontiers in Human Neuroscience, Год журнала: 2023, Номер 16

Опубликована: Янв. 26, 2023

Introduction Parkinson's disease (PD) is a movement disorder characterized by the pathological beta band (15–30 Hz) neural oscillations within basal ganglia (BG). It shown that suppression of abnormal correlated with improvement PD motor symptoms, which goal standard therapies including deep brain stimulation (DBS). To overcome stimulation-induced side effects and inefficiencies conventional DBS (cDBS) to reduce administered current, closed-loop adaptive (aDBS) techniques were developed. In this method, frequency and/or amplitude are modulated based on various biomarkers. Methods Here, computational modeling cortico-BG-thalamic network in normal conditions, we show aDBS subthalamic nucleus (STN) modulation leads more effective parkinsonian BG. Results Our results restored their range reliability response thalamic neurons cortex commands retained due modulation. Furthermore, notably less current during compared cDBS control STN local field potential (LFP) activity. Discussion Efficient models may contribute clinical development optimized designed patients while leading better therapeutic outcome.

Язык: Английский

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Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders

Frontiers in Network Physiology, Год журнала: 2023, Номер 3

Опубликована: Сен. 5, 2023

The brain plays central role in regulating physiological systems, including the skeleto-muscular and locomotor system. Studies of cortico-muscular coordination have primarily focused on associations between movement tasks dynamics specific waves. However, brain-muscle functional networks synchronous among waves muscle activity rhythms that underlie control remain unknown. Here we address following fundamental questions: what are structure networks; whether main network mediators control; how hierarchical organization relates to distinct states under autonomic regulation such as wake, sleep, sleep stages; altered with neurodegenerative disorders. We study interactions all physiologically relevant across cortical locations leg chin healthy Parkinson's disease (PD) subjects. Utilizing Network Physiology framework time delay stability approach, find 1) each state is characterized by a unique profile links strength; 2) particular play during state; 3) PD leads muscle-specific breakdown networks, altering sleep-stage stratification pattern connectivity strength. In subjects exhibit pronounced stronger wake light weaker REM deep sleep. contrast, reorganize decline strength non-REM increase REM, leading markedly different gradual from Further, stages profiles, which PD, indicating disruption communication rhythms. Our findings demonstrate presence previously unrecognized basic principles locomotion, potential clinical implications for novel network-based biomarkers early detection disorders, movement,

Язык: Английский

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Feedback control of collective dynamics in an oscillator population with time-dependent connectivity

Frontiers in Network Physiology, Год журнала: 2024, Номер 4

Опубликована: Фев. 2, 2024

We present a numerical study of pulsatile feedback-based control synchrony level in highly-interconnected oscillatory network. focus on nontrivial case when the system is close to synchronization transition point and exhibits collective rhythm with strong amplitude modulation. pay special attention technical but essential steps like causal real-time extraction signal interest from noisy measurement estimation instantaneous phase amplitude. The feedback loop’s parameters are tuned automatically suppress synchrony. Though motivated by neuroscience, results relevant controlling activity ensembles various natures and, thus, rapidly developing field network physiology.

Язык: Английский

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The onset of motor learning impairments in Parkinson’s disease: a computational investigation

Brain Informatics, Год журнала: 2024, Номер 11(1)

Опубликована: Янв. 29, 2024

The basal ganglia (BG) is part of a basic feedback circuit regulating cortical function, such as voluntary movements control, via their influence on thalamocortical projections. BG disorders, namely Parkinson's disease (PD), characterized by the loss neurons in substantia nigra, involve progressive motor functions. At present, PD incurable. Converging evidences suggest onset PD-specific pathology prior to appearance classical signs. This latent phase neurodegeneration particular relevance developing more effective therapies intervening at earliest stages disease. Therefore, key challenge research identify and validate markers for preclinical prodromal illness. We propose mechanistic neurocomputational model mesoscopic scale investigate behavior simulated neural system after several degrees lesion with aim possibly evaluating which smallest compromising learning. In other words, we developed working framework analysis theoretical early-stage PD. While simulations healthy conditions confirm role dopamine learning, pathological network predicts that there may exist abnormalities learning process, physiological alterations BG, do not yet presence symptoms typical clinical diagnosis.

Язык: Английский

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Coordinated reset stimulation of plastic neural networks with spatially dependent synaptic connections

Frontiers in Network Physiology, Год журнала: 2024, Номер 4

Опубликована: Май 28, 2024

Abnormal neuronal synchrony is associated with several neurological disorders, including Parkinson's disease (PD), essential tremor, dystonia, and epilepsy. Coordinated reset (CR) stimulation was developed computationally to counteract abnormal synchrony. During CR stimulation, phase-shifted stimuli are delivered multiple sites. Computational studies in plastic neural networks reported that drove the into an attractor of a stable desynchronized state by down-regulating synaptic connections, which led long-lasting desynchronization effects outlasted stimulation. Later, corresponding therapeutic were found animal models PD patients. To date, it unclear how spatially dependent as typically observed brain, shape CR-induced downregulation effects.

Язык: Английский

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